Zobrazeno 1 - 10 of 67 pro vyhledávání: '"Rohan W. Jayasekara"'
1
Changing phenotype, early clinical course and clinical predictors of inflammatory bowel disease in Sri Lanka: a retrospective, tertiary care-based, multi-centre study
Autor: Rohan W. Jayasekara, R. Peiris, A.P. de Silva, S.K. Kodisinghe, A. V. G. A. M. Jayatissa, Madunil A. Niriella, N.M.M. Navarathne, Udaya Kalubovila, I.K. Liyanage, S. R. Kumarasena, H.J. de Silva
Publikováno v: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Gastroenterology
Background Inflammatory bowel disease (IBD) is increasing in the Asia-Pacific region, with changes in disease phenotype and course. We aimed to assess the changing phenotypes of IBD over ten years, describe the early clinical course (ECC) and identif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ccdafd71f5b39ac713e14114da3dab
https://doaj.org/article/4b0355ef593b407c8a7a0269cc26e300
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3
Genetic associations of inflammatory bowel disease in a South Asian population
Autor: Rohan W. Jayasekara, Udaya Kalubovila, R. Peiris, Senerath Kuleesha Kodisinghe, Metthananda Nawarathne, Sujeewa R Kumarasena, S.D. Nanayakkara, I.K. Liyanage, Thilakshi Silva, Dunya Luke, Vajira H. W. Dissanayake, Arjuna Priyadarsin De Silva, Madunil A. Niriella, Hithanadura Janaka de Silva, Nimna Rajapakshe
Publikováno v: World Journal of Clinical Cases
AIM To estimate prevalence and phenotypic associations of selected inflammatory bowel disease (IBD)-associated genetic variants among Sri Lankan patients. METHODS A case study of histologically confirmed ulcerative colitis (UC) or Crohn's disease (CD
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662a81010f6590c489a1a8c9d9e3efcd
http://europepmc.org/articles/PMC6288502
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4
Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia - a preliminary report
Autor: K. P. Sem, G. R. Constantine, Rohan W. Jayasekara, Roshni R. Singaraja, C. S. Paththinige, J. R. D. K. Rajapakse, Vajira H. W. Dissanayake
Publikováno v: Lipids in Health and Disease
Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-7 (2018)
Background Hypercholesterolemia is a major determinant of cardiovascular disease-associated morbidity and mortality. Mutations in the LDL-receptor (LDLR) gene are implicated in the majority of the cases with familial hypercholesterolemia (FH). Howeve
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27986a02feecb06fc24208ebdef21e1
https://pubmed.ncbi.nlm.nih.gov/29720182
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5
Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women
Autor: Gustaaf A. Dekker, Claire T. Roberts, Vajira H. W. Dissanayake, Prabha H. Andraweera, Rohan W. Jayasekara
Publikováno v: The Journal of Maternal-Fetal & Neonatal Medicine. 29:1072-1076
Elevated pro-inflammatory cytokines play an important role in the pathogenesis of preeclampsia. We investigated the prevalence of functional polymorphisms in genes regulating inflammation in preeclamptic women.One hundred seventy-five nulliparous Sin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c599d333dab84a20d63bfac9572e28ee
https://doi.org/10.3109/14767058.2015.1034102
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6
Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia
Autor: Hemantha Senanayake, Vajira H. W. Dissanayake, Rohan W. Jayasekara, Ranmalee Amarasekara
Publikováno v: Journal of Obstetrics and Gynaecology Research. 41:662-669
Aim This study was aimed at detecting, identifying, quantifying and comparing the bacteria present in the placental tissues of women with pre-eclampsia with that of normotensive pregnant women. Material and Methods Placental tissue samples were colle
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b414525b2d625cc481c27d3933c3c3ae
https://doi.org/10.1111/jog.12619
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7
Polymorphisms in the fibrinolytic pathway genes and the risk of recurrent spontaneous abortion
Autor: Claire T. Roberts, S. D. Thompson, Gustaaf A. Dekker, R. C. Nowak, Prabha H. Andraweera, Rohan W. Jayasekara, Vajira H. W. Dissanayake
Publikováno v: Reproductive BioMedicine Online. 29:745-751
Impaired fibrinolytic activity is implicated in the pathogenesis of recurrent spontaneous abortion (RSA). This case-control study assessed the prevalence of polymorphisms in fibrinolytic system genes in RSA. Cases comprised 202 Sinhalese women who ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59c42e46bdf05d97e8646b1240287e37
https://doi.org/10.1016/j.rbmo.2014.08.014
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8
Extra and Intramuscular Distribution of the Thoracodorsal Nerve with Regard to Nerve Reconstruction Surgeries
Autor: A.P. Malalasekera, Thushan Beneragama, Sivasuganthan Kanesu, Rohan W. Jayasekara, Vithoosan Sahathevan
Publikováno v: Journal of Reconstructive Microsurgery. 32:358-360
Background The lateral branch of the thoracodorsal nerve (LBTN) is used for nerve transfer in facial, musculocutaneous, axillary nerve injuries and for irreparable C5, C6 spinal nerve lesions and accessory nerve defects. For a successful surgical out
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd16b6f721f8add8587708176d12c1e
https://doi.org/10.1055/s-0036-1579541
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9
Cytogenetic analysis of chromosomal abnormalities in Sri Lankan children
Autor: Sharmila Thillainathan, Nirmala D. Sirisena, Vajira H. W. Dissanayake, Kariyawasam Warnakulathanthrige Jayani C. Kariyawasam, Rohan W. Jayasekara
Publikováno v: World Journal of Pediatrics. 11:374-379
Cytogenetic analysis is a valuable investigation in the diagnostic work up of children with suspected chromosomal disorders. The objective of this study was to describe the prevalence of various types of chromosomal abnormalities in Sri Lankan childr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69864e311cf58b5a2335bca2238e9b5
https://doi.org/10.1007/s12519-014-0526-5
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10
A Child with a Novel de novo Mutation in the Aristaless Domain of the Aristaless-Related Homeobox (ARX) Gene Presenting with Ambiguous Genitalia and Psychomotor Delay
Autor: Rohan W. Jayasekara, Nirmala D. Sirisena, Ken McElreavey, K. Shamya H. de Silva, Anu Bashamboo, Vajira H. W. Dissanayake
Publikováno v: Sexual Development. 8:156-159
The objective of this study was to identify disease-causing mutations in a Sri Lankan male child presenting with ambiguous genitalia and psychomotor delay using the exome sequencing approach. A novel mutation in the aristaless-related homeobox (ARX)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b65ccc2d3f6129b39eb867342f95577
https://doi.org/10.1159/000365458
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