Synthetic multivalent antifungal peptides effective against fungi.

Autor: Rajamani Lakshminarayanan, Shouping Liu, Jianguo Li, Muruganantham Nandhakumar, Thet Tun Aung, Eunice Goh, Jamie Ya Ting Chang, Padhmanaban Saraswathi, Charles Tang, Siti Radiah Binte Safie, Lim Yih Lin, Howard Riezman, Zhou Lei, Chandra S Verma, Roger W Beuerman

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e87730 (2014)

Taking advantage of the cluster effect observed in multivalent peptides, this work describes antifungal activity and possible mechanism of action of tetravalent peptide (B4010) which carries 4 copies of the sequence RGRKVVRR through a branched lysine

Externí odkaz: https://doaj.org/article/3ac6c677bc2d44b58f3161d4fd26c57e

Transglutaminases (TGs) in ocular and periocular tissues: effect of muscarinic agents on TGs in scleral fibroblasts.

Autor: V A Barathi, Sung R Weon, Queenie S W Tan, Kwan J Lin, Louis Tong, Roger W Beuerman

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18326 (2011)

OBJECTIVE: To investigate the expression of transglutaminases (TGs) in the ocular surface, the eyelid margin and associated glands and to determine effect of muscarinic agents on TGs in scleral fibroblasts (SF). MATERIALS AND METHODS: Primary SFs cul

Externí odkaz: https://doaj.org/article/7006a70930c5483aaca3bdc2f813c94b

Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa

Autor: Joey Kuok Hoong Yam, Thet Tun Aung, Song Lin Chua, Yingying Cheng, Gurjeet Singh Kohli, Jianuan Zhou, Florentin Constancias, Yang Liu, Zhao Cai, May Margarette Santillan Salido, Daniela I. Drautz-Moses, Scott A. Rice, Stephan Christoph Schuster, Zhao Zhi Boo, Bin Wu, Staffan Kjelleberg, Tim Tolker-Nielsen, Rajamani Lakshminarayanan, Roger W. Beuerman, Liang Yang, Michael Givskov

Publikováno v: Infection and immunity, 90 (8)
Yam, J K H, Aung, T T, Chua, S L, Cheng, Y, Kohli, G S, Zhou, J, Constancias, F, Liu, Y, Cai, Z, Salido, M M S, Drautz-Moses, D I, Rice, S A, Schuster, S C, Boo, Z Z, Wu, B, Kjelleberg, S, Tolker-Nielsen, T, Lakshminarayanan, R, Beuerman, R W, Yang, L & Givskov, M 2022, ' Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa ', Infection and Immunity, vol. 90, no. 8 . https://doi.org/10.1128/iai.00061-22

Pseudomonas aeruginosa is generally believed to establish biofilm-associated infections under the regulation of the secondary messenger c-di-GMP. To evaluate P. aeruginosa biofilm physiology during ocular infections, comparative transcriptomic analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faabfddccbc986ff3c6cef4e563402a5
https://hdl.handle.net/10453/164130

Dissecting the Molecular Mechanism of Colistin Resistance in mcr-1 Bacteria

Autor: Chandra S. Verma, Roger W. Beuerman, Jianguo Li

Publikováno v: Journal of Chemical Information and Modeling. 60:4975-4984

Colistin or polymyxin B is the last resort antibiotic to treat infections of multidrug-resistant Gram-negative bacteria by disrupting their outer membranes. The recent emergence of Gram-negative bacteria that demonstrate colistin resistance, particul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a373565f30099bde267a86967d6a3d47
https://doi.org/10.1021/acs.jcim.0c01051

Rabbit Fungal Keratitis Model of Fusarium solani Tested Against Three Commercially Available Antifungal Drugs

Autor: Roger W. Beuerman, Myoe Naing Lynn, Wei Hong Jeff Chor, Donald T.H. Tan, Thet Tun Aung, Anita Sook Yee Chan

Publikováno v: Eye & Contact Lens

Objectives The purpose of this study was to develop a reproducible preclinical Fusarium solani keratitis model, which would allow comparative testing of currently available antifungals (NATACYN [Alcon, Fort Worth, TX], voriconazole 1%, and amphoteric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46977e472ccf54ef6522dda73166c495
https://doi.org/10.1097/icl.0000000000000689