Zobrazeno 1 - 10 of 137 pro vyhledávání: '"Roger W. Howell"'
1
Akademický článek
Late effects of heavy-ion space radiation on splenocyte subpopulations and NK cytotoxic function
Autor: Calvin N. Leung, Donna M. Howell, Sonia M. De Toledo, Edouard I. Azzam, Roger W. Howell
Publikováno v: Frontiers in Astronomy and Space Sciences, Vol 9 (2022)
Introduction: With current goals of increased space exploration and travel to Mars, there has been great interest in understanding the long-term effects of high atomic number, high energy (HZE) ion exposure on various organ systems and the immune sys
Externí odkaz: https://doaj.org/article/9770fa35f74646788c44d77efba6413a
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2
Akademický článek
Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity
Autor: Jason D. Domogauer, Sonia M. de Toledo, Roger W. Howell, Edouard I. Azzam
Publikováno v: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhan
Externí odkaz: https://doaj.org/article/46869f0a4eb74fd08ac61074d934fc7e
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3
Predicting response of micrometastases with MIRDcell V3: proof of principle with 225Ac-DOTA encapsulating liposomes that produce different activity distributions in tumor spheroids
Autor: Sumudu Katugampola, Jianchao Wang, Aprameya Prasad, Stavroula Sofou, Roger W. Howell
Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 49:3989-3999
The spatial distribution of radiopharmaceuticals within multicellular clusters is known to have a significant effect on their biological response. Most therapeutic radiopharmaceuticals distribute nonuniformly in tissues which makes predicting respons
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c57a893bb955a1d0fd61f5d9f22436
https://doi.org/10.1007/s00259-022-05878-7
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4
Data from Radium-223–Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow
Autor: Roger W. Howell, Edouard I. Azzam, Didier Rajon, Tom Bäck, J. Christopher Fritton, Calvin N. Leung, Brian S. Canter
Radiation-induced bystander effects have been implicated in contributing to the growth delay of disseminated tumor cells (DTC) caused by 223RaCl2, an alpha particle–emitting radiopharmaceutical. To understand how 223RaCl2 affects the growth, we hav
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214783cb48d66eee27a2a2deda23b471
https://doi.org/10.1158/1541-7786.c.6544964.v1
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9
Modeling bystander effects that cause growth delay of breast cancer xenografts in bone marrow of mice treated with radium-223
Autor: Tom Bäck, Calvin N. Leung, Didier A. Rajon, J. Christopher Fritton, Roger W. Howell, Edouard I. Azzam, Brian S. Canter
Publikováno v: Int J Radiat Biol
RATIONALE. The role of radiation-induced bystander effects in cancer therapy with alpha-particle emitting radiopharmaceuticals remains unclear. With renewed interest in using alpha-particle emitters to sterilize disseminated tumor cells, micrometasta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8120836ba7d934673aeec544a25d2f51
https://doi.org/10.1080/09553002.2021.1951392
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10
Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity
Autor: Sonia M. de Toledo, Roger W. Howell, Edouard I. Azzam, Jason D. Domogauer
Publikováno v: Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-17 (2021)
Cell Communication and Signaling : CCS
BackgroundCancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We tested the hypothesis that CAFs develop unique characteristics that enhance their r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31efe4cac8acb3d886e2ab5a8f0526a1
https://doaj.org/article/46869f0a4eb74fd08ac61074d934fc7e
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