Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Rohan Gnanaolivu"'
Autor:
Rohan Gnanaolivu, Steven N. Hart
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3472-3480 (2024)
Background: The loss-of-function (LOF) classification of most missense variants in tumor suppressor breast cancer genes BRCA1, BRCA2, PALB2, and RAD51C remains unclassified and confounds clinical actionability. Classifying these variants is challengi
Externí odkaz:
https://doaj.org/article/6d439b45d0c14e08a4063611c86ab5d8
Autor:
Tina Pesaran, Jeffrey N. Weitzel, Clarice R. Weinberg, Chi Gao, Susan L. Neuhausen, Eric C. Polley, Alpa V. Patel, Christopher A. Haiman, Christine B. Ambrosone, Celine M. Vachon, Hongyan Huang, Sara Lindstrom, Julie R. Palmer, Esther M. John, Jill S. Dolinsky, Leslie Bernstein, Rohan Gnanaolivu, Allison W. Kurian, Steven N. Hart, Holly LaDuca, Hoda Anton-Culver, Janet E. Olson, Chunling Hu, Amal Yussuf, Song Yao, Nicole L. Larson, Peter Kraft, Jie Na, Fergus J. Couch, Nicholas J. Boddicker, Elena Martinez, Amy Trentham-Dietz, Siddhartha Yadav, Paul W. Auer, Dale R Sandler, Elizabeth C. Chao, Susan M. Domchek, Rachid Karam, Katherine L. Nathanson, James V. Lacey, Jack A. Taylor, David E. Goldgar
Publikováno v:
J Clin Oncol
PURPOSE To determine the contribution of germline pathogenic variants (PVs) in hereditary cancer testing panel genes to invasive lobular carcinoma (ILC) of the breast. MATERIALS AND METHODS The study included 2,999 women with ILC from a population-ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8def8aabee35accc7948d56b10bbd627
https://doi.org/10.1200/jco.21.00640
https://doi.org/10.1200/jco.21.00640
Autor:
Lauren R. Teras, Siddhartha Yadav, Amy Trentham-Dietz, Dale P. Sandler, James M. Hodge, Elena Ma Martínez, Fergus J. Couch, Jack A. Taylor, Katie M. O'Brien, Alpa V. Patel, Christopher A. Haiman, Chunling Hu, Mia M. Gaudet, David E. Goldgar, Paul W. Auer, James V. Lacey, Nicholas J. Boddicker, Sara Lindström, Celine M. Vachon, Susan L. Neuhausen, Irene M. Ong, Kimberly A. Bertrand, Leslie Bernstein, Loic Le Marchand, Eric C. Polley, Janet E. Olson, Hongyan Huang, Christine B. Ambrosone, Tina Pesaran, Susan M. Domchek, Amal Yussuf, Nicole L. Larson, Rohan Gnanaolivu, Brian D. Carter, Song Yao, Steven N. Hart, Holly LaDuca, Rachid Karam, Jie Na, Chi Gao, Katherine L. Nathanson, Peter Kraft, Elizabeth C. Chao, Huiyan Ma, Jeffrey N. Weitzel, Julie R. Palmer, Christopher E. Scott, Charles Kooperberg, Jill S. Dolinsky, David J. Hunter, Elizabeth S. Burnside
Publikováno v:
J Clin Oncol
PURPOSE The prevalence of germline pathogenic variants (PVs) in established breast cancer predisposition genes in women in the general population over age 65 years is not well-defined. However, testing guidelines suggest that women diagnosed with bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d7a408ed8f3d948b507e21deeaf7dd
https://doi.org/10.1200/jco.21.00531
https://doi.org/10.1200/jco.21.00531
Autor:
Amy Trentham-Dietz, Katie M. O'Brien, Alpa V. Patel, Rohan Gnanaolivu, Chi Gao, Katherine L. Nathanson, Lauren R. Teras, Clarice R. Weinberg, Nicholas J. Boddicker, David J. Hunter, Julie R. Palmer, Polly A. Newcomb, Jeffrey N. Weitzel, Eric J. Jacobs, Dale P. Sandler, Jenna Lilyquist, Leslie Bernstein, Rulla M. Tamimi, Christine B. Ambrosone, Fergus J. Couch, Celine M. Vachon, Esther M. John, Christopher A. Haiman, Jack A. Taylor, Hongyan Huang, Mia M. Gaudet, David E. Goldgar, Irene M. Ong, Susan M. Domchek, Chunling Hu, Sara Lindström, Jie Na, Elizabeth S. Burnside, Susan L. Neuhausen, Janet E. Olson, Eric C. Polley, Song Yao, Peter Kraft, Huiyan Ma, Steven N. Hart, A. Heather Eliassen, Paul L. Auer
Publikováno v:
J Clin Oncol
PURPOSE This study assessed the joint association of pathogenic variants (PVs) in breast cancer (BC) predisposition genes and polygenic risk scores (PRS) with BC in the general population. METHODS A total of 26,798 non-Hispanic white BC cases and 26,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e893f537d3f68fbd24682552486ef7fe
https://doi.org/10.1200/jco.20.01992
https://doi.org/10.1200/jco.20.01992
Autor:
Kelly Fulk, David E. Goldgar, Steven N. Hart, Tina Pesaran, Marcy E. Richardson, Chunling Hu, Kun Y. Lee, Fergus J. Couch, Elizabeth C. Chao, Ashley Deckman, Alvaro N.A. Monteiro, Kate Durda, Rohan Gnanaolivu, Eric C. Polley, Holly LaDuca
Publikováno v:
American Journal of Human Genetics
Summary Determination of the clinical relevance of rare germline variants of uncertain significance (VUSs) in the BRCA2 cancer predisposition gene remains a challenge as a result of limited availability of data for use in classification models. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3741ce40310a372ba413ed0e1a66b4d
https://doi.org/10.1016/j.ajhg.2021.02.005
https://doi.org/10.1016/j.ajhg.2021.02.005
Autor:
Janet E. Olson, Elizabeth S. Burnside, Chi Gao, Heather Eliassen, Paul L. Auer, Chunling Hu, Argyrios Ziogas, Brian D. Carter, James M. Hodge, Lynn Rosenberg, Jack A. Taylor, Rohan Gnanaolivu, Amy Trentham-Dietz, Mia M. Gaudet, Katherine L. Nathanson, David E. Goldgar, Irene M. Ong, Susan M. Gapstur, Katie M. O'Brien, Alpa V. Patel, Charles Kooperberg, Rulla M. Tamimi, David J. Hunter, Christine B. Ambrosone, Celine M. Vachon, Nicholas J. Boddicker, Hoda Anton-Culver, Esther M. John, Song Yao, Jeffrey N. Weitzel, Dale P. Sandler, Christopher G. Scott, Susan L. Neuhausen, Eric C. Polley, Josh Klebba, Jenna Lilyquist, Polly A. Newcomb, Kimberly A. Bertrand, Raed Samara, Kun Y. Lee, Susan M. Domchek, Steven N. Hart, Elisa V. Bandera, Huiyan Ma, Leslie Bernstein, Sara Lindstroem, Sonya Reid, Christopher A. Haiman, Loic Le Marchand, Hongyan Huang, Tuya Pal, Peter Kraft, Eric J. Jacobs, Siddhartha Yadav, Julie R. Palmer, Allison W. Kurian, Fergus J. Couch, Tricia Lindstrom, Clarice R. Weinberg, Jie Na
Publikováno v:
N Engl J Med
The New England journal of medicine, vol 384, iss 5
The New England journal of medicine, vol 384, iss 5
BACKGROUND: Population-based estimates of the risk of breast cancer associated with germline pathogenic variants in cancer-predisposition genes are critically needed for risk assessment and management in women with inherited pathogenic variants. METH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ba8a66045da2d118174a61e6f89e29
https://doi.org/10.1056/nejmoa2005936
https://doi.org/10.1056/nejmoa2005936
Autor:
Thanh P. Ho, Eric C. Polley, Robert R. McWilliams, William R. Bamlet, Steven N. Hart, Kari G. Rabe, Nicholas J. Boddicker, Pashtoon Murtaza Kasi, Fergus J. Couch, Chunling Hu, Siddhartha Yadav, Kun Y. Lee, Gloria M. Petersen, Tricia Lindstrom, Rohan Gnanaolivu
Publikováno v:
Clin Cancer Res
Purpose:To compare the clinical characteristics and overall survival (OS) of germline mutation carriers in homologous recombination repair (HRR) genes and noncarriers with pancreatic ductal adenocarcinoma (PDAC).Experimental Design:Germline DNA from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2410bab69ad8c9c00347e305a29bc95
https://doi.org/10.1158/1078-0432.ccr-20-1788
https://doi.org/10.1158/1078-0432.ccr-20-1788
Autor:
Loic LeMarchand, Esther M. John, Song Yao, Mia M. Gaudet, Chi Gao, Tuya Pal, Julie R. Palmer, Kimberly A. Bertrand, Payal D. Shah, Rohan Gnanaolivu, Katherine L. Nathanson, Chunling Hu, Susan M. Domchek, Peter Kraft, Jie Na, Leslie Bernstein, Fergus J. Couch, David E Goldgar, Eric C. Polley, Elisa V. Bandera, Dale P. Sandler, Christine B. Ambrosone, Jeffrey N. Weitzel, Amy Trentham-Dietz, Siddhartha Yadav, Steven N. Hart, William Yang, Kun Y. Lee, Christopher A. Haiman, Traci N. Bethea, Hongyan Huang, Hoda Anton-Culver
Publikováno v:
JNCI: Journal of the National Cancer Institute. 112:1213-1221
Background The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cea0616e2b160899bd3beaa48d6def5
https://doi.org/10.1093/jnci/djaa040
https://doi.org/10.1093/jnci/djaa040
Autor:
Prema P. Peethambaram, Patrick D. Fitz-Gibbon, Siddhartha Yadav, Daniela L. Stan, Sandhya Pruthi, Nicole P. Sandhu, Nicholas J. Boddicker, Sebastian M. Armasu, Judy C. Boughey, Karthik Ghosh, Janet E. Olson, Eric C. Polley, Christine L. Klassen, Kathryn J. Ruddy, Tufia C. Haddad, Deborah J. Rhodes, Rohan Gnanaolivu, Lonzetta Neal, Kun Y. Lee, Steven N. Hart, Matthew P. Goetz, Susan M. Domchek, Chunling Hu, Tanya L. Hoskin, Jie Na, Fergus J. Couch, Tricia Lindstrom
Publikováno v:
Journal of Clinical Oncology
PURPOSE To determine the sensitivity and specificity of genetic testing criteria for the detection of germline pathogenic variants in women with breast cancer. MATERIALS AND METHODS Women with breast cancer enrolled in a breast cancer registry at a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8faec2b0a6c83e8ce226384a50661b
http://europepmc.org/articles/PMC7193748
http://europepmc.org/articles/PMC7193748
Autor:
Nipun A. Mistry, Shawn McClelland, Rohan Gnanaolivu, Emily Blake, Neiladri Saha, Noemi Vidal-Folch, Feng Li, Chen Wang, Devin Oglesbee, Zhiyv Niu
Publikováno v:
Molecular Genetics and Metabolism. 132:S250-S252
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8013e0fc51fd43d9caf9a0a558af0483
https://doi.org/10.1016/s1096-7192(21)00467-4
https://doi.org/10.1016/s1096-7192(21)00467-4