Regulator of oligodendrocyte maturation, miR-219, a potential biomarker for MS

Autor: Ilona B. Bruinsma, Marie van Dijk, Claire Bridel, Timothy van de Lisdonk, Sanne Q. Haverkort, Tessel F. Runia, Lawrence Steinman, Rogier Q. Hintzen, Joep Killestein, Marcel M. Verbeek, Charlotte E. Teunissen, Brigit A. de Jong

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-7 (2017)

Abstract Background Multiple sclerosis (MS) is a demyelinating and degenerative disease of the central nervous system. Normally, demyelination is followed by remyelination, which requires repopulation of a demyelinated area by oligodendrocyte precurs

Externí odkaz: https://doaj.org/article/46b7471ee81b4334b9b23917159eda34

The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults

Autor: C. L. de Mol, Rinze F. Neuteboom, Yym Wong, Rogier Q. Hintzen, Bha Wokke, Tam Siepman, E. D. van Pelt, Dörte Hamann

Publikováno v: Multiple Sclerosis, 26(7), 806-814. SAGE Publications Ltd
Multiple Sclerosis (Houndmills, Basingstoke, England)

Objectives: The aim of this study was to assess the Dutch nationwide incidence of myelin oligodendrocyte glycoprotein (MOG)-IgG-associated acquired demyelinating syndromes (ADS) and to describe the clinical and serological characteristics of these pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f801188742eec1779790bda75647d3e
https://doi.org/10.1177/1352458519845112

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

Autor: Nikolaos A Patsopoulos, Lisa F Barcellos, Rogier Q Hintzen, Catherine Schaefer, Cornelia M van Duijn, Janelle A Noble, Towfique Raj, IMSGC, ANZgene, Pierre-Antoine Gourraud, Barbara E Stranger, Jorge Oksenberg, Tomas Olsson, Bruce V Taylor, Stephen Sawcer, David A Hafler, Mary Carrington, Philip L De Jager, Paul I W de Bakker

Publikováno v: PLoS Genetics, Vol 9, Iss 11, p e1003926 (2013)

The major histocompatibility complex (MHC) region is strongly associated with multiple sclerosis (MS) susceptibility. HLA-DRB1*15:01 has the strongest effect, and several other alleles have been reported at different levels of validation. Using SNP d

Externí odkaz: https://doaj.org/article/6e4e6d6e785f43918ef55c820b6ebf1f

Treatment of MOG antibody associated disorders: results of an international survey

Autor: Romain Marignier, H. J. Kim, Georgina Arrambide, Brigitte Wildemann, Friedemann Paul, Tom Solomon, Kumaran Deiva, Shanthi Viswanathan, Mike Boggild, Russell C. Dale, Sudarshini Ramanathan, Saleel Chandratre, Ilya Kister, Marcelo Matiello, Gulsen Akman-Demir, Rachel Kneen, Olga Ciccarelli, Ingo Kleiter, Venkatraman Karthikeayan, Silvia Tenembaum, Peter Huppke, E Gibbons, Asya I. Wallach, Ichiro Nakashima, Kazuo Fujihara, J. Y. Hor, Marco Aurélio Lana-Peixoto, Marco Capobianco, Philippe Cabre, Maria Margherita Mancardi, Kevin Rostasy, Eric C. Klawiter, Margherita Nosadini, Mar Tintoré, Daniel Whittam, Brenda Banwell, Ayse Altintas, Jeffrey Bennett, Maria Isabel Leite, M. Apiwattankul, Anu Jacob, Brian G. Weinshenker, Wei Qiu, Simon Broadley, Zsolt Illes, Aksel Siva, Maria Pia Amato, Jacqueline Palace, J. de Seze, Douglas Kazutoshi Sato, Bernhard Hemmer, Ming K. Lim, Anne-Katrin Pröbstel, Saif Huda, Michael J. Levy, Benjamin Greenberg, Dean M. Wingerchuk, Yael Hacohen, Orhan Aktas, Lekha Pandit, Sven Jarius, Daniela Pohl, Rogier Q. Hintzen, Anthony Traboulsee

Publikováno v: J Neurol
Journal of Neurology, 267(12), 3565-3577. D. Steinkopff-Verlag
Whittam, D H, Karthikeayan, V, Gibbons, E, Kneen, R, Chandratre, S, Ciccarelli, O, Hacohen, Y, de Seze, J, Deiva, K, Hintzen, R Q, Wildemann, B, Jarius, S, Kleiter, I, Rostasy, K, Huppke, P, Hemmer, B, Paul, F, Aktas, O, Pröbstel, A K, Arrambide, G, Tintore, M, Amato, M P, Nosadini, M, Mancardi, M M, Capobianco, M, Illes, Z, Siva, A, Altintas, A, Akman-Demir, G, Pandit, L, Apiwattankul, M, Hor, J Y, Viswanathan, S, Qiu, W, Kim, H J, Nakashima, I, Fujihara, K, Ramanathan, S, Dale, R C, Boggild, M, Broadley, S, Lana-Peixoto, M A, Sato, D K, Tenembaum, S, Cabre, P, Wingerchuk, D M, Weinshenker, B G, Greenberg, B, Matiello, M, Klawiter, E C, Bennett, J L, Wallach, A I, Kister, I, Banwell, B L, Traboulsee, A, Pohl, D, Palace, J, Leite, M I, Levy, M, Marignier, R, Solomon, T, Lim, M, Huda, S & Jacob, A 2020, ' Treatment of MOG antibody associated disorders : results of an international survey ', Journal of Neurology, vol. 267, no. 12, pp. 3565–3577 . https://doi.org/10.1007/s00415-020-10026-y

Introduction: While monophasic and relapsing forms of myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are increasingly diagnosed world-wide, consensus on management is yet to be developed. Objective: To survey the current gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d243c6172585dcb658a0d3ac7b1c82
http://hdl.handle.net/11577/3356339

The Role of Autoimmunity-Related Gene CLEC16A in the B Cell Receptor-Mediated HLA Class II Pathway

Autor: Jamie van Langelaar, Marvin M van Luijn, John J. Priatel, Steven C Koetzier, S. Marieke van Ham, Tineke Jorritsma, Roos M van der Vuurst de Vries, Marie-José Melief, Liza Rijvers, Annet F Wierenga-Wolf, Rogier Q. Hintzen

Publikováno v: Journal of Immunology, 205(4), 945-956. American Association of Immunologists
Journal of immunology (Baltimore, Md., 205(4), 945-956. American Association of Immunologists

C-type lectin CLEC16A is located next to CIITA, the master transcription factor of HLA class II (HLA-II), at a susceptibility locus for several autoimmune diseases, including multiple sclerosis (MS). We previously found that CLEC16A promotes the biog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f013f99de8caadeb304dd80f5f532860
https://pure.eur.nl/en/publications/8e239d2b-5bd4-4ca3-9bf2-2eefbd975850