Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Roheeth D. Delima"'
Autor:
John K. Olynyk, Kevin D. Croft, Anita C. G. Chua, Ross M. Graham, Debbie Trinder, Roheeth D. Delima, Janina E.E. Tirnitz-Parker, Eng K. Gan
Publikováno v:
Hepatology. 56:585-593
Mutations in hemochromatosis protein (HFE) or transferrin receptor 2 (TFR2) cause hereditary hemochromatosis (HH) by impeding production of the liver iron-regulatory hormone, hepcidin (HAMP). This study examined the effects of disruption of Hfe or Tf
Autor:
Ross M. Graham, Roheeth D. Delima, John K. Olynyk, Daniel M. Johnstone, Pablo Moscato, Carlos Riveros, Debbie Trinder, Rodney J. Scott, Elizabeth A. Milward
Publikováno v:
Brain Research. 1448:144-152
Severe disruption of brain iron homeostasis can cause fatal neurodegenerative disease, however debate surrounds the neurologic effects of milder, more common iron loading disorders such as hereditary hemochromatosis, which is usually caused by loss-o
Autor:
Ross M. Graham, Roheeth D. Delima, Debbie Trinder, Carly E. Herbison, Gail M. Reutens, Anita C. G. Chua, John K. Olynyk
Publikováno v:
Journal of Hepatology. 48:327-334
Background/Aims: Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport. It is sensitive to high levels of diferric transferrin, which is associated with disorders of iron overload. Also p
Autor:
Brianna Bassett, John K. Olynyk, Bulent Acikyol, Debbie Trinder, Roheeth D. Delima, Daniel M. Johnstone, Ross M. Graham, Evan J. Williams, Elizabeth A. Milward
Publikováno v:
Metal Ions in Neurological Systems ISBN: 9783709110003
Abnormal iron accumulation within the brain is associated with various neurodegenerative diseases; however, there is debate about whether milder disorders of systemic iron loading, such as haemochromatosis, affect the brain. Arguments on both sides o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c37781de57ad5fe4fb33d9289f97038
https://doi.org/10.1007/978-3-7091-1001-0_2
https://doi.org/10.1007/978-3-7091-1001-0_2
Autor:
Debbie Trinder, Daniel M. Johnstone, John K. Olynyk, Elizabeth A. Milward, Rebecca A. O'Leary, Kim W. Carter, Carly E. Herbison, Anita C. G. Chua, Martin J. Firth, Ross M. Graham, Roheeth D. Delima
Publikováno v:
Hepatology (Baltimore, Md.). 52(2)
ron and cholesterol are both essential metabolites in mammalian systems, and too much or too little of either can have serious clinical consequences. In addition, both have been associated with steatosis and its progression, contributing, inter alia,
Autor:
Debbie Trinder, Robert S. Britton, Anita C. G. Chua, Evan H. Morgan, Bruce R. Bacon, John K. Olynyk, Roheeth D. Delima, Robert E. Fleming, Janina E.E. Tirnitz-Parker, Carly E. Herbison, Ross M. Graham
Background & Aims Hereditary haemochromatosis type 3 is caused by mutations in transferrin receptor (TFR) 2. TFR2 has been shown to mediate iron transport in vitro and regulate iron homeostasis. The aim of this study was to determine the role of Tfr2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2e719aab07e941dd690fe055fa649d
https://europepmc.org/articles/PMC2880807/
https://europepmc.org/articles/PMC2880807/
Publikováno v:
Liver international : official journal of the International Association for the Study of the Liver. 27(1)
Autor:
Debbie Trinder, Carly E. Herbison, Robert E. Fleming, Roheeth D. Delima, Peter J. Leedman, John K. Olynyk, Bruce R. Bacon, Sarah F. Drake, Evan H. Morgan, Ross M. Graham, Anita C. G. Chua
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology. 292(1)
Hereditary hemochromatosis type 3 is an iron (Fe)-overload disorder caused by mutations in transferrin receptor 2 (TfR2). TfR2 is expressed highly in the liver and regulates Fe metabolism. The aim of this study was to investigate duodenal Fe absorpti