Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Roger W. Hunter"'
Autor:
Samantha F. Moore, Ejaife O. Agbani, Andreas Wersäll, Alastair W. Poole, Chris M. Williams, Xiaojuan Zhao, Yong Li, James L. Hutchinson, Roger W. Hunter, Ingeborg Hers
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10656 (2021)
One of the mechanisms by which PI3 kinase can regulate platelet function is through phosphorylation of downstream substrates, including glycogen synthase kinase-3 (GSK3)α and GSK3β. Platelet activation results in the phosphorylation of an N-termina
Externí odkaz:
https://doaj.org/article/61cd90332d4243aa9ac67f91886d4c35
Autor:
Alastair W. Poole, Ingeborg Hers, Yong Li, Roger W. Hunter, Samantha F. Moore, James L Hutchinson, Christopher Williams, Xiaojuan Zhao, E.O. Agbani, Andreas Wersäll
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 10656, p 10656 (2021)
Volume 22
Issue 19
Moore, S F, Agbani, E O, Wersall, J A, Poole, A W, Williams, C M, Zhao, X, Li, Y, Hutchinson, J L, Hunter, R W & Hers, I 2021, ' Opposing roles of gsk3α and gsk3β phosphorylation in platelet function and thrombosis ', International Journal of Molecular Sciences, vol. 22, no. 19, 10656, pp. 10656 . https://doi.org/10.3390/ijms221910656
International Journal of Molecular Sciences, Vol 22, Iss 10656, p 10656 (2021)
Volume 22
Issue 19
Moore, S F, Agbani, E O, Wersall, J A, Poole, A W, Williams, C M, Zhao, X, Li, Y, Hutchinson, J L, Hunter, R W & Hers, I 2021, ' Opposing roles of gsk3α and gsk3β phosphorylation in platelet function and thrombosis ', International Journal of Molecular Sciences, vol. 22, no. 19, 10656, pp. 10656 . https://doi.org/10.3390/ijms221910656
One of the mechanisms by which PI3 kinase can regulate platelet function is through phosphorylation of downstream substrates, including glycogen synthase kinase-3 (GSK3)α and GSK3β. Platelet activation results in the phosphorylation of an N-termina
Autor:
Roger W. Hunter, Louise Lantier, Elton Zeqiraj, Kei Sakamoto, Curtis C. Hughey, Mark Peggie, Elias Immanuel Ordell Sundelin, David H. Wasserman, Frank Sicheri, Niels Jessen
Publikováno v:
Nature medicine
Hunter, R W, Hughey, C C, Lantier, L, Sundelin, E I, Peggie, M, Zeqiraj, E, Sicheri, F, Jessen, N, Wasserman, D H & Sakamoto, K 2018, ' Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase ', Nature Medicine, vol. 24, no. 9, pp. 1395-1406 . https://doi.org/10.1038/s41591-018-0159-7
Hunter, R W, Hughey, C C, Lantier, L, Sundelin, E I, Peggie, M, Zeqiraj, E, Sicheri, F, Jessen, N, Wasserman, D H & Sakamoto, K 2018, ' Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase ', Nature Medicine, vol. 24, no. 9, pp. 1395-1406 . https://doi.org/10.1038/s41591-018-0159-7
Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its precise mechanism of action remains unclear. Metformin exerts its anti-hyperglycemic action primarily through lowering of hepatic glucose production (HGP).
Autor:
Shahida Mallah, Vijayasameerah Vijayaragavan, Samantha F. Moore, Lucy J Goudswaard, Ingeborg Hers, Kamila M. Sledz, Roger W. Hunter, Christopher Williams
Publikováno v:
Cellular signalling. 68
Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family, which recently has been implicated in the regulation of p38 MAPK/PLA2/thromboxane (TxA2) generation, as well as P2Y12 signalling
Autor:
Samantha F. Moore, Kamila M. Śledź, Roger W. Hunter, Thomas A. Blair, Ingeborg Hers, Tom N. Durrant
Publikováno v:
Biochemical Pharmacology. 177:113975
Background and Purpose Rapamycin is a potent immunosuppressant and anti-proliferative agent used clinically to prevent organ transplant rejection and for coating coronary stents to counteract restenosis. Rapamycin complexes with the immunophilin FKBP
Autor:
N Barile, Marie-Blanche Onselaer, Luc Bertrand, Stéphane Eeckhoudt, L-M Jacquet, Cécile Oury, Kei Sakamoto, Christophe Beauloye, Roger W. Hunter, Jean-Louis Vanoverschelde, Sandrine Horman, Benoit Viollet, Nicole Morel, Christelle Lecut
Publikováno v:
Journal of thrombosis and haemostasis : JTH, Vol. 12, no.6, p. 973-86 (2014)
BACKGROUND: Platelet activation requires sweeping morphologic changes, supported by contraction and remodeling of the platelet actin cytoskeleton. In various other cell types, AMP-activated protein kinase (AMPK) controls the phosphorylation state of
Publikováno v:
Journal of Thrombosis and Haemostasis
Summary Background Rapamycin, an inhibitor of mammalian target of rapamycin complex-1 (mTORC1), reduces platelet spreading, thrombus stability, and clot retraction. Despite an important role of mTORC1 in platelet function, little is known about how i
Autor:
Wang Wang, Kei Sakamoto, Rong Tian, Jason Xu, Roger W. Hunter, Yu Ying Yang, Guohua Gong, Stephen C. Kolwicz, Lorena Garcia-Menendez, Maengjo Kim
Publikováno v:
Circulation Research. 114:966-975
Rationale: AMP-activated protein kinase is a master regulator of cell metabolism and an attractive drug target for cancer and metabolic and cardiovascular diseases. Point mutations in the regulatory γ2-subunit of AMP-activated protein kinase (encode
Autor:
Jacob Jeppesen, Annette K. Serup, David M. Thomson, Niels Jessen, Klaus Qvortrup, Roger W. Hunter, Kasper Thorsen, Andreas Børsting Jordy, Kei Sakamoto, Christian Pehmøller, Jason R.B. Dyck, Clara Prats, Lykke Sylow, Stine J. Maarbjerg, Andreas M. Fritzen, Peter Schjerling, Erik A. Richter, Bente Kiens, Jørgen F. P. Wojtaszewski
Publikováno v:
Diabetes
Jeppesen, J F, Maarbjerg, S J, Jordy, A B, Fritzen, A M, Pehmøller, C K, Hansen, L S, Serup, A K L, Jessen, N, Thorsen, K, Prats, C, Qvortrup, K, Dyck, J R B, Hunter, R W, Sakamoto, K, Thomson, D M, Schjerling, P, Wojtaszewski, J, Richter, E & Kiens, B 2013, ' LKB1 regulates lipid oxidation during exercise independently of AMPK ', Diabetes, vol. 62, no. 5, pp. 1490-9 . https://doi.org/10.2337/db12-1160
Jeppesen, J F, Maarbjerg, S J, Jordy, A B, Fritzen, A M, Pehmøller, C K, Hansen, L S, Serup, A K L, Jessen, N, Thorsen, K, Prats, C, Qvortrup, K, Dyck, J R B, Hunter, R W, Sakamoto, K, Thomson, D M, Schjerling, P, Wojtaszewski, J, Richter, E & Kiens, B 2013, ' LKB1 regulates lipid oxidation during exercise independently of AMPK ', Diabetes, vol. 62, no. 5, pp. 1490-9 . https://doi.org/10.2337/db12-1160
Lipid metabolism is important for health and insulin action, yet the fundamental process of regulating lipid metabolism during muscle contraction is incompletely understood. Here, we show that liver kinase B1 (LKB1) muscle-specific knockout (LKB1 MKO
Autor:
Ingeborg Hers, Andrew D Mumford, Alastair W. Poole, Sarah K Westbury, Roger W. Hunter, Samreen Siddiq, Joshua Savage, Matthew T. Harper, Samantha F. Moore
Publikováno v:
Blood. 121:1209-1219
Patients with myeloproliferative disorders (MPDs), such as essential thrombocythemia (ET) have increased risk of thrombosis and bleeding, which are major sources of morbidity and mortality. Most MPD patients have a gain of function mutation in Janus