Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rohan Balakrishnan"'
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 12, Pp 1-13 (2021)
Abstract To respond to fluctuating conditions, microbes typically need to synthesize novel proteins. As this synthesis relies on sufficient biosynthetic precursors, microbes must devise effective response strategies to manage depleting precursors. To
Externí odkaz:
https://doaj.org/article/309003d5d30c42b09e3b712abf202acf
Autor:
Xiongfeng Dai, Manlu Zhu, Mya Warren, Rohan Balakrishnan, Hiroyuki Okano, James R. Williamson, Kurt Fredrick, Terence Hwa
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT In nature, bacteria frequently experience many adverse conditions, including heat, oxidation, acidity, and hyperosmolarity, which all tend to slow down if not outright stop cell growth. Previous work on bacterial stress mainly focused on und
Externí odkaz:
https://doaj.org/article/6ded3cae351240e9885173243923a252
Autor:
Chenhao Wu, Rohan Balakrishnan, Nathan Braniff, Matteo Mori, Gabriel Manzanarez, Zhongge Zhang, Terence Hwa
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 20
Many cellular activities in bacteria are organized according to their growth rate. The notion that ppGpp measures the cell’s growth rate is well accepted in the field of bacterial physiology. However, despite decades of interrogation and the identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c257b3cee6c2a3547a05ec70af479cdd
https://escholarship.org/uc/item/5js407s8
https://escholarship.org/uc/item/5js407s8
Autor:
Rohan Balakrishnan, Terence Hwa, Matteo Mori, Igor Segota, Zhongge Zhang, Christina Ludwig, Ruedi Aebersold
Publikováno v:
Science
Science (New York, N.Y.), vol 378, iss 6624
Science (New York, N.Y.), vol 378, iss 6624
Bacteria allocate their proteome to cellular functions differently in different growth conditions. It is largely unknown how such allocation arises from known mechanisms of gene regulation while constrained by limited translation capacity and fixed p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::875ec425bed04dfd43fb54a5ebca62e6
https://doi.org/10.1101/2021.05.24.445329
https://doi.org/10.1101/2021.05.24.445329
To sustain growth in fluctuating environments microbial organisms must respond appropriately. The response generally requires the synthesis of novel proteins, but this synthesis can be impeded due to the depletion of biosynthetic precursors when grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cbd94e6c63c01b21693949cbabdb690
https://doi.org/10.1101/2021.04.28.441780
https://doi.org/10.1101/2021.04.28.441780
Autor:
Kurt Fredrick, Michelle R. Gibbs, Rohan Balakrishnan, Leonard J. Foster, Menglin Chen, Kyung-Mee Moon
Publikováno v:
Proceedings of the National Academy of Sciences. 114:980-985
The physiological role of LepA, a paralog of EF-G found in all bacteria, has been a mystery for decades. Here, we show that LepA functions in ribosome biogenesis. In cells lacking LepA, immature 30S particles accumulate. Four proteins are specificall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2122667046e600370c5da831e6ac8281
https://doi.org/10.1073/pnas.1613665114
https://doi.org/10.1073/pnas.1613665114
Autor:
Terence Hwa, Rohan Balakrishnan, Vadim Patsalo, Xiongfeng Dai, Yi-Ping Wang, Kurt Fredrick, Manlu Zhu, James R. Williamson, Mya Warren, Hiroyuki Okano
Publikováno v:
Nature microbiology, vol 2, iss 2
Bacteria growing under different conditions experience a broad range of demand on the rate of protein synthesis, which profoundly affects cellular resource allocation. During fast growth, protein synthesis has long been known to be modulated by adjus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa5a01136d7ff988537078714740400
https://europepmc.org/articles/PMC5346290/
https://europepmc.org/articles/PMC5346290/
Autor:
Ian M.C. Fleming, Kurt Fredrick, Juan D. Alfonzo, Kirk W. Gaston, Rohan Balakrishnan, Mary Anne T. Rubio, Zdeněk Paris
Publikováno v:
Scientific Reports
Most eukaryotic ribosomes contain 26/28S, 5S, and 5.8S large subunit ribosomal RNAs (LSU rRNAs) in addition to the 18S rRNA of the small subunit (SSU rRNA). However, in kinetoplastids, a group of organisms that include medically important members of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fa533bb0605754db2b05ef14e37836
Publikováno v:
Nucleic Acids Research
LepA is a paralog of EF-G found in all bacteria. Deletion of lepA confers no obvious growth defect in Escherichia coli, and the physiological role of LepA remains unknown. Here, we identify nine strains (ΔdksA, ΔmolR1, ΔrsgA, ΔtatB, ΔtonB, Δtol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608d2c8ad41013778e059c2ba3491b3e
https://pubmed.ncbi.nlm.nih.gov/25378333
https://pubmed.ncbi.nlm.nih.gov/25378333