Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Rohan A. Davis"'
Autor:
Cyril T. Namba-Nzanguim, Conrad V. Simoben, Boris D. Bekono, Ian Tietjen, Joel Cassel, Joseph M. Salvino, Luis J. Montaner, Rohan A. Davis, Fidele Ntie-Kang
Publikováno v:
The Microbe, Vol 3, Iss , Pp 100059- (2024)
In silico binding studies were conducted on the known plant-derived polyphenolic tetrameric stilbenoids, (–)-hopeaphenol (1), vaticanol B (2) and vatalbinoside A (3) and their monomeric derivative resveratrol (8), identified from several plant spec
Externí odkaz:
https://doaj.org/article/afc2075cc7264f5a8d0c9e22bd2b420d
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 298 (2024)
Tuberculosis remains a significant global health pandemic. There is an urgent need for new anti-tubercular agents to combat the rising incidence of drug resistance and to offer effective and additive therapeutic options. High-throughput screening of
Externí odkaz:
https://doaj.org/article/90debecfbc8e405cb567616a62ee7621
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 19, Iss 1, Pp 107-114 (2023)
Nine new fluorinated analogues were synthesised by late-stage functionalisation using Diversinate™ chemistry on the Open Source Malaria (OSM) triazolopyrazine scaffold (Series 4). The structures of all analogues were fully characterised by NMR, UV
Externí odkaz:
https://doaj.org/article/47b1a25598904fc99698afc06978edcb
Autor:
Kelsey S. Ramage, Aaron Lock, Jonathan M. White, Merrick G. Ekins, Milton J. Kiefel, Vicky M. Avery, Rohan A. Davis
Publikováno v:
Marine Drugs, Vol 22, Iss 1, p 33 (2024)
The known oxygenated polyhalogenated diphenyl ether, 2-(2′,4′-dibromophenoxy)-3,5-dibromophenol (1), with previously reported activity in multiple cytotoxicity assays was isolated from the sponge Lamellodysidea sp. and proved to be an amenable sc
Externí odkaz:
https://doaj.org/article/b542577dbc8c4ff787036ada173fd849
Autor:
Simon H. Apte, Penny L. Groves, Maxine E. Tan, Viviana P. Lutzky, Tharushi de Silva, Joshua N. Monteith, Stephanie T. Yerkovich, Brendan J. O’Sullivan, Rohan A. Davis, Daniel C. Chambers
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15104 (2023)
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of the interstitial pneumonias. The cause of the disease is unknown, and new therapies that stop or reverse disease progression are desperately needed. Recent advances in next-gen
Externí odkaz:
https://doaj.org/article/8b834532435c46d18febcfd3fdd43bca
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10204 (2023)
Pseudomonas aeruginosa forms stable biofilms, providing a major barrier for multiple classes of antibiotics and severely impairing treatment of infected patients. The biofilm matrix of this Gram-negative bacterium is primarily composed of three major
Externí odkaz:
https://doaj.org/article/661a3ee55f2c457797d77485ec06ba6e
Autor:
Qingqing Wang, Delong Chen, Yining Wang, Chenlin Dong, Jian Liu, Kai Chen, Fangming Song, Chao Wang, Jinbo Yuan, Rohan A. Davis, Vincent Kuek, Haiming Jin, Jiake Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 154, Iss , Pp 113622- (2022)
Osteoclasts play an important role in maintaining the relative stability of bone mass. Abnormal number and function of osteoclasts are closely related to osteoporosis and osteolytic diseases. Thiaplakortone B (TPB), a natural compound derived from th
Externí odkaz:
https://doaj.org/article/227ad4820b88454781063235227d0673
Publikováno v:
Marine Drugs, Vol 21, Iss 5, p 317 (2023)
The incorporation of bromine, iodine or fluorine into the tricyclic core structure of thiaplakortone A (1), a potent antimalarial marine natural product, is reported. Although yields were low, it was possible to synthesise a small nine-membered libra
Externí odkaz:
https://doaj.org/article/462bd368d90f4f7bb0725e71c68cfabb
Autor:
Alanah Varricchio, Sidra Khan, Zoe K. Price, Rohan A. Davis, Sunita A. Ramesh, Andrea J. Yool
Publikováno v:
Cancers, Vol 15, Iss 4, p 1027 (2023)
Impairing the motility of glioblastoma multiforme (GBM) cells is a compelling goal for new approaches to manage this highly invasive and rapidly lethal human brain cancer. Work here characterized an array of pharmacological inhibitors of membrane ion
Externí odkaz:
https://doaj.org/article/eb1cc3a77d4645ba8d604b830d4b93ce
Autor:
H.M.P. Dilrukshi Herath, Sarah Preston, Abdul Jabbar, Jose Garcia-Bustos, Russell S. Addison, Sasha Hayes, Topul Rali, Tao Wang, Anson V. Koehler, Bill C.H. Chang, Andreas Hofmann, Rohan A. Davis, Robin B. Gasser
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss , Pp 72-79 (2019)
Due to the widespread occurrence and spread of anthelmintic resistance, there is a need to develop new drugs against resistant parasitic nematodes of livestock animals. The Nobel Prize-winning discovery and development of the anti-parasitic drugs ave
Externí odkaz:
https://doaj.org/article/db002d2db68d42d898bbee95ef530872