Výsledky vyhledávání - "Roger W. Howell"

Akademický článek

Late effects of heavy-ion space radiation on splenocyte subpopulations and NK cytotoxic function

Autor: Calvin N. Leung, Donna M. Howell, Sonia M. De Toledo, Edouard I. Azzam, Roger W. Howell

Publikováno v: Frontiers in Astronomy and Space Sciences, Vol 9 (2022)

Introduction: With current goals of increased space exploration and travel to Mars, there has been great interest in understanding the long-term effects of high atomic number, high energy (HZE) ion exposure on various organ systems and the immune sys

Externí odkaz: https://doaj.org/article/9770fa35f74646788c44d77efba6413a

Zobrazit plný text záznamu

Akademický článek

Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity

Autor: Jason D. Domogauer, Sonia M. de Toledo, Roger W. Howell, Edouard I. Azzam

Publikováno v: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-17 (2021)

Abstract Background Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhan

Externí odkaz: https://doaj.org/article/46869f0a4eb74fd08ac61074d934fc7e

Zobrazit plný text záznamu

Akademický článek

Concomitant quantification of targeted drug delivery and biological response in individual cells

Autor: Massimo Pinto, Roger W. Howell

Publikováno v: BioTechniques, Vol 43, Iss 1, Pp 64-71 (2007)

Targeted therapies result in heterogeneous drug delivery, often with highly variable drug uptake in the targeted cells and significant numbers of cells that are essentially untargeted. However, both the variably targeted cells and neighboring bystand

Externí odkaz: https://doaj.org/article/046bc942bfc64fe7ba66d29f7a74cb6d

Zobrazit plný text záznamu

Predicting response of micrometastases with MIRDcell V3: proof of principle with 225Ac-DOTA encapsulating liposomes that produce different activity distributions in tumor spheroids

Autor: Sumudu Katugampola, Jianchao Wang, Aprameya Prasad, Stavroula Sofou, Roger W. Howell

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 49:3989-3999

The spatial distribution of radiopharmaceuticals within multicellular clusters is known to have a significant effect on their biological response. Most therapeutic radiopharmaceuticals distribute nonuniformly in tissues which makes predicting respons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c57a893bb955a1d0fd61f5d9f22436
https://doi.org/10.1007/s00259-022-05878-7

Zobrazit plný text záznamu

Plný text ve formátu HTML

Data from Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow

Autor: Roger W. Howell, Edouard I. Azzam, Didier Rajon, Tom Bäck, J. Christopher Fritton, Calvin N. Leung, Brian S. Canter

Radiation-induced bystander effects have been implicated in contributing to the growth delay of disseminated tumor cells (DTC) caused by 223RaCl2, an alpha particle–emitting radiopharmaceutical. To understand how 223RaCl2 affects the growth, we hav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214783cb48d66eee27a2a2deda23b471
https://doi.org/10.1158/1541-7786.c.6544964.v1

Zobrazit plný text záznamu

Supplementary Data, Supplementary Figures 1 and 2, Supplementary Tables 1-6 from Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow

Autor: Roger W. Howell, Edouard I. Azzam, Didier Rajon, Tom Bäck, J. Christopher Fritton, Calvin N. Leung, Brian S. Canter

Supplementary Figure S1. Estimating regional tumor volume within transverse sections. Table S1. Tumor dimensions of the human breast cancer cells inoculated into tibiae Supplementary Figure S2. Clonogenic survival of alpha-particle irradiated MDA-MB-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5c2f919e5cfced23c09e56494418b7
https://doi.org/10.1158/1541-7786.22525946.v1

Zobrazit plný text záznamu

Modeling bystander effects that cause growth delay of breast cancer xenografts in bone marrow of mice treated with radium-223

Autor: Tom Bäck, Calvin N. Leung, Didier A. Rajon, J. Christopher Fritton, Roger W. Howell, Edouard I. Azzam, Brian S. Canter

Publikováno v: Int J Radiat Biol

RATIONALE. The role of radiation-induced bystander effects in cancer therapy with alpha-particle emitting radiopharmaceuticals remains unclear. With renewed interest in using alpha-particle emitters to sterilize disseminated tumor cells, micrometasta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8120836ba7d934673aeec544a25d2f51
https://doi.org/10.1080/09553002.2021.1951392

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání