Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rohan N Shah"'
Publikováno v:
eLife, Vol 10 (2021)
MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival
Externí odkaz:
https://doaj.org/article/e5b40cfc226c4f88af0da6f8ae7c2097
Autor:
Rohan N Shah, Alexander J Ruthenburg
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 4, p e1008926 (2021)
Next-generation sequencing (NGS) has transformed molecular biology and contributed to many seminal insights into genomic regulation and function. Apart from whole-genome sequencing, an NGS workflow involves alignment of the sequencing reads to the ge
Externí odkaz:
https://doaj.org/article/18b352bcedc94f33b62bcc9cc323f2b2
Autor:
Rohan N. Shah, Alexander J. Ruthenburg
In 2018, we used internally calibrated chromatin immunoprecipitation (ICeChIP) to find that many of the most commonly used antibodies against H3K4 methylforms had significant off-target binding, which compromised the findings of at least eight litera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef0300f1d9e5d3a3eb7ed1c97d8070e4
https://doi.org/10.1101/2023.01.16.524067
https://doi.org/10.1101/2023.01.16.524067
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
MLL-rearranged leukemia depends on H3K79 methylation. Depletion of this transcriptionally-activating mark by DOT1L deletion or high concentrations of the inhibitor pinometostat downregulates HOXA9 and MEIS1, and consequently reduces leukemia survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57c89d05fd8ab7e9097ce79de8a2643
https://elifesciences.org/articles/64960
https://elifesciences.org/articles/64960
Autor:
Christopher J Lehmann, Rohan N Shah, Mengqi Zhu, Natasha N Pettit, Jessica Ridgway, Renslow Sherer
Publikováno v:
Open Forum Infectious Diseases
Background Coinfection with COVID-19 and a secondary pathogen contributes to morbidity and mortality. Despite its contribution to outcomes, diagnosing coinfection is challenging and no predictive tools have been established. To better assess risk fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d324e4901c06f0bdbb3ee46c00340056
https://doi.org/10.1093/ofid/ofab466.1518
https://doi.org/10.1093/ofid/ofab466.1518
Autor:
Alexander J. Ruthenburg, Beat Fierz, Zhonglei Chen, Shohei Koide, Adrian T. Grzybowski, Takamitsu Hattori, Peter W. Lewis, Jimmy Elias, Rohan N. Shah, Carolin C. Lechner
Publikováno v:
BioRxiv
bioRxiv
bioRxiv
Nucleosomes, composed of DNA and histone proteins, represent the fundamental repeating unit of the eukaryotic genome1; posttranslational modifications of these histone proteins influence the activity of the associated genomic regions to regulate cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7db9cf77c5ec4c61f355a95386c76984
Autor:
Matthew A. Sullivan, Rohan N. Shah, Ivan P. Moskowitz, Alexander J. Ruthenburg, Michael S. Werner, Rangarajan D. Nadadur, Vasiliy Galat, Adrian T. Grzybowski
Publikováno v:
Nature structural & molecular biology
We recently described a new class of long noncoding RNAs (lncRNAs) that are distinguished by especially tight chromatin association and whose presence is strongly correlated to expression of nearby genes. Here, we examine the cis-enhancer mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57962da4ab37faace33f2b8bd4feb30b
https://doi.org/10.1038/nsmb.3424
https://doi.org/10.1038/nsmb.3424
Chromatin immunoprecipitation coupled to next generation sequencing (ChIP-seq) has served as the central method for the study of histone modifications for the last decade. In ChIP-seq, antibodies are used to selectively capture nucleosomes bearing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56fc876f4445a4ee578a3c3284c9eaf3
https://europepmc.org/articles/PMC7158589/
https://europepmc.org/articles/PMC7158589/
Autor:
Alexander J. Ruthenburg, Brandon A. Boone, Rohan N. Shah, Neha Arora, Martis W. Cowles, Zu-Wen Sun, Robert M. Vaughan, Danielle Maryanski, Andrea L. Johnstone, Rochelle L. Tiedemann, Michael-Christopher Keogh, Adrian T. Grzybowski, Marcus A. Cheek, Bradley M. Dickson, Scott B. Rothbart, Matthew J. Meiners, Evan M. Cornett
Publikováno v:
Molecular cell. 72(1)
Histone post-translational modifications (PTMs) are important genomic regulators often studied by chromatin immunoprecipitation (ChIP), whereby their locations and relative abundance are inferred by antibody capture of nucleosomes and associated DNA.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9014f1b4355b6b2e104f9c9568986753
https://pubmed.ncbi.nlm.nih.gov/30244833
https://pubmed.ncbi.nlm.nih.gov/30244833