Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Rogier, Ten Hoopen"'
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly und
Externí odkaz:
https://doaj.org/article/70172e9506b8433ca7874eabf4b5a777
Autor:
Alvin Wei Tian Ng, Dylan Peter McClurg, Ben Wesley, Shahriar A. Zamani, Emily Black, Ahmad Miremadi, Olivier Giger, Rogier ten Hoopen, Ginny Devonshire, Aisling M. Redmond, Nicola Grehan, Sriganesh Jammula, Adrienn Blasko, Xiaodun Li, Samuel Aparicio, Simon Tavaré, Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, Karol Nowicki-Osuch, Rebecca C. Fitzgerald
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/e131446b35e94c42af2e34ae89cd9a66
Autor:
Philip S. Robinson, Laura E. Thomas, Federico Abascal, Hyunchul Jung, Luke M. R. Harvey, Hannah D. West, Sigurgeir Olafsson, Bernard C. H. Lee, Tim H. H. Coorens, Henry Lee-Six, Laura Butlin, Nicola Lander, Rebekah Truscott, Mathijs A. Sanders, Stefanie V. Lensing, Simon J. A. Buczacki, Rogier ten Hoopen, Nicholas Coleman, Roxanne Brunton-Sim, Simon Rushbrook, Kourosh Saeb-Parsy, Fiona Lalloo, Peter J. Campbell, Iñigo Martincorena, Julian R. Sampson, Michael R. Stratton
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Inherited mutations in MUTYH have been shown to predispose patients to colorectal cancers. Here, the authors show that MUTYH mutations lead to an increased somatic base substitution mutation rate in normal intestinal epithelial cells, which is the li
Externí odkaz:
https://doaj.org/article/c14b563faf084d9f9abf9b953d1b62bf
Autor:
Seong Keat Cheah, Chad Ramese Bisambar, Deborah Pitfield, Olivier Giger, Rogier ten Hoopen, Jose-Ezequiel Martin, Graeme R Clark, Soo-Mi Park, Craig Parkinson, Benjamin G Challis, Ruth T Casey
Publikováno v:
Endocrinology, Diabetes & Metabolism Case Reports, Vol 1, Iss 1, Pp 1-7 (2021)
A 38-year-old female was identified as carrying a heterozygous pathogenic MEN1 variant (c.1304delG) through predictive genetic testing, following a diagnosis of familial hyperparathyroidism. Routine screening for parathyroid and pituitary disease was
Externí odkaz:
https://doaj.org/article/c9f0caffde984c3cbe47f04d220f4b90
Autor:
Luigi Aloj, Olivier Giger, Iosif A. Mendichovszky, Ben G. Challis, Meytar Ronel, Ines Harper, Heok Cheow, Rogier ten Hoopen, Deborah Pitfield, Ferdia A. Gallagher, Bala Attili, Mary McLean, Robin L. Jones, Palma Dileo, Venkata Ramesh Bulusu, Eamonn R. Maher, Ruth T. Casey
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Background [68 Ga]Ga-DOTATATE PET/CT is now recognised as the most sensitive functional imaging modality for the diagnosis of well-differentiated neuroendocrine tumours (NET) and can inform treatment with peptide receptor radionuclide therap
Externí odkaz:
https://doaj.org/article/3128c75f9b434cb5bedd12ba6834b549
Autor:
Ruth T. Casey, Rogier ten Hoopen, Eguzkine Ochoa, Benjamin G. Challis, James Whitworth, Philip S. Smith, Jose Ezequiel Martin, Graeme R. Clark, Fay Rodger, Mel Maranian, Kieren Allinson, Basetti Madhu, Thomas Roberts, Luis Campos, Joanne Anstee, Soo-Mi Park, Alison Marker, Colin Watts, Venkata R. Bulusu, Olivier T. Giger, Eamonn R. Maher
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Abstract The enzyme succinate dehydrogenase (SDH) functions in the citric acid cycle and loss of function predisposes to the development of phaeochromocytoma/paraganglioma (PPGL), wild type gastrointestinal stromal tumour (wtGIST) and renal cell carc
Externí odkaz:
https://doaj.org/article/e8bf863475e349e4b6af0bc8e9781f47
Autor:
Olivier T, Giger, Rogier, Ten Hoopen, David, Shorthouse, Shukri, Abdullahi, Venkata Ramesh, Bulusu, Saili, Jadhav, Eamonn R, Maher, Ruth T, Casey
Publikováno v:
Journal of clinical pathology.
Wild-type gastrointestinal stromal tumours (wtGIST) are frequently caused by inherited pathogenic variants, or somatic alterations in the succinate dehydrogenase subunit genes (MGMT methylation analysis was performed on 65 tumour samples including 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58fc52063a18d35b711423d98c5cdc91
https://pubmed.ncbi.nlm.nih.gov/36198483
https://pubmed.ncbi.nlm.nih.gov/36198483
Autor:
Claire Faulkner, Kirsty Russell, Olivier Giger, Rogier ten Hoopen, Ruth T Casey, Newton A C S Wong
Publikováno v:
Journal of Clinical Pathology. 74:194-197
AimThere is no known specific biomarker or genetic signal for quadruple wild-type (qWT) gastrointestinal stromal tumours (GISTs). By next-generation sequencing (NGS) of different GIST subgroups, this study aimed to characterise such a biomarker espec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06b4d5136aa0440c44dbf4626c0d8b3
https://doi.org/10.1136/jclinpath-2020-206613
https://doi.org/10.1136/jclinpath-2020-206613
Autor:
Inigo Martincorena, Hannah West, Philip S. Robinson, Federico Abascal, Hyunchul Jung, Laura Butlin, Nicola Lander, Laura E. Thomas, Roxanne Brunton-Sim, Rogier ten Hoopen, Tim H. H. Coorens, Michael R. Stratton, Henry Lee-Six, Simon M. Rushbrook, Kourosh Saeb-Parsy, Mathijs A. Sanders, Bernard C H Lee, Luke M. R. Harvey, Fiona Lalloo, Nicholas Coleman, Peter J. Campbell, Sigurgeir Olafsson, Simon J.A. Buczacki, Julian R. Sampson, Stefanie V Lensing
Cellular DNA damage caused by reactive oxygen species is repaired by the base excision repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic MUTYH mutations cause predisposition to colorectal adenomas and carcinoma. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3cad32a92d4fb21b709b32ce51875aa
https://doi.org/10.1101/2021.10.20.465093
https://doi.org/10.1101/2021.10.20.465093
Autor:
Olivier T Giger, Rogier ten Hoopen, David Shorthouse, Shukri Abdullahi, Venkata Ramesh Bulusu, Saili Jadhav, Eamonn R Maher, Ruth T Casey
Publikováno v:
Journal of Clinical Pathology. :jcp-2022
AimsWild-type gastrointestinal stromal tumours (wtGIST) are frequently caused by inherited pathogenic variants, or somatic alterations in the succinate dehydrogenase subunit genes (SDHx). Succinate dehydrogenase is a key enzyme in the citric acid cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8340ecaad9aa42f8c6db06b6548d40a2
https://doi.org/10.1136/jcp-2022-208462
https://doi.org/10.1136/jcp-2022-208462