Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Rohini Desetty"'
Autor:
David V Rasicci, Prince Tiwari, Skylar ML Bodt, Rohini Desetty, Fredrik R Sadler, Sivaraj Sivaramakrishnan, Roger Craig, Christopher M Yengo
Publikováno v:
eLife, Vol 11 (2022)
The auto-inhibited, super-relaxed (SRX) state of cardiac myosin is thought to be crucial for regulating contraction, relaxation, and energy conservation in the heart. We used single ATP turnover experiments to demonstrate that a dilated cardiomyopath
Externí odkaz:
https://doaj.org/article/2a972567fd55436c8074580ba6a5c3a8
Autor:
David V Rasicci, Prince Tiwari, Skylar ML Bodt, Rohini Desetty, Fredrik R Sadler, Sivaraj Sivaramakrishnan, Roger Craig, Christopher M Yengo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d666a9f4e73b507afa727aa42d6fe91
https://doi.org/10.7554/elife.77415.sa2
https://doi.org/10.7554/elife.77415.sa2
Publikováno v:
Biophys J
Cardiac muscle contraction is driven by the molecular motor myosin, which uses the energy from ATP hydrolysis to generate a power stroke when interacting with actin filaments, although it is unclear how this mechanism is impaired by mutations in myos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::892f06a0a71aae7a1e73927aff41fb39
https://doi.org/10.1016/j.bpj.2021.04.007
https://doi.org/10.1016/j.bpj.2021.04.007
Publikováno v:
Biophysical Journal. 122:259a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3911a8f60d4ff8e99865efad2a5c2bd6
https://doi.org/10.1016/j.bpj.2022.11.1490
https://doi.org/10.1016/j.bpj.2022.11.1490
Publikováno v:
Molecular biology of the cell. 33(1)
Class III myosins are actin-based motors proposed to transport cargo to the distal tips of stereocilia in the inner ear hairs cells and/or to participate in stereocilia length regulation, which is especially important during development. Mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc2cc9091fa716a232b0abfa500076a
https://pubmed.ncbi.nlm.nih.gov/34788109
https://pubmed.ncbi.nlm.nih.gov/34788109
Cardiac muscle contraction is driven by the molecular motor myosin that uses the energy from ATP hydrolysis to generate a power stroke when interacting with actin filaments, while it is unclear how this mechanism is impaired by mutations in myosin th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62d07bfbaba3fb96a474cf8b0a0a28ae
https://doi.org/10.1101/2020.12.08.416511
https://doi.org/10.1101/2020.12.08.416511
Autor:
David V. Rasicci, Prince Tiwari, Rohini Desetty, Fredrik Sadler, Sivaraj Sivaramakrishnan, Roger W. Craig, Christopher M. Yengo
Publikováno v:
Biophysical Journal. 121:260a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44c1cd20906aa3e90f2db29f6d99595
https://doi.org/10.1016/j.bpj.2021.11.1439
https://doi.org/10.1016/j.bpj.2021.11.1439
Publikováno v:
J Biol Chem
We investigated a dilated cardiomyopathy (DCM) mutation (F764L) in human β-cardiac myosin by determining its motor properties in the presence and absence of the heart failure drug omecamtive mecarbil (OM). The mutation is located in the converter do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ce32c1b7c5606532e32640257811f5
https://europepmc.org/articles/PMC6873177/
https://europepmc.org/articles/PMC6873177/
Publikováno v:
Biophysical Journal. 120:344a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfb50028d24a993487f047972810b30
https://doi.org/10.1016/j.bpj.2020.11.2146
https://doi.org/10.1016/j.bpj.2020.11.2146
Publikováno v:
Biophysical Journal. 118:425a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4395f8f83155a4bcce86792388a7accc
https://doi.org/10.1016/j.bpj.2019.11.2391
https://doi.org/10.1016/j.bpj.2019.11.2391