Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Rohan Varshney"'
Autor:
Paula O. Cooper, Sarah S. Kleb, Satish K. Noonepalle, Veronica M. Amuso, Rohan Varshney, Michael C. Rudolph, Tanvir K. Dhaliwal, Darlene V. Nguyen, Miguel F. Mazumder, Najuma S. Babirye, Ruchi Gupta, Bao-Ngoc Nguyen, Brett A. Shook
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114288- (2024)
Summary: Lipids have emerged as potent regulators of immune cell function. In the skin, adipocyte lipolysis increases the local pool of free fatty acids and is essential for coordinating early macrophage inflammation following injury. Here, we invest
Externí odkaz:
https://doaj.org/article/1fe22ae4fe064e07b1147b35c748ad01
Autor:
Phoebe Ohene-Marfo, Hoang Van M. Nguyen, Sabira Mohammed, Nidheesh Thadathil, Albert Tran, Evan H. Nicklas, Dawei Wang, Ramasamy Selvarani, Jacob W. Farriester, Rohan Varshney, Michael Kinter, Arlan Richardson, Michael C. Rudolph, Sathyaseelan S. Deepa
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2813 (2024)
Chronic inflammation is a key player in metabolic dysfunction-associated fatty liver disease (MAFLD) progression. Necroptosis, an inflammatory cell death pathway, is elevated in MAFLD patients and mouse models, yet its role is unclear due to the dive
Externí odkaz:
https://doaj.org/article/19bcd7770fc44cf5bda3791ce36308f9
Autor:
Rohan Varshney, Snehasis Das, G. Devon Trahan, Jacob W. Farriester, Gregory P. Mullen, Gertrude Kyere-Davies, David M. Presby, Julie A. Houck, Patricia G. Webb, Monika Dzieciatkowska, Kenneth L. Jones, Matthew S. Rodeheffer, Jacob E. Friedman, Paul S. MacLean, Michael C. Rudolph
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105750- (2023)
Summary: Establishing metabolic programming begins during fetal and postnatal development, and early-life lipid exposures play a critical role during neonatal adipogenesis. We define how neonatal consumption of a low omega-6 to −3 fatty acid ratio
Externí odkaz:
https://doaj.org/article/9bad93f7d4e444bcbb9d60d4a40fb54f
Autor:
Bridget E. Young, Gertrude Kyere-Davies, Jacob W. Farriester, Rohan Varshney, Paul S. MacLean, Nancy F. Krebs, Michael C. Rudolph
Publikováno v:
Nutrients, Vol 14, Iss 20, p 4238 (2022)
The prevalence of childhood obesity has increased nearly ten times over the last 40 years, influenced by early life nutrients that have persistent effects on life-long metabolism. During the first six months, infants undergo accelerated adipose accum
Externí odkaz:
https://doaj.org/article/2441807dbd064296b11459b21a81b003
Autor:
Shahrouz Ghafoory, Rohan Varshney, Tyler Robison, Karim Kouzbari, Sean Woolington, Brennah Murphy, Lijun Xia, Jasimuddin Ahamed
Publikováno v:
Blood Advances, Vol 2, Iss 5, Pp 470-480 (2018)
Abstract: Transforming growth factor-β1 (TGF-β1) signaling in hepatic stellate cells (HSCs) plays a primary role in liver fibrosis, but the source of TGF-β1 is unclear. Because platelets are rich in TGF-β1, we examined the role of platelet TGF-β
Externí odkaz:
https://doaj.org/article/68a3dbe40ba34752b8c44b57d0b18889
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2039 (2021)
Free radicals, or reactive oxygen species, have been implicated as one of the primary causes of myocardial pathologies elicited by chronic diseases and age. The imbalance between pro-oxidants and antioxidants, termed “oxidative stress”, involves
Externí odkaz:
https://doaj.org/article/2e36732bc189469998f0f13eb245fc50
Autor:
Jeffrey Laurence, Sonia Elhadad, Tyler Robison, Hunter Terry, Rohan Varshney, Sean Woolington, Shahrouz Ghafoory, Mary E Choi, Jasimuddin Ahamed
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187185 (2017)
Human immunodeficiency virus (HIV) infection is an independent risk factor for cardiovascular disease. This risk is magnified by certain antiretrovirals, particularly the protease inhibitor ritonavir, but the pathophysiology of this connection is unk
Externí odkaz:
https://doaj.org/article/edcfb2cc55c147729f325dad14ea24b9
Autor:
Yen-Chun Ho, Xin Geng, Anna O’Donnell, Jaime Ibarrola, Amaya Fernandez-Celis, Rohan Varshney, Kumar Subramani, Zheila J Azartash-Namin, Jang Kim, Robert Silasi, Jill Wylie-Sears, Zahra Alvandi, Lijuan Chen, Boksik Cha, Hong Chen, Lijun Xia, Bin Zhou, Florea Lupu, Harold M. Burkhart, Elena Aikawa, Lorin E. Olson, Jasimuddin Ahamed, Natalia López-Andrés, Joyce Bischoff, Katherine E. Yutzey, R. Sathish Srinivasan
BackgroundCardiac valve disease (CVD) is observed in 2.5% of the general population and 10% of the elderly people. Effective pharmacological treatments are currently not available, and patients with severe CVD require surgery. PROX1 and FOXC2 are tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d000032a201a79dafca023fa1d5d56fc
https://doi.org/10.1101/2023.05.10.540284
https://doi.org/10.1101/2023.05.10.540284
Autor:
Saubhagya Sooradas, Amisha Vatsa, Annanya Negi, Harman Singh, Aditya Mantri, Sanchit Khedkar, Rohan Varshney
Publikováno v:
Community Mental Health and Well-Being in the New Normal ISBN: 9781668472217
Over recent times, multitudinous internal health apps (MHapps) have been developed and made available to smartphone druggies. The pandemic, of course, has put employees under a kind of mental strain few have likely experienced before, so it's no wond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69c071552c05e48e3af261beb5ffbf90
https://doi.org/10.4018/978-1-6684-7221-7.ch009
https://doi.org/10.4018/978-1-6684-7221-7.ch009
Hypothalamic melanocortin-4 receptors on astrocytes mediate inflammation and body weight homeostasis
Autor:
Nicole L. Eliason, Kevin Pham, Rohan Varshney, Jacob W. Farriester, Charles I. Lacy, Heather C. Rice, Michael C. Rudolph, Willard Freeman, Amanda L. Sharpe
World-wide, nearly 40% of the adult population is classified as clinically obese. Central inflammation is highly correlated with obesity and increases morbidity and deterioration of health. The hypothalamus is a brain region that governs many facets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02e6b3bdfca69d78a9364caf8268b400
https://doi.org/10.1101/2022.12.01.518727
https://doi.org/10.1101/2022.12.01.518727