Impact of CCR5Δ32 on the risk of infection, Staphylococcus aureus carriage, and plasma concentrations of chemokines in Danish blood donors.

Autor: Dinh KM; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. Electronic address: khoadinh@rm.dk., Kaspersen KA; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Aarhus, Denmark., Mikkelsen S; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Kjerulff BD; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Aarhus, Denmark., Boldsen JK; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark; Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Aarhus, Denmark., Petersen MS; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark., Burgdorf KS; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Sørensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Aagaard B; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Forman-Ankjær B; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Banasik K; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hansen TF; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Danish Headache Center, Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark., Nyegaard M; Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark., Rohde PD; Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hjalgrim H; Danish Cancer Society Research Center, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut; Department of Haematology, Copenhagen University Hospital, Rigshospitalet., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Immunology, Zealand University Hospital, Køge, Denmark., Ullum H; Statens Serum Institut, Denmark., Erikstrup LT; Department of Clinical Microbiology, Aarhus University Hospital, Aarhus, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.

Publikováno v: EBioMedicine [EBioMedicine] 2024 Nov; Vol. 109, pp. 105406. Date of Electronic Publication: 2024 Oct 21.

Genome-wide association meta-analysis identifies five loci associated with postpartum hemorrhage.

Autor: Westergaard D; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Methods and Analysis, Statistics Denmark, Copenhagen, Denmark., Steinthorsdottir V; deCODE genetics/Amgen, Reykjavik, Iceland., Stefansdottir L; deCODE genetics/Amgen, Reykjavik, Iceland., Rohde PD; Department of Health Science and Technology, Aalborg University, Gistrup, Denmark., Wu X; Department of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Geller F; Department of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Tyrmi J; Centre for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Havulinna AS; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Finnish Institute for Health and Welfare - THL, Helsinki, Finland., Solé-Navais P; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Flatley C; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Ostrowski SR; Department of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Clinical medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen OB; Department of Clinical medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical immunology, Zealand University Hospital, Køge, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Sørensen E; Department of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, University of Copenhagen, Copenhagen, Denmark., Bruun MT; Clinical Immunological Research Unit, Department of Clinical Immunology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Aagaard Jensen B; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Brodersen T; Department of Clinical immunology, Zealand University Hospital, Køge, Denmark., Ullum H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Magnus P; Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway., Andreassen OA; NORMENT Centre, University of Oslo, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway., Njolstad PR; Mohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.; Children and Youth Clinic, Haukeland University Hospital, Bergen, Norway., Kolte AM; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark., Krebs L; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Department of Clinical medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Nyegaard M; Department of Health Science and Technology, Aalborg University, Gistrup, Denmark., Hansen TF; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Danish Headache Center, Department of neurology, Copenhagen University Hospital, Glostrup, Denmark., Feenstra B; Department of Clinical immunology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Daly M; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lindgren CM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Big Data Institute Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, UK., Thorleifsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Stefansson OA; deCODE genetics/Amgen, Reykjavik, Iceland., Sveinbjornsson G; deCODE genetics/Amgen, Reykjavik, Iceland., Gudbjartsson DF; deCODE genetics/Amgen, Reykjavik, Iceland.; School of Science and Engineering, Reykjavik University, Reykjavik, Iceland., Thorsteinsdottir U; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, Reykjavik University, Reykjavik, Iceland., Banasik K; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jacobsson B; Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.; Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Laivuori H; Centre for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynaecology, Tampere University Hospital, Tampere, Finland., Stefansson K; deCODE genetics/Amgen, Reykjavik, Iceland.; Faculty of Medicine, School of Health Sciences, Reykjavik University, Reykjavik, Iceland., Brunak S; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Soren.brunak@cpr.ku.dk., Nielsen HS; Department of Obstetrics and Gynaecology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark. Henriette.svarre.nielsen@regionh.dk.; Department of Clinical medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Henriette.svarre.nielsen@regionh.dk.

Publikováno v: Nature genetics [Nat Genet] 2024 Aug; Vol. 56 (8), pp. 1597-1603. Date of Electronic Publication: 2024 Jul 22.

Calcium Scoring Improves Clinical Management in Patients With Low Clinical Likelihood of Coronary Artery Disease.

Autor: Brix GS; Department of Cardiology, Gødstrup Hospital, Herning, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rasmussen LD; Department of Cardiology, Gødstrup Hospital, Herning, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Rohde PD; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Schmidt SE; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Nyegaard M; Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Douglas PS; Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA., Newby DE; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK., Williams MC; BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Scotland, UK., Foldyna B; Department of Radiology, Cardiovascular Imaging Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts, USA., Knuuti J; Turku PET Centre, Turku University Hospital, University of Turku, Kiinamyllynkatu, Turku, Finland., Bøttcher M; Department of Cardiology, Gødstrup Hospital, Herning, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark., Winther S; Department of Cardiology, Gødstrup Hospital, Herning, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: sw@dadlnet.dk.

Publikováno v: JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2024 Jun; Vol. 17 (6), pp. 625-639. Date of Electronic Publication: 2024 Jan 03.

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.

Autor: Venkatesh SS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Wittemans LBL; Novo Nordisk Research Centre Oxford, Oxford, United Kingdom.; Nuffield Department of Women's and Reproductive Health, Medical Sciences Division, University of Oxford, United Kingdom., Palmer DS; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Baya NA; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Ferreira T; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom., Hill B; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Lassen FH; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom., Parker MJ; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom., Reibe S; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom., Elhakeem A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Banasik K; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark., Bruun MT; Department of Clinical Immunology, Odense University Hospital, Odense, Denmark., Erikstrup C; Department of Clinical Immunology, Aarhus University Hospital, Aarhus, Denmark.; Department of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark., Jensen BA; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Juul A; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen; Copenhagen, Denmark.; Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark., Mikkelsen C; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Science, Copenhagen University, Copenhagen, Denmark., Nielsen HS; Department of Obstetrics and Gynecology, The Fertility Clinic, Hvidovre University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ostrowski SR; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen OB; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Zealand University Hospital, Kge, Denmark., Rohde PD; Genomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Sorensen E; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Ullum H; Statens Serum Institut, Copenhagen, Denmark., Westergaard D; Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark., Haraldsson A; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Children's Hospital Iceland, Landspitali University Hospital, Reykjavik, Iceland., Holm H; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Jonsdottir I; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Olafsson I; Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland., Steingrimsdottir T; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Obstetrics and Gynecology, Landspitali University Hospital, Reykjavik, Iceland., Steinthorsdottir V; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Figueredo J; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Karjalainen MK; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Research Unit of Population Health, Faculty of Medicine, University of Oulu, Finland.; Northern Finland Birth Cohorts, Arctic Biobank, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu, Oulu, Finland., Pasanen A; Research Unit of Clinical Medicine, Medical Research Center Oulu, University of Oulu, and Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Jacobs BM; Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University London, London, EC1M 6BQ, United Kingdom., Hubers N; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Institute, Amsterdam, The Netherlands., Lippincott M; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Fraser A; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Lawlor DA; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Timpson NJ; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom.; Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom., Nyegaard M; Genomic Medicine, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark., Stefansson K; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; deCODE genetics/Amgen, Inc., Reykjavik, Iceland., Magi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Laivuori H; Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.; Medical and Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynecology, Tampere University Hospital, Finland.; Center for Child, Adolescent, and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Finland., van Heel DA; Blizard Institute, Queen Mary University London, London, E1 2AT, United Kingdom., Boomsma DI; Department of Biological Psychology, Netherlands Twin Register, Vrije Universiteit, Amsterdam, The Netherlands.; Amsterdam Reproduction and Development Institute, Amsterdam, The Netherlands., Balasubramanian R; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Seminara SB; Harvard Reproductive Sciences Center and Reproductive Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America.; Harvard Medical School, Boston, Massachusetts, United States of America., Chan YM; Harvard Medical School, Boston, Massachusetts, United States of America.; Division of Endocrinology, Department of Pediatrics, Boston Children's Hospital, Boston, Massachusetts, United States of America., Laisk T; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lindgren CM; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, United Kingdom.; Nuffield Department of Women's and Reproductive Health, Medical Sciences Division, University of Oxford, United Kingdom.; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, United States of America.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2024 Mar 20. Date of Electronic Publication: 2024 Mar 20.

A Genetic Analysis of Current Medication Use in the UK Biobank.

Autor: Rohde PD; Genomic Medicine, Department of Health Science and Technology, Aalborg University, 9220 Aalborg, Denmark.

Publikováno v: Journal of personalized medicine [J Pers Med] 2024 Mar 20; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 20.