Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rohan Dandage"'
Autor:
Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David Bradley, François J. M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C. Després, Gerald D. Gish, N. T. Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R. Landry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specific
Externí odkaz:
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
Autor:
Johan Hallin, Angel F. Cisneros, Mathieu Hénault, Anna Fijarczyk, Rohan Dandage, Carla Bautista, Christian R. Landry
Publikováno v:
Evolutionary Applications, Vol 13, Iss 6, Pp 1335-1350 (2020)
Abstract Much of the research in biology aims to understand the origin of diversity. Naturally, ecological diversity was the first object of study, but we now have the necessary tools to probe diversity at molecular scales. The inherent differences i
Externí odkaz:
https://doaj.org/article/15c86c6b6a824d1a83f00c3b14febec0
Autor:
Kanika Verma, Kanika Saxena, Rajashekar Donaka, Aseem Chaphalkar, Manish Kumar Rai, Anurag Shukla, Zainab Zaidi, Rohan Dandage, Dhanasekaran Shanmugam, Kausik Chakraborty
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Changes in osmotic homeostasis alter metabolites and therefore chemical milieu of the cells. Here, the authors show that altering metabolites in E. coli also change the cellular capacity for buffering mutations that impair protein folding and influen
Externí odkaz:
https://doaj.org/article/798249b34fd54ac1bcfc784baef16d78
Autor:
Rohan Dandage, Christian R Landry
Publikováno v:
Molecular Systems Biology, Vol 15, Iss 9, Pp 1-18 (2019)
Abstract The protective redundancy of paralogous genes partly relies on the fact that they carry their functions independently. However, a significant fraction of paralogous proteins may form functionally dependent pairs, for instance, through hetero
Externí odkaz:
https://doaj.org/article/2fd31434361845d0905bd839b7ccd8c1
Publikováno v:
PLoS Genetics, Vol 14, Iss 5, p e1007419 (2018)
Organisms maintain competitive fitness in the face of environmental challenges through molecular evolution. However, it remains largely unknown how different biophysical factors constrain molecular evolution in a given environment. Here, using deep m
Externí odkaz:
https://doaj.org/article/a166389ff8e34ee189cc556c00705fd6
Autor:
Rohan Dandage, Nicolas Doucet, Myriam Létourneau, François J.M. Chartier, Gerald D. Gish, Nicolas Bisson, Jean-Philippe Lambert, Ugo Dionne, N. T. Hang Pham, Alexandre K. Dubé, Christian R. Landry, Soham Dibyachintan, Émilie Bourgault, David Bradley, Philippe C Després
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Protein–protein interactions (PPIs) between modular binding domains and their target peptide motifs are thought to largely depend on the intrinsic binding specificities of the domains. The large family of SRC Homology 3 (SH3) domains contribute to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c091dc5126a3fb3f23bb36095a0065a
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
Autor:
Alexandre K, Dubé, Rohan, Dandage, Soham, Dibyachintan, Ugo, Dionne, Philippe C, Després, Christian R, Landry
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2477
Deep mutational scanning (DMS) generates mutants of a protein of interest in a comprehensive manner. CRISPR-Cas9 technology enables large-scale genome editing with high efficiency. Using both DMS and CRISPR-Cas9 therefore allows us to investigate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdabf63bd5a82f4577579eee92d4a8fe
https://pubmed.ncbi.nlm.nih.gov/35524121
https://pubmed.ncbi.nlm.nih.gov/35524121
Autor:
Alexandre K. Dubé, Rohan Dandage, Soham Dibyachintan, Ugo Dionne, Philippe C. Després, Christian R. Landry
Publikováno v:
Methods in Molecular Biology ISBN: 9781071622568
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47e175814dfd961ce5a060be800d6456
https://doi.org/10.1007/978-1-0716-2257-5_14
https://doi.org/10.1007/978-1-0716-2257-5_14
Autor:
Rohan Dandage, Christian R. Landry
Publikováno v:
Cell systems. 12(12)
Cancer treatment strategies include exploiting genetic vulnerabilities offered by synthetic lethal (SL) interactions between paralogs. In this issue of Cell Systems, De Kegel et al. (2021) apply a machine learning approach to predict robust SL paralo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dd2c2c6dfbcd0d5e4eb8933ad246dbf
https://pubmed.ncbi.nlm.nih.gov/34529928
https://pubmed.ncbi.nlm.nih.gov/34529928
Publikováno v:
Cancer Research. 82:6390-6390
Triple-negative breast cancer (TNBC) is a subtype of breast cancer which lacks the expression of key biomarkers, namely Estrogen and Progesterone receptors and HER2. Therefore, it lacks targeted therapies, resulting in the worst prognosis compared to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f6100582150f4983d6cedf678c7d9ea
https://doi.org/10.1158/1538-7445.am2022-6390
https://doi.org/10.1158/1538-7445.am2022-6390