Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Rogerio M. Castilho"'
Autor:
Alexandra E. Herzog, Kristy A. Warner, Zhaocheng Zhang, Emily Bellile, Meera A. Bhagat, Rogerio M. Castilho, Gregory T. Wolf, Peter J. Polverini, Alexander T. Pearson, Jacques E. Nör
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Abstract Despite major progress in elucidating the pathobiology of head and neck squamous cell carcinoma (HNSCC), the high frequency of disease relapse correlates with unacceptably deficient patient survival. We previously showed that cancer stem-lik
Externí odkaz:
https://doaj.org/article/3707949541ef4d9b938398d1dec5cc67
Autor:
Carlos H. V. Nascimento-Filho, Ericka J. D. Silveira, Eny M. Goloni-Bertollo, Lelia Batista de Souza, Cristiane H. Squarize, Rogerio M. Castilho
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-11 (2020)
Abstract Background The skin is the largest organ of the human body. Upon injury, the skin triggers a sequence of signaling pathways that induce epithelial proliferation, migration, and ultimately, the re-establishment of the epithelial barrier. Our
Externí odkaz:
https://doaj.org/article/4ba4600238e2414e99cf61a0e67f99cc
Autor:
Chiara Zagni, Luciana O. Almeida, Tarek Balan, Marco T. Martins, Luciana K. Rosselli-Murai, Petros Papagerakis, Rogerio M. Castilho, Cristiane H. Squarize
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 304-314 (2017)
Tissue integrity requires constant maintenance of a quiescent, yet responsive, population of stem cells. In the skin, hair follicle stem cells (HFSCs) that reside within the bulge maintain tissue homeostasis in response to activating cues that occur
Externí odkaz:
https://doaj.org/article/92587c1e982840899a6a06077337108e
Autor:
Luciana O. Almeida, Douglas M. Guimarães, Manoela D. Martins, Marco A.T. Martins, Kristy A. Warner, Jacques E. Nör, Rogerio M. Castilho, Cristiane H. Squarize
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 94-105 (2017)
Adenoid cystic carcinoma (ACC) is an uncommon malignancy of the salivary glands that is characterized by local recurrence and distant metastasis due to its resistance to conventional therapy. Platinum-based therapies have been extensively explored as
Externí odkaz:
https://doaj.org/article/2a9d76f9d8744989a5764d2441394365
Publikováno v:
Stem Cells International, Vol 2019 (2019)
A frequent observation in several malignancies is the development of resistance to therapy that results in frequent tumor relapse and metastasis. Much of the tumor resistance phenotype comes from its heterogeneity that halts the ability of therapeuti
Externí odkaz:
https://doaj.org/article/1bafb286eabb4262a146516c26307dd7
Autor:
Luciana O. Almeida, Aline C. Abrahao, Luciana K. Rosselli-Murai, Fernanda S. Giudice, Chiara Zagni, Andreia M. Leopoldino, Cristiane H. Squarize, Rogerio M. Castilho
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 96-104 (2014)
Cisplatin-based chemotherapy is the standard treatment of choice for head and neck squamous cell carcinoma (HNSCC). The efficiency of platinum-based therapies is directly influenced by the development of tumor resistance. Multiple signaling pathways
Externí odkaz:
https://doaj.org/article/ed24c446bc314a80a99a6b2c1641b8ab
Autor:
Cristiane H. Squarize, Rogerio M. Castilho, Virote Sriuranpong, Decio S. Pinto, Jr., Jorge Silvio Gutkind
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 9, Pp 733-746 (2006)
The development of head and neck squamous cell carcinoma (HNSCC) involves the accumulation of genetic and epigenetic alterations in tumor-suppressor proteins, together with the persistent activation of growth-promoting signaling pathways. The activat
Externí odkaz:
https://doaj.org/article/318ab2ba6a764fe1a8a71b58743ad63d
Publikováno v:
Journal of Oral Pathology & Medicine. 52:339-341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43358b00467aa1a2fdc1552536aa22ac
https://doi.org/10.1111/jop.13407
https://doi.org/10.1111/jop.13407
Autor:
Lena, Larsson, Nolan M, Kavanagh, Trang V N, Nguyen, Rogerio M, Castilho, Tord, Berglundh, William V, Giannobile
Publikováno v:
Periodontology 2000. 90:125-137
Periodontitis is a disease characterized by tooth-associated microbial biofilms that drive chronic inflammation and destruction of periodontal-supporting tissues. In some individuals, disease progression can lead to tooth loss. A similar condition ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d7aec79be5e4e263eca65b6172331
https://doi.org/10.1111/prd.12453
https://doi.org/10.1111/prd.12453
Autor:
Jacques E. Nör, Shaomeng Wang, Alexander T. Pearson, Rogerio M. Castilho, Christopher A. Moskaluk, Michael J. Wick, Joseph Helman, Douglas B. Chepeha, Matthew E. Spector, Scott A. McLean, Zhaocheng Zhang, Manoela D. Martins, Gerson A. Acasigua, Felipe Nör, Kristy A. Warner
Purpose: There are no effective treatment options for patients with advanced adenoid cystic carcinoma (ACC). Here, we evaluated the effect of a new small molecule inhibitor of the MDM2–p53 interaction (MI-773) in preclinical models of ACC.Experimen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950905da0ed9e50c8465852ab595c031
https://doi.org/10.1158/1078-0432.c.6523376
https://doi.org/10.1158/1078-0432.c.6523376
