Exploring molecular dynamics simulation to predict binding with ocular mucin: An in silico approach for screening mucoadhesive materials for ocular retentive delivery systems

Autor: Rohan V. Pai, Jasmin Monpara, Pradeep R. Vavia

Publikováno v: Journal of Controlled Release. 309:190-202

In recent times, molecular dynamic (MD) simulations have been applied in the area of drug delivery, as an in silico tool to predict the behaviour of nanoparticles with respect to their interaction with larger biological entities like bilayer membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b0bab26a1afd8b8b36fae6c962c7f94
https://doi.org/10.1016/j.jconrel.2019.07.037

Contributors

Autor: Vinit V. Agnihotri, Mukta Agrawal, Amit Alexander, Purnima D. Amin, Gajanan Arbade, Yogeshwar Bachhav, Shiv Bahadur, Priyanka Bangar, Vikas Bansal, Shreya Basavraj, Veena S. Belgamwar, Vidyadevi T. Bhoyar, Swapnil Borse, Vivek Borse, Shital Butani, Drashti Desai, Prashant K. Deshmukh, Namdev Dhas, Chander Parkash Dora, Gasper Fernandes, S.J.S. Flora, Neha Garg, Atul Garkal, Divya Gopalan, Ashish P. Gorle, Kartik Hariharan, Swapnil N. Jain, Durgesh K. Jha, Pratap Kalyankar, Sameer S. Katiyar, Shubham Khot, Dignesh Khunt, Aditya Narayan Konwar, Ritu Kudarha, Abhijeet Kulkarni, Sanjay Kulkarni, Ashish Kumar, Umesh D. Laddha, Yamini Madav, Hitendra S. Mahajan, Kamlesh D. Mali, Tejal Mehta, Manju Misra, Kailas K. Moravkar, Sadhana Mutalik, Srinivas Mutalik, Ajinkya Nikam, Bharat Padya, Rohan V. Pai, Rohit Pande, Abhijeet Pandey, Chandrakantsing V. Pardeshi, Kamla Pathak, Mrunal Patil, Payal H. Patil, Pravin O. Patil, Sanjay B. Patil, Vandana Patravale, Bala Prabhakar, Mahendra K. Prajapati, Sreeranjini Pulakkat, Amarjitsing Rajput, Hitesh Raotole, Jignasa Savjani, Devanshi S. Shah, Sadhana R. Shahi, Babeeta Shamjetshabam, Shilpa Sharma, Pravin Shende, Ganesh B. Shevalkar, Mahesh Shinde, Rahul Shukla, Ashutosh Singh, Gaurav Sonawane, Raju O. Sonawane, Eliana B. Souto, Sanjay J. Surana, Amol A. Tagalpallewar, Nikunj Tandel, Avinash R. Tekade, Sagar Trivedi, Prashant Upadhaya, Sarika Wairkar, Dattatray Yadav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::575fc7b45fd47d40c1590a4166fb8609
https://doi.org/10.1016/b978-0-12-822522-6.09990-2

Tuning ligand number to enhance selectivity of paclitaxel liposomes towards ovarian cancer

Autor: Mahendra Kumar Prajapati, Rohan V. Pai, Pradeep R. Vavia

Publikováno v: Journal of Drug Delivery Science and Technology. 66:102809

Although several anticancer drugs are currently available to tackle the growing menace of cancer, their efficacy is severely hampered due to their non-selectivity and associated toxicity to the healthy cells. The prime hurdles in the fabrication of e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a4b9772449f92eeca535d1d5ae01c5b
https://doi.org/10.1016/j.jddst.2021.102809

Chitosan oligosaccharide enhances binding of nanostructured lipid carriers to ocular mucins: Effect on ocular disposition

Autor: Pradeep R. Vavia, Rohan V. Pai

Publikováno v: International journal of pharmaceutics. 577

The objective of the study was to assess the effect of enhanced mucoadhesion of a cationic mucoadhesive nanostructured lipid carrier (NLC) on its ocular disposition after topical administration. The NLC was made mucoadhesive by surface coating with c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d42180e33d50101a27e0742844e8d3
https://pubmed.ncbi.nlm.nih.gov/32004680

Development and Evaluation of Chitosan Microparticles Based Dry Powder Inhalation Formulations of Rifampicin and Rifabutin

Autor: Rohan V. Pai, Rajesh R Jain, Anilkumar S. Bannalikar, Mala D Menon

Publikováno v: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 29:179-195

The lung is the primary entry site and target for Mycobacterium tuberculosis; more than 80% of the cases reported worldwide are of pulmonary tuberculosis. Hence, direct delivery of anti-tubercular drugs to the lung would be beneficial in reducing bot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c7aeb71f014d8ac959d2c7f91b8163
https://doi.org/10.1089/jamp.2014.1187