Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Rohan Chippalkatti"'
Autor:
Rohan Chippalkatti, Bianca Parisi, Farah Kouzi, Christina Laurini, Nesrine Ben Fredj, Daniel Kwaku Abankwa
Publikováno v:
European Journal of Cell Biology, Vol 103, Iss 2, Pp 151425- (2024)
The RAS-MAPK-pathway is aberrantly regulated in cancer and developmental diseases called RASopathies. While typically the impact of Ras on the proliferation of various cancer cell lines is assessed, it is poorly established how Ras affects cellular d
Externí odkaz:
https://doaj.org/article/1450c331bc2c419c91c59ee4730bc14e
Publikováno v:
STAR Protocols, Vol 4, Iss 4, Pp 102637- (2023)
Summary: The C2C12 cell line represents a simple in vitro model for cell differentiation. Here, we present a flow-cytometry-based pipeline to quantitate C2C12 cell differentiation based on myosin heavy-chain marker expression. We describe steps for c
Externí odkaz:
https://doaj.org/article/876cd3eb14f24d24b3ac611ecb5be266
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1008913 (2020)
Mitotic divisions depend on the timely assembly and proper orientation of the mitotic spindle. Malfunctioning of these processes can considerably delay mitosis, thereby compromising tissue growth and homeostasis, and leading to chromosomal instabilit
Externí odkaz:
https://doaj.org/article/be61fbae61cf42b7b8f89c0691c5ad60
Autor:
Yashar Rouzbahani, Rohan Chippalkatti, Daniel Abankwa, Anindita Dasgupta, Pablo Carravilla, Christian Eggeling
Publikováno v:
Single Molecule Spectroscopy and Superresolution Imaging XVI.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14fa634cfc2aa02f62d630adfb8de45a
https://doi.org/10.1117/12.2666385
https://doi.org/10.1117/12.2666385
Autor:
Pelin Kaya, Rohan Chippalkatti, Elisabeth Schaffner-Reckinger, Bianca Parisi, Ganesh B. Manoharan, Yashar Rouzbahani, Christian Eggeling, Daniel Abankwa
Publikováno v:
Cancer Research. 83:3493-3493
Most RAS drug targeting strategies focus on KRAS, due to the high KRAS mutation frequency in cancer and its high expression level. Moreover, KRAS4B (hereafter KRAS) but not HRAS is a potent driver of stemness traits in cancer cells. Exactly how KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::062fa414954939f5d289d04da561a1f8
https://doi.org/10.1158/1538-7445.am2023-3493
https://doi.org/10.1158/1538-7445.am2023-3493
Autor:
Rohan Chippalkatti, Daniel Abankwa
Publikováno v:
Biochemical Society Transactions
Cancer stem cells (CSC) may be the most relevant and elusive cancer cell population, as they have the exquisite ability to seed new tumors. It is plausible, that highly mutated cancer genes, such as KRAS, are functionally associated with processes co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9da7cab4eca8432a755c7198383d47a
http://europepmc.org/articles/PMC7925005
http://europepmc.org/articles/PMC7925005
Publikováno v:
Advances in cancer research. 153
Disruption of the native membrane organization of Ras by the farnesyltransferase inhibitor tipifarnib in the late 1990s constituted the first indirect approach to drug target Ras. Since then, our understanding of how dynamically Ras shuttles between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c549a56bfbb26ebd399a9d3a7e72f451
https://pubmed.ncbi.nlm.nih.gov/35101236
https://pubmed.ncbi.nlm.nih.gov/35101236
Publikováno v:
Advances in Cancer Research ISBN: 9780128244852
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d986920fb126fdd7d102dcdbaf421f5
https://doi.org/10.1016/bs.acr.2021.07.005
https://doi.org/10.1016/bs.acr.2021.07.005
Autor:
Rohan Chippalkatti, Beat Suter
Publikováno v:
Journal of Visualized Experiments.
In vivo cell cycle progression analysis is routinely performed in studies on genes regulating mitosis and DNA replication. 5-Ethynyl-2'-deoxyuridine (EdU) has been utilized to investigate replicative/S-phase progression, whereas antibodies against ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826b1648b008a789931e37d7889afe11
https://doi.org/10.3791/62642-v
https://doi.org/10.3791/62642-v
Publikováno v:
PLoS Genetics
Chippalkatti, Rohan; Egger, Boris; Suter, Beat (2020). Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells. PLoS genetics, 16(11), e1008913. Public Library of Science 10.1371/journal.pgen.1008913
PLoS Genetics, Vol 16, Iss 11, p e1008913 (2020)
Chippalkatti, Rohan; Egger, Boris; Suter, Beat (2020). Mms19 promotes spindle microtubule assembly in Drosophila neural stem cells. PLoS genetics, 16(11), e1008913. Public Library of Science 10.1371/journal.pgen.1008913
PLoS Genetics, Vol 16, Iss 11, p e1008913 (2020)
Mitotic divisions depend on the timely assembly and proper orientation of the mitotic spindle. Malfunctioning of these processes can considerably delay mitosis, thereby compromising tissue growth and homeostasis, and leading to chromosomal instabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142a28457374e64339e68e8d2c8657d6
http://europepmc.org/articles/PMC7714366
http://europepmc.org/articles/PMC7714366