Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rogier Schepers"'
Autor:
Tatjana Geukens, Maxim De Schepper, Wouter Van Den Bogaert, Karen Van Baelen, Marion Maetens, Anirudh Pabba, Amena Mahdami, Sophia Leduc, Edoardo Isnaldi, Ha-Linh Nguyen, Imane Bachir, Maysam Hajipirloo, Gitte Zels, Josephine Van Cauwenberge, Kristien Borremans, Vincent Vandecaveye, Birgit Weynand, Peter Vermeulen, Eleonora Leucci, Maria Francesca Baietti, George Sflomos, Laura Battista, Cathrin Brisken, Patrick W. B. Derksen, Thijs Koorman, Daan Visser, Colinda L. G. J. Scheele, Daniela S. Thommen, Sigrid Hatse, Sarah-Maria Fendt, Evy Vanderheyden, Thomas Van Brussel, Rogier Schepers, Bram Boeckx, Diether Lambrechts, Giuseppe Marano, Elia Biganzoli, Ann Smeets, Ines Nevelsteen, Kevin Punie, Patrick Neven, Hans Wildiers, François Richard, Giuseppe Floris, Christine Desmedt
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Research on metastatic cancer has been hampered by limited sample availability. Here we present the breast cancer post-mortem tissue donation program UPTIDER and show how it enabled sampling of a median of 31 (range: 5-90) metastases and 5-8
Externí odkaz:
https://doaj.org/article/64acb1b4e34a40a5a3f7576042fa573b
Autor:
Wout De Wispelaere, Daniela Annibali, Sandra Tuyaerts, Julie Messiaen, Asier Antoranz, Gautam Shankar, Nikolina Dubroja, Alejandro Herreros‐Pomares, Regina E. M. Baiden‐Amissah, Marie‐Pauline Orban, Marcello Delfini, Emanuele Berardi, Thomas Van Brussel, Rogier Schepers, Gino Philips, Bram Boeckx, Maria Francesca Baietti, Luigi Congedo, Kiave Yune HoWangYin, Emilie Bayon, Anne‐Sophie Van Rompuy, Eleonora Leucci, Sebastien P. Tabruyn, Francesca Bosisio, Massimiliano Mazzone, Diether Lambrechts, Frédéric Amant
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 5, Pp n/a-n/a (2024)
Abstract Background Uterine leiomyosarcomas (uLMS) are aggressive tumours with poor prognosis and limited treatment options. Although immune checkpoint blockade (ICB) has proven effective in some ‘challenging‐to‐treat’ cancers, clinical trial
Externí odkaz:
https://doaj.org/article/96c1f251d0ff4741b236139055f4119b
Autor:
Sarah Cappuyns, Gino Philips, Vincent Vandecaveye, Bram Boeckx, Rogier Schepers, Thomas Van Brussel, Ingrid Arijs, Aurelie Mechels, Ayse Bassez, Francesca Lodi, Joris Jaekers, Halit Topal, Baki Topal, Orian Bricard, Junbin Qian, Eric Van Cutsem, Chris Verslype, Diether Lambrechts, Jeroen Dekervel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable responses in some patients. Using single-cell transcriptomics, we characterize the intra-
Externí odkaz:
https://doaj.org/article/db4b12030ddd4fd095ec4bcc29c92ddb
Autor:
Stéphanie Humblet-Baron, Kristiaan Nackaerts, Johan Vansteenkiste, Diether Lambrechts, Robin Vos, Els Wauters, Jonas Yserbyt, Christophe Dooms, Dries Testelmans, Amelie Franken, Pierre Van Mol, Sam Vanmassenhove, Elena Donders, Rogier Schepers, Thomas Van Brussel, Nico De Crem, Walter De Wever
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)
Background Immune checkpoint inhibitor (ICI)-related pneumonitis is the most frequent fatal immune-related adverse event associated with programmed cell death protein-1/programmed death ligand-1 blockade. The pathophysiology however remains largely u
Externí odkaz:
https://doaj.org/article/f0bd6d17904e4e53b66c0bf815ab4299
Autor:
Catherine Lindon, Rogier Schepers, Philippe Giron, Jacques De Greve, H Begum Akman, M Angeles Ceregido, Luis C Ramos Paez, Esther La Monaca, Carl De Trez, Mara Esposito, Olivier Coux, Gustavo J. Gutierrez
Publikováno v:
Oncogene
Oncogene, Nature Publishing Group, 2020, 39 (37), pp.6009-6023. ⟨10.1038/s41388-020-01396-8⟩
Oncogene, Nature Publishing Group, 2020, 39 (37), pp.6009-6023. ⟨10.1038/s41388-020-01396-8⟩
Aurora B kinase plays essential roles in mitosis. Its protein levels increase before the onset of mitosis and sharply decrease during mitosis exit. The latter decrease is due to a balance between the actions of the E3 ubiquitin ligase anaphase-promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9b3f8eca68c2f65c3ebf08acfad1b1
https://doi.org/10.1038/s41388-020-01396-8
https://doi.org/10.1038/s41388-020-01396-8
Autor:
Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Giusy Di Conza, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-Maria Fendt
Publikováno v:
Cell Reports
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
Fernández-García, J, Franco, F, Parik, S, Altea-Manzano, P, Pane, A A, Broekaert, D, van Elsen, J, Vermeire, I, Schalley, T, Planque, M, van Brussel, T, Schepers, R, Modave, E, Karakach, T K, Carmeliet, P, Lambrechts, D, Ho, P C & Fendt, S M 2022, ' CD8 + T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation ', Cell Reports, vol. 41, no. 7, 111639 . https://doi.org/10.1016/j.celrep.2022.111639
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8+ T cells activated and differentiated in vitro in physiological medium to resolve these metabolic dynamics. We identify a differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765e9de9efea6537277b93c7db336926
Autor:
Juan, Fernández-García, Fabien, Franco, Sweta, Parik, Patricia, Altea-Manzano, Antonino Alejandro, Pane, Dorien, Broekaert, Joke, van Elsen, Ines, Vermeire, Tessa, Schalley, Mélanie, Planque, Thomas, van Brussel, Rogier, Schepers, Elodie, Modave, Tobias K, Karakach, Peter, Carmeliet, Diether, Lambrechts, Ping-Chih, Ho, Sarah-Maria, Fendt
Publikováno v:
Cell reports. 41(7)
T cells dynamically rewire their metabolism during an immune response. We applied single-cell RNA sequencing to CD8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37924a793eba4951994760d13ada5618
https://pubmed.ncbi.nlm.nih.gov/36384124
https://pubmed.ncbi.nlm.nih.gov/36384124