Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Roger W. Roeske"'
Autor:
Zhenping Tian, Roger W. Roeske
Publikováno v:
International Journal of Peptide and Protein Research. 37:425-429
A novel guanidination method of converting a peptide side chain amino group to a guanidino group on a solid support is described. Four guanidinating reagents were evaluated using a model tetrapeptide attached to a polystyrene resin. Experimental data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684e0851d588542f531b8100048dcd2d
https://doi.org/10.1111/j.1399-3011.1991.tb00757.x
https://doi.org/10.1111/j.1399-3011.1991.tb00757.x
Publikováno v:
International Journal of Peptide and Protein Research. 43:471-476
We have examined the effect of C α -methyl groups on the conformational ensemble of GnRH analog peptides by comparing 1 2D NMR data from two analogs, Ac-D-Nal 1 -D-4-Cl-C α -Me-Phe 2 -D-Pal 3 -Ser 4 -Tyr 5 -D-Arg 6 -Leu 7 -Arg 8 -Pro 9 -D-Ala 10 -N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08f428bc7dc9f4d97cc74da6dd27aa7b
https://doi.org/10.1111/j.1399-3011.1994.tb00546.x
https://doi.org/10.1111/j.1399-3011.1994.tb00546.x
Publikováno v:
International Journal of Peptide and Protein Research. 40:119-126
Optically pure L-(+)-C alpha-methyl-arginine and D-(-)-C alpha-methyl-arginine were synthesized. Experimental results indicated that DL-C alpha-methyl-arginine methyl ester could be resolved by trypsin, but workup posed a technical difficulty. Chemic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02aedb2f279be5a2f71f90fdfe33750
https://doi.org/10.1111/j.1399-3011.1992.tb01459.x
https://doi.org/10.1111/j.1399-3011.1992.tb01459.x
Publikováno v:
International Journal of Peptide and Protein Research. 42:155-158
A practical and convenient procedure for making phosphotyrosine-containing peptides by the solid-phase method was developed. Phosphotyrosine was incorporated via Boc-Tyr(PO3Bzl2)-OH. The completed peptide was cleaved from the solid support by treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::157f9d3a632102d0d6266d8aec42bbfd
https://doi.org/10.1111/j.1399-3011.1993.tb00491.x
https://doi.org/10.1111/j.1399-3011.1993.tb00491.x
Publikováno v:
Biophysical Journal. 90:947-955
The beta-barrel and beta-helix formation, as in porins and gramicidin, respectively, represent two distinct mechanisms for ion channel formation by beta-sheet proteins in membranes. The design of beta-barrel proteins is difficult due to incomplete un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740428dac74b0a1eb32f157c2f751e20
https://doi.org/10.1529/biophysj.105.072751
https://doi.org/10.1529/biophysj.105.072751
Publikováno v:
Biochemical and Biophysical Research Communications. 330:585-590
Design of simple protein structures represents the essential first step toward novel macromolecules and understanding the basic principles of protein folding. Our work focuses on the ion channel formation and structure of peptides having a repeated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465b9786bb8caf03b4c5961e4ad2f47a
https://doi.org/10.1016/j.bbrc.2005.02.184
https://doi.org/10.1016/j.bbrc.2005.02.184
Publikováno v:
Bioconjugate Chemistry. 16:458-464
A pair of ICAT reagents, N-(13-iodoacetamido-2,2,3,3,11,11,12,12-octadeutero-4,7,10-trioxa-tridecanyl)biotinamide (8d, ICAT-d(8)) and N-(13-iodoacetamido-4,7,10-trioxa-tridecanyl)biotinamide (8c, ICAT-d(0)), and an alternative pair of ICAT reagents,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa18bbcce845cae9b34b6719ee48830b
https://doi.org/10.1021/bc049777y
https://doi.org/10.1021/bc049777y
Publikováno v:
Analytical Biochemistry. 332:168-177
Cell membrane-associated folate receptors are selectively overexpressed in certain human tumors. The high affinity of folic acid for folate receptors provides a unique opportunity to use folic acid as a targeting ligand to deliver chemotherapeutic ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4b51a5540ff73deb640632d220479a
https://doi.org/10.1016/j.ab.2004.05.034
https://doi.org/10.1016/j.ab.2004.05.034
Publikováno v:
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life). 54:67-72
Inappropriate expression of fibroblast growth factors (FGFs) or activation of FGF receptors (FGFRs) could contribute to several human angiogenic pathologies. In an attempt to design antagonists of FGF, we developed a screening procedure for identifyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afa190f773983069121c08ff5f75d9c0
https://doi.org/10.1080/15216540214308
https://doi.org/10.1080/15216540214308
Two Mutations in Extracellular Loop 2 of the Human GnRH Receptor Convert an Antagonist to an Agonist
Autor:
Robert P. Millar, Brigitte E. Troskie, Colleen A. Flanagan, Nicola Illing, Thomas R. Ott, Roger W. Roeske
Publikováno v:
Molecular Endocrinology. 16:1079-1088
GnRH regulates the reproductive system through cognate G protein-coupled receptors in vertebrates. Certain GnRH analogs that are antagonists at mammalian receptors behave as agonists at Xenopus laevis and chicken receptors. This phenomenon provides t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5d58cb8bba24c5ad2d01ff60cb36cf
https://doi.org/10.1210/mend.16.5.0824
https://doi.org/10.1210/mend.16.5.0824