Validating human and mouse tissues commonly used in atherosclerosis research with coronary and aortic reference tissue: similarities but profound differences in disease initiation and plaque stability

Autor: Rogier A. van Dijk, MD, PhD, Robert Kleemann, PhD, Alexander F. Schaapherder, MD, PhD, Antoon van den Bogaerdt, PhD, Ulf Hedin, MD, PhD, Ljubica Matic, PhD, Jan H.N. Lindeman, MD, PhD

Publikováno v: JVS - Vascular Science, Vol 4, Iss , Pp 100118- (2023)

Objective: Characterization of the atherosclerotic process fully relies on histological evaluation and staging through a consensus grading system. So far, a head-to-head comparison of atherosclerotic process in experimental models and tissue resource

Externí odkaz: https://doaj.org/article/1bddda1b4bf240c18304664ae53e7d63

Systematic Evaluation of the Cellular Innate Immune Response During the Process of Human Atherosclerosis

Autor: Rogier A. van Dijk, Kevin Rijs, Anouk Wezel, Jaap F. Hamming, Frank D. Kolodgie, Renu Virmani, Alexander F. Schaapherder, Jan H. N. Lindeman

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 6 (2016)

BackgroundThe concept of innate immunity is well recognized within the spectrum of atherosclerosis, which is primarily dictated by macrophages. Although current insights to this process are largely based on murine models, there are fundamental differ

Externí odkaz: https://doaj.org/article/ca207222b0744e95aeffcbfefe359ec6

Leukocyte Dynamics during the Evolution of Human Coronary Atherosclerosis

Autor: Antoon J. van den Bogaerdt, Jan H.N. Lindeman, Connie J. van Rhijn, Marlieke Geerts, Melissa Zuiderwijk, Jaap F. Hamming, Rogier A. van Dijk

Publikováno v: The American Journal of Pathology. 188:1524-1529

Atherosclerosis is a complex process with strong inflammatory component. We developed a straightforward sevenfold staining protocol for simultaneous assessment of dominant leukocyte classes, vascularization, and expression of the putative foam cell m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cba1f0a090e98632c94a5844a6a9e7fe
https://doi.org/10.1016/j.ajpath.2018.03.011

Qualitative evaluation of coronary atherosclerosis in a large cohort of young and middle-aged Dutch tissue donors implies that coronary thrombo-embolic manifestations are stochastic

Autor: Alain J. van Gool, J H N Lindeman, Antoon J. van den Bogaerdt, Rogier A. van Dijk, Marlieke Geerts, Jaap F. Hamming, Luuk Hulsbos, Alexander F. Schaapherder

Publikováno v: PLoS ONE
Plos One, 11, 13, e0207943
PLoS ONE, 13(11)
PLoS One, 13, 11, pp. 1-13
PLoS One, 13, 1-13
PLoS ONE, Vol 13, Iss 11, p e0207943 (2018)

BACKGROUND AND AIMS:With the intention to gain support for the hypothesis that incident ischemic complications of atherosclerotic disease involve a stochastic aspect, we performed a histological, qualitative evaluation of the epidemiology of coronary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1798a77fe31b2bcf562e0450c88caa0d
http://resolver.tudelft.nl/uuid:9e1ff021-dc80-405b-b41b-85abb56bd491

Histological evaluation disqualifies IMT and calcification scores as surrogates for grading coronary and aortic atherosclerosis

Autor: Sander Verhage, Jan H.N. Lindeman, Ad J.J.C. Bogers, Antoon J. van den Bogaerdt, Jaap F. Hamming, Armelle J.A. Meershoek, Rogier A. van Dijk, Alexander F. Schaapherder

Publikováno v: International Journal of Cardiology, 224:328. Elsevier Ireland Ltd
International Journal of Cardiology, 224, 328-334

Background/objectivesCarotid intimal media thickness (IMT) and coronary calcium scores (CCS) are thought to reflect atherosclerotic burden. The validity of this assumption for IMT is challenged by recent meta-analyses; for CCS by absence of a relatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3293ec5d177b3ec845914c3745c85fed
https://hdl.handle.net/1887/111826