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pro vyhledávání: '"Rognes IN"'
Autor:
Francis, Emmet A., Laughlin, Justin G., Dokken, Jørgen S., Finsberg, Henrik N. T., Lee, Christopher T., Rognes, Marie E., Rangamani, Padmini
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate, particularl
Externí odkaz:
http://arxiv.org/abs/2405.15968
The activity and dynamics of excitable cells are fundamentally regulated and moderated by extracellular and intracellular ion concentrations and their electric potentials. The increasing availability of dense reconstructions of excitable tissue at ex
Externí odkaz:
http://arxiv.org/abs/2403.04491
The flow of cerebrospinal fluid through the perivascular spaces of the brain is believed to play a crucial role in eliminating toxic waste proteins. While the driving forces of this flow have been enigmatic, experiments have shown that arterial wall
Externí odkaz:
http://arxiv.org/abs/2401.00484
Directional fluid flow in perivascular spaces surrounding cerebral arteries is hypothesized to play a key role in brain solute transport and clearance. While various drivers for pulsatile flow, such as cardiac or respiratory pulsations, are well quan
Externí odkaz:
http://arxiv.org/abs/2310.02429
Autor:
Lars Willas Dreyer, Anders Eklund, Marie E. Rognes, Jan Malm, Sara Qvarlander, Karen-Helene Støverud, Kent-Andre Mardal, Vegard Vinje
Publikováno v:
Fluids and Barriers of the CNS, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Background Infusion testing is an established method for assessing CSF resistance in patients with idiopathic normal pressure hydrocephalus (iNPH). To what extent the increased resistance is related to the glymphatic system is an open questi
Externí odkaz:
https://doaj.org/article/e26d5ad6452b443394cb844469d76bdc
We determine the A(1)-homotopy of the topological cyclic homology of the connective real K-theory spectrum ko. The answer has an associated graded that is a free F_2[v_2^4]-module of rank 52, on explicit generators in stems -1 \le * \le 30. The calcu
Externí odkaz:
http://arxiv.org/abs/2309.11463
In this work, we are interested in solving large linear systems stemming from the Extra-Membrane-Intra (EMI) model, which is employed for simulating excitable tissues at a cellular scale. After setting the related systems of partial differential equa
Externí odkaz:
http://arxiv.org/abs/2308.12145
Autor:
Laughlin, Justin G., Dokken, Jørgen S., Finsberg, Henrik N. T., Francis, Emmet A., Lee, Christopher T., Rognes, Marie E., Rangamani, Padmini
Recent advances in microscopy and 3D reconstruction methods have allowed for characterization of cellular morphology in unprecedented detail, including the irregular geometries of intracellular subcompartments such as membrane-bound organelles. These
Externí odkaz:
http://arxiv.org/abs/2306.07368
The EMI (Extracellular-Membrane-Intracellular) model describes electrical activity in excitable tissue, where the extracellular and intracellular spaces and cellular membrane are explicitly represented. The model couples a system of partial different
Externí odkaz:
http://arxiv.org/abs/2306.03001
Starting from full-dimensional models of solute transport, we derive and analyze multi-dimensional models of time-dependent convection, diffusion, and exchange in and around pulsating vascular and perivascular networks. These models are widely applic
Externí odkaz:
http://arxiv.org/abs/2303.17999