Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Roger Ulrich"'
Autor:
Eric E Schadt, Cliona Molony, Eugene Chudin, Ke Hao, Xia Yang, Pek Y Lum, Andrew Kasarskis, Bin Zhang, Susanna Wang, Christine Suver, Jun Zhu, Joshua Millstein, Solveig Sieberts, John Lamb, Debraj GuhaThakurta, Jonathan Derry, John D Storey, Iliana Avila-Campillo, Mark J Kruger, Jason M Johnson, Carol A Rohl, Atila van Nas, Margarete Mehrabian, Thomas A Drake, Aldons J Lusis, Ryan C Smith, F Peter Guengerich, Stephen C Strom, Erin Schuetz, Thomas H Rushmore, Roger Ulrich
Publikováno v:
PLoS Biology, Vol 6, Iss 5, p e107 (2008)
Genetic variants that are associated with common human diseases do not lead directly to disease, but instead act on intermediate, molecular phenotypes that in turn induce changes in higher-order disease traits. Therefore, identifying the molecular ph
Externí odkaz:
https://doaj.org/article/690823c1095b471bb00d96bfa2f8780e
Autor:
Sarah E.M. Herman, Adrian Wiestner, Brian J. Lannutti, Roger Ulrich, Raquel Izumi, Nicholas Chiorazzi, Shih-Shih Chen, Todd Covey, Fanny Krantz, Eman L. Dadashian, Helena I. Mora-Jensen, Carsten U. Niemann
Supplementary methods and figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9e963db2def1ccd6770542861e7c6d
https://doi.org/10.1158/1078-0432.22466763
https://doi.org/10.1158/1078-0432.22466763
Autor:
Jennifer A. Woyach, Adrian Wiestner, Brian J. Lannutti, Amy J. Johnson, Roger Ulrich, Allard Kaptein, Raquel Izumi, John C. Byrd, Todd Covey, Dolors Colomer, Bonnie K. Harrington, Fabienne McClanahan, Lisa L. Smith, Rose Mantel, Fanny Krantz, Michael Gulrajani, Helena Mora-Jensen, Carsten U. Niemann, Arnau Montraveta, Sarah E.M. Herman
Purpose: Acalabrutinib (ACP-196) is a novel, potent, and highly selective Bruton tyrosine kinase (BTK) inhibitor, which binds covalently to Cys481 in the ATP-binding pocket of BTK. We sought to evaluate the antitumor effects of acalabrutinib treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3ca1183f3e1691c0fae26104477a98
https://doi.org/10.1158/1078-0432.c.6525228.v1
https://doi.org/10.1158/1078-0432.c.6525228.v1
Autor:
Jennifer A. Woyach, Adrian Wiestner, Brian J. Lannutti, Amy J. Johnson, Roger Ulrich, Allard Kaptein, Raquel Izumi, John C. Byrd, Todd Covey, Dolors Colomer, Bonnie K. Harrington, Fabienne McClanahan, Lisa L. Smith, Rose Mantel, Fanny Krantz, Michael Gulrajani, Helena Mora-Jensen, Carsten U. Niemann, Arnau Montraveta, Sarah E.M. Herman
Supplementary Table S1. Kinase selectivity of acalabrutinib as assessed by DiscoveRX KinomeScan screening.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cd29d20b722cbec12775285af50743
https://doi.org/10.1158/1078-0432.22462842
https://doi.org/10.1158/1078-0432.22462842
Autor:
Sarah E.M. Herman, Adrian Wiestner, Brian J. Lannutti, Roger Ulrich, Raquel Izumi, Nicholas Chiorazzi, Shih-Shih Chen, Todd Covey, Fanny Krantz, Eman L. Dadashian, Helena I. Mora-Jensen, Carsten U. Niemann
Supplementary Figures 1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d35da5b1fd2d246302b9fc076dfa015
https://doi.org/10.1158/1078-0432.22466766
https://doi.org/10.1158/1078-0432.22466766
Autor:
Sarah E.M. Herman, Adrian Wiestner, Brian J. Lannutti, Roger Ulrich, Raquel Izumi, Nicholas Chiorazzi, Shih-Shih Chen, Todd Covey, Fanny Krantz, Eman L. Dadashian, Helena I. Mora-Jensen, Carsten U. Niemann
Purpose: Targeting the B-cell receptor (BCR) pathway with inhibitors of Bruton tyrosine kinase (BTK) and PI3Kδ is highly effective for the treatment of chronic lymphocytic leukemia (CLL). However, deep remissions are uncommon, and drug resistance wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0fddd823adb7de6d26575573dd0c29
https://doi.org/10.1158/1078-0432.c.6526416.v1
https://doi.org/10.1158/1078-0432.c.6526416.v1
Autor:
Jennifer A. Woyach, Adrian Wiestner, Brian J. Lannutti, Amy J. Johnson, Roger Ulrich, Allard Kaptein, Raquel Izumi, John C. Byrd, Todd Covey, Dolors Colomer, Bonnie K. Harrington, Fabienne McClanahan, Lisa L. Smith, Rose Mantel, Fanny Krantz, Michael Gulrajani, Helena Mora-Jensen, Carsten U. Niemann, Arnau Montraveta, Sarah E.M. Herman
Supplementary Figure S5: Acalabrutinib demonstrates similar changes in proliferation and tumor burden in the CLL xenograft mouse model as ibrutinib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09c6b24397ba4d6b61ecbea462928663
https://doi.org/10.1158/1078-0432.22462839
https://doi.org/10.1158/1078-0432.22462839
Autor:
Jennifer A. Woyach, Adrian Wiestner, Brian J. Lannutti, Amy J. Johnson, Roger Ulrich, Allard Kaptein, Raquel Izumi, John C. Byrd, Todd Covey, Dolors Colomer, Bonnie K. Harrington, Fabienne McClanahan, Lisa L. Smith, Rose Mantel, Fanny Krantz, Michael Gulrajani, Helena Mora-Jensen, Carsten U. Niemann, Arnau Montraveta, Sarah E.M. Herman
Supplementary Figure S1: Acalabrutinib is a more potent BCR-inhibitor than ibrutinib in vivo at 1mg/kg and 3mg/kg. Supplementary Figure S2: In vivo gating strategy for murine cells. Supplementary Figure S3: In vivo acalabrutinib treatment inhibits BC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e9dec56789480c721bd888084a7d11
https://doi.org/10.1158/1078-0432.22462836.v1
https://doi.org/10.1158/1078-0432.22462836.v1
Autor:
David Stauffer, Anant Singh, Giuseppe Surace, John D. Keay, Dario Carnelli, Armin Tajalli, Anton Tschank, Kiarash Gharibdoust, Roger Ulrich, Davide Gorret, Omid Talebi Amiri, John L. Phillips, Yohann Mogentale, Ali Hormati, Klaas L. Hofstra, Amin Shokrollahi, Christoph Walter, Christopher Hall, Victor Perrin, Ahmed Hassanin, Richard Simpson, Andrew Kevin John Stewart, Sumathi Raparthy, Amit Gupta, Brian Holden, Mani Bastani Parizi, Chen Cao, Emanuele Truffa
Publikováno v:
IEEE Journal of Solid-State Circuits. 55:1108-1123
An energy-efficient (1.02 pJ/b) and high-speed (20.83 Gb/s/wire, 417 Gb/s/mm) link for ultra-short reach (USR) applications (up to 6-dB channel loss at the Nyquist frequency of 12.5 GHz) is presented. Correlated non-return to zero (CNRZ) signaling wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bed0ebcd1b07200948f8aadadea77d7
https://doi.org/10.1109/jssc.2019.2962655
https://doi.org/10.1109/jssc.2019.2962655
Autor:
Nolan Lassaline, Daniel Chelladurai, Manuel Kohli, Roger Ulrich, Yannik Glauser, Daniel Petter, Juerg Leuthold, David J. Norris
We incorporate Fourier surfaces into silicon waveguides with vertical tapers for next generation photonic grating couplers. By combining thermal scanning-probe lithography and reactive-ion etching, we generate gratings with smoothly apodized depth pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccaa3bdde9147a77d6ec1267f0508664