Zobrazeno 1 - 10
of 1 068
pro vyhledávání: '"Rohan T"'
Autor:
Zengjie Xia, Emily E. Prescott, Agnieszka Urbanek, Hollie E. Wareing, Marianne C. King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A. Barnes, Martyna M. Matuszyk, Eleni Dimou, Eric Hidari, Yu P. Zhang, Jeff Y. L. Lam, John S. H. Danial, Michael R. Strickland, Hong Jiang, Peter Thornton, Damian C. Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M. Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B. Wharton, David M. Holtzman, Tarja Malm, Rohan T. Ranasinghe, David Klenerman, Suman De
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Which isoforms of apolipoprotein E (apoE) we inherit determine our risk of developing late-onset Alzheimer’s Disease (AD), but the mechanism underlying this link is poorly understood. In particular, the relevance of direct interactions bet
Externí odkaz:
https://doaj.org/article/65a320a335c64d1798e94a4de6e507f4
Publikováno v:
Journal of Indian Academy of Oral Medicine and Radiology, Vol 35, Iss 4, Pp 497-500 (2023)
Background: Oral cancer is a major public health burden in India, accounting for one-fourth of the global burden and being the most common cancer among males. Objectives: We intend to analyze oral cavity cancer data retrieved from the Report of Hospi
Externí odkaz:
https://doaj.org/article/81ab9010a4e742b98802180804597295
Autor:
Derya Emin, Yu P. Zhang, Evgeniia Lobanova, Alyssa Miller, Xuecong Li, Zengjie Xia, Helen Dakin, Dimitrios I. Sideris, Jeff Y. L. Lam, Rohan T. Ranasinghe, Antonina Kouli, Yanyan Zhao, Suman De, Tuomas P. J. Knowles, Michele Vendruscolo, Francesco S. Ruggeri, Franklin I. Aigbirhio, Caroline H. Williams-Gray, David Klenerman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
α-synuclein aggregates cause neuronal damage, but their heterogeneity complicates studying their toxic properties. Here, the authors analyze α-synuclein aggregates in vitro and study post-mortem brain samples, providing evidence that small aggregat
Externí odkaz:
https://doaj.org/article/d1bb31ace1f144e9b3e898b5d3b5c3e6
Autor:
Eleni Dimou, Taxiarchis Katsinelos, Georg Meisl, Benjamin J. Tuck, Sophie Keeling, Annabel E. Smith, Eric Hidari, Jeff Y.L. Lam, Melanie Burke, Sofia Lövestam, Rohan T. Ranasinghe, William A. McEwan, David Klenerman
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112725- (2023)
Summary: Tau is a soluble protein interacting with tubulin to stabilize microtubules. However, under pathological conditions, it becomes hyperphosphorylated and aggregates, a process that can be induced by treating cells with exogenously added tau fi
Externí odkaz:
https://doaj.org/article/0d8cb954a0e54cd6965759734192cc83
Autor:
Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these
Externí odkaz:
https://doaj.org/article/fb50d58e8455415e95e500de6612683f
Autor:
Rishab Parthasarathy, Rohan T. Bhowmik
Publikováno v:
IEEE Access, Vol 9, Pp 103337-103346 (2021)
Large machine learning models based on Convolutional Neural Networks (CNNs) with rapidly increasing numbers of parameters are being deployed in a wide array of computer vision tasks. However, the insatiable demand for computing resources required to
Externí odkaz:
https://doaj.org/article/7be65e4ab58c411ba985bb0702814b20
Autor:
Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeabi
Externí odkaz:
https://doaj.org/article/66a1b1816bc747869ab5c60b308732ab
Autor:
Erin L. Symonds, Susanne K. Pedersen, David H. Murray, Maher Jedi, Susan E. Byrne, Philippa Rabbitt, Rohan T. Baker, Dawn Bastin, Graeme P. Young
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Cell-free circulating tumour-derived DNA (ctDNA) can be detected by testing for methylated BCAT1 and IKZF1 DNA, which has proven sensitivity for colorectal cancer (CRC). A prospective correlative biomarker study between presence o
Externí odkaz:
https://doaj.org/article/820de594748743c1a3a69ce965684d3f
Autor:
Rohan T. Ranasinghe, Martin R. Challand, Kristina A. Ganzinger, Benjamin W. Lewis, Charlotte Softley, Wolfgang H. Schmied, Mathew H. Horrocks, Nadia Shivji, Jason W. Chin, James Spencer, David Klenerman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Methylated RNA bases influence many life processes, but current detection methods lack the ability to detect individual methylations in single cells. Here, the authors use fluorescence hybridization probes sensitive to methylation to detect specific
Externí odkaz:
https://doaj.org/article/681a36aec6e7448383e2cd2cf34e6586
Autor:
Marie N. Bongiovanni, Julien Godet, Mathew H. Horrocks, Laura Tosatto, Alexander R. Carr, David C. Wirthensohn, Rohan T. Ranasinghe, Ji-Eun Lee, Aleks Ponjavic, Joelle V. Fritz, Christopher M. Dobson, David Klenerman, Steven F. Lee
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Many super-resolution imaging techniques use fluorescence emission intensity to obtain precise positional information, but other spectral information is ignored. Here, the authors develop a method that records the spectrum and position of single dye
Externí odkaz:
https://doaj.org/article/abb20732e92142cb98457e9515465e87