Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Rogier M, Reijmers"'
Autor:
Anna Luise Grab, Peter S. Kim, Lukas John, Kamlesh Bisht, Hongfang Wang, Anja Baumann, Helgi Van de Velde, Irene Sarkar, Debarati Shome, Philipp Reichert, Calin Manta, Stefanie Gryzik, Rogier M. Reijmers, Niels Weinhold, Marc S. Raab
Publikováno v:
Cells, Vol 13, Iss 10, p 879 (2024)
Current treatment strategies for multiple myeloma (MM) are highly effective, but most patients develop relapsed/refractory disease (RRMM). The anti-CD38/CD3xCD28 trispecific antibody SAR442257 targets CD38 and CD28 on MM cells and co-stimulates CD3 a
Externí odkaz:
https://doaj.org/article/8503b9abaeac4cfa9e1744711dde30b6
Autor:
Simon Thomas, Julia Taylor, Manuel Rodriguez-Justo, Kwee Yong, Mathieu Ferrari, Shimobi Onuoha, Sonja Zweegman, Rakesh Popat, Lydia Lee, Wen Chean Lim, Daria Galas-Filipowicz, Kent Fung, Dominic Patel, Zulaikha Akbar, Elena Alvarez Mediavilla, Patrycja Wawrzyniecka, Debarati Shome, Rogier M Reijmers, Trillian Gregg, Leigh Wood, William Day, Virginie Cerec, Shaun Cordoba, Nushmia Khokhar, Vijay Peddareddigari, Muhammad Al-Hajj, Jim Cavet, Martin Pule
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background We used a proliferating ligand (APRIL) to construct a ligand-based third generation chimeric antigen receptor (CAR) able to target two myeloma antigens, B-cell maturation antigen (BCMA) and transmembrane activator and CAML interactor.Metho
Externí odkaz:
https://doaj.org/article/8067650d1c374058a81e8dfb09c80620
Autor:
Sharyn Thomas, Fiyaz Mohammed, Rogier M. Reijmers, Annemarie Woolston, Theresa Stauss, Alan Kennedy, David Stirling, Angelika Holler, Louisa Green, David Jones, Katherine K. Matthews, David A. Price, Benjamin M. Chain, Mirjam H. M. Heemskerk, Emma C. Morris, Benjamin E. Willcox, Hans J. Stauss
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Increasing TCR cell surface expression can potentiate T cell responses to low-concentrations of antigen. Here the authors identify aminoacids in human TCR variable domains that impact its surface expression, and demonstrate how editing these residues
Externí odkaz:
https://doaj.org/article/b91ffe9fd06f4dd8ae5b0aa7c12c5d8e
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/53a789a7aaea40f9bb438a2aa6b89092
Autor:
Reza Nadafi, Catarina Gago de Graça, Eelco D. Keuning, Jasper J. Koning, Sander de Kivit, Tanja Konijn, Sandrine Henri, Jannie Borst, Rogier M. Reijmers, Lisa G.M. van Baarsen, Reina E. Mebius
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4110-4123.e4 (2020)
Summary: Within lymph nodes (LNs), T follicular helper (TFH) cells help B cells to produce antibodies, which can either be protective or autoreactive. Here, we demonstrate that murine LN stromal cells (LNSCs) suppress the formation of autoreactive TF
Externí odkaz:
https://doaj.org/article/2b93e3f59882461b8aeb6a0f5572beb0
Autor:
Yotam E. Bar-Ephraim, Ferry Cornelissen, Natalie Papazian, Tanja Konijn, Remco M. Hoogenboezem, Mathijs A. Sanders, Bart A. Westerman, Mehmet Gönültas, Jaap Kwekkeboom, Joke M.M. Den Haan, Rogier M. Reijmers, Reina E. Mebius, Tom Cupedo
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 823-833 (2017)
A substantial number of human and mouse group 3 innate lymphoid cells (ILC3s) reside in secondary lymphoid organs, yet the phenotype and function of these ILC3s is incompletely understood. Here, we employed an unbiased cross-tissue transcriptomic app
Externí odkaz:
https://doaj.org/article/2052fe975f11466bbffd54387d2953fa
Autor:
Jordi Berenguer, Tonny Lagerweij, Xi Wen Zhao, Sophie Dusoswa, Petra van der Stoop, Bart Westerman, Mark C. de Gooijer, Marloes Zoetemelk, Anoek Zomer, Matheus H. W. Crommentuijn, Laurine E. Wedekind, Àlan López-López, Alberta Giovanazzi, Marina Bruch-Oms, Ida H. van der Meulen-Muileman, Rogier M. Reijmers, Toin H. van Kuppevelt, Juan-Jesús García-Vallejo, Yvette van Kooyk, Bakhos A. Tannous, Pieter Wesseling, Danijela Koppers-Lalic, W. Peter Vandertop, David P. Noske, Victor W. van Beusechem, Jacco van Rheenen, D. Michiel Pegtel, Olaf van Tellingen, Thomas Wurdinger
Publikováno v:
Journal of Extracellular Vesicles, Vol 7, Iss 1 (2018)
Cancer cells release extracellular vesicles (EVs) that contain functional biomolecules such as RNA and proteins. EVs are transferred to recipient cancer cells and can promote tumour progression and therapy resistance. Through RNAi screening, we ident
Externí odkaz:
https://doaj.org/article/0383b1c10fde4f49b4ec2946fa595f3c
Autor:
Reza Nadafi, Jasper J. Koning, Henrike Veninga, Xanthi N. Stachtea, Tanja Konijn, Antonie Zwiers, Anders Malmström, Joke M. M. den Haan, Reina E. Mebius, Marco Maccarana, Rogier M. Reijmers
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
For full activation of naïve adaptive lymphocytes in skin-draining lymph nodes (LNs), presentation of peptide:MHC complexes by LN-resident and skin-derived dendritic cells (DCs) that encountered antigens (Ags) is an absolute prerequisite. To get to
Externí odkaz:
https://doaj.org/article/61d2a34a46114db18d982be5047a0eab
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167555 (2016)
The stromal compartment of secondary lymphoid organs is classicaly known for providing a mechanical scaffold for the complex interactions between hematopoietic cells during immune activation as well as for providing a niche which is favorable for sur
Externí odkaz:
https://doaj.org/article/d9155d9b1a5641b5873bd0de141a977f
Development of follicular dendritic cells in lymph nodes depends on retinoic acid mediated signaling
Autor:
Reina E. Mebius, Tanja Konijn, Jasper J. Koning, Carl F. Ware, Anusha Rajaraman, Eugene C. Butcher, Junliang Pan, Rogier M. Reijmers
Publikováno v:
Koning, J J, Rajaraman, A, Reijmers, R M, Konijn, T, Pan, J, Ware, C F, Butcher, E C & Mebius, R E 2021, ' Development of follicular dendritic cells in lymph nodes depends on retinoic acid mediated signaling ', Development (Cambridge), vol. 148, no. 20 . https://doi.org/10.1242/dev.199713
Development
Development (Cambridge), 148(20). Company of Biologists Ltd
Development
Development (Cambridge), 148(20). Company of Biologists Ltd
Specialized stromal cells occupy and help define B- and T cell domains, which is crucial for proper functioning of our immune system. Signaling through lymphotoxin and TNF-receptors is crucial for development of different stromal subsets which are th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d55672104eed885a665a8e68c922e8
https://research.vumc.nl/en/publications/7eb344ab-f3b0-4a0b-b7d9-a0a172eb59db
https://research.vumc.nl/en/publications/7eb344ab-f3b0-4a0b-b7d9-a0a172eb59db
