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Exploring the synergistic behaviour of paclitaxel and vorinostat upon co-loading in albumin nanoparticles for breast cancer management

Autor: Ashwin Abhang, Oly Katari, Rohan Ghadi, Dasharath Chaudhari, Sanyog Jain

Breast cancer is challenging to treat accompanied with poor clinical outcomes. Paclitaxel (PTX) is a first-line chemotherapeutic agent, but possesses limitations due to side effects, high dose, non-specific tissue distribution, and drug resistance. A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9f5632142a0789084bf12995b0e86e4
https://doi.org/10.21203/rs.3.rs-2928600/v1

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Exploring paclitaxel-loaded adenosine-conjugated PEGylated PLGA nanoparticles for targeting triple-negative breast cancer

Autor: Dasharath Chaudhari, Kaushik Kuche, Vivek Yadav, Rohan Ghadi, Tushar Date, Nallamothu Bhargavi, Sanyog Jain

Publikováno v: Drug delivery and translational research.

In present investigation, we developed paclitaxel (PTX)-loaded adenosine (ADN)-conjugated PLGA nanoparticles for combating triple-negative breast cancer (TNBC), where ADN acts as a substrate for adenosine receptors (AR) that are overexpressed in TNBC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad9002ef2ca6a05519c846f9ee378f6e
https://pubmed.ncbi.nlm.nih.gov/36528709

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Self-nanoemulsifying formulation for oral delivery of sildenafil: effect on physicochemical attributes and in vivo pharmacokinetics

Autor: Sanyog Jain, Narinder Kumar, Reena Sharma, Rohan Ghadi, Tushar Date, Nallamothu Bhargavi, Dasharath Chaudhari, Sameer S. Katiyar

Publikováno v: Drug delivery and translational research.

Sildenafil (SLD) is employed for the management of erectile dysfunction and pulmonary arterial hypertension. It exhibits meagre water solubility and is available in the form of citrate salt hydrate to improve the solubility. However, it still exhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e076d2f81e2ecedda57f67ae849431
https://pubmed.ncbi.nlm.nih.gov/36223029

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Lipid- and TPGS-Based Core–Shell-Type Nanocapsules Endowed with High Paclitaxel Loading and Enhanced Anticancer Potential

Autor: Sameer S. Katiyar, Ravindra Patil, Rohan Ghadi, Kaushik Kuche, Varun Kushwah, Chander Parkash Dora, Sanyog Jain

Publikováno v: AAPS PharmSciTech. 23

The current study elucidates the improved drug loading of paclitaxel (PTX) in lipid- and D-α-tocopheryl polyethylene glycol succinate (TPGS)-based core-shell-type lipid nanocapsules (PTX-TPGS-LNC) for augmenting the therapeutic efficacy and curbing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35e269fd83c155c093c3da5c4ecc7406
https://doi.org/10.1208/s12249-022-02389-4

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Unfolding the Potency of Adenosine in Targeting Triple Negative Breast Cancer via Paclitaxel-Incorporated pH-Responsive Stealth Liposomes

Autor: Dasharath Chaudhari, Oly Katari, Rohan Ghadi, Kaushik Kuche, Tushar Date, Nallamothu Bhargavi, Sanyog Jain

Publikováno v: ACS biomaterials scienceengineering. 8(8)

Triple-negative breast cancer (TNBC) belongs to the category of the most destructive forms of breast cancer. Being a highly potent chemotherapeutic agent, paclitaxel (PTX) is extensively utilized in the management of various cancers. Commercially ava

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097affca506b95bfe4a4c57565cc2938
https://pubmed.ncbi.nlm.nih.gov/35896042

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Hitting Multiple Cellular Targets in Triple-Negative Breast Cancer Using Dual-Action Cisplatin(IV) Prodrugs for Safer Synergistic Chemotherapy

Autor: Tushar Date, Kaushik Kuche, Dasharath Chaudhari, Rohan Ghadi, Deepak Kumar Sahel, Deepak Chitkara, Sanyog Jain

Publikováno v: ACS biomaterials scienceengineering. 8(6)

Triple-negative breast cancer (TNBC) cells show improved sensitivity for cisplatin therapy due to their defective DNA damage repair system. However, the clinical utilization of cisplatin is limited by dose-dependent systemic toxicities and chemoresis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b0fa99ec6f3cfd4defac9f0a1f1e1c3
https://pubmed.ncbi.nlm.nih.gov/35522530

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Understanding the Role of Axial Ligands in Modulating the Biopharmaceutical Outcomes of Cisplatin(IV) Derivatives

Autor: Tushar Date, Kaushik Kuche, Rohan Ghadi, Pradeep Kumar, Sanyog Jain

Publikováno v: Molecular pharmaceutics. 19(5)

Cisplatin is a platinum (Pt)-based anticancer drug with broad-scale clinical utility. However, due to its hydrophilic nature and high kinetic reactivity, it offers numerous drug delivery challenges. Limitations such as severe systemic toxicities, che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb0cf4f2076e654b751818ac7d99aa3
https://pubmed.ncbi.nlm.nih.gov/35437994

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