Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Roger Tremblay"'
Autor:
Jagdeep K. Sandhu, Mossa Gardaneh, Rafal Iwasiow, Patricia Lanthier, Sandhya Gangaraju, Maria Ribecco-Lutkiewicz, Roger Tremblay, Kazutoshi Kiuchi, Marianna Sikorska
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 405-414 (2009)
In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astroc
Externí odkaz:
https://doaj.org/article/b6944e2dc2ff4221b180093aa47e29ba
Autor:
Anna Jezierski, Kerry Rennie, Roger Tremblay, Bogdan Zurakowski, Andreé Gruslin, Marianna Sikorska, Mahmud Bani-Yaghoub
Publikováno v:
Stem Cells International, Vol 2012 (2012)
The usage of stem cells is a promising strategy for the repair of damaged tissue in the injured brain. Recently, amniotic fluid (AF) cells have received a lot of attention as an alternative source of stem cells for cell-based therapies. However, the
Externí odkaz:
https://doaj.org/article/7d89b45a69034a569fe4e88fad4a30f1
Autor:
Trevor Atkinson, Hui Li, Jian Wang, Roger Tremblay, Alastair M. Buchan, Balu Chakravarthy, Jon P. Durkin, Fuhu Wang
Changes in protein kinase C (PKC) were compared in primary cortical neurons exposed to glutamate and in the CA-1 hippocampal region of rats subjected to transient cerebral ischaemia. After a 15-min exposure of cortical neurons to excitotoxic levels o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c755796c5eef171f66c72a1d41a79e58
https://doi.org/10.1016/s0898-6568(97)00131-9
https://doi.org/10.1016/s0898-6568(97)00131-9
Autor:
Bogdan Zurakowski, Marianna Sikorska, Bernard Massie, Maria Ribecco-Lutkiewicz, David W. Chitty, Julie Haukenfrers, Mahmud Bani-Yaghoub, Roger Tremblay
Publikováno v:
Journal of Neuroscience Methods. 205:17-27
Bone morphogenetic protein 7 (BMP7), a member of the transforming growth factor β (TGF-β) superfamily, plays important roles in the development of various tissues and organs in mouse and human. In particular, BMP7 is critical for the formation of t
Autor:
Anna Jezierski, Andrée Gruslin, Dao Ly, Mahmud Bani-Yaghoub, Marianna Sikorska, Roger Tremblay, Brandon Smith, Cathie Smith
Publikováno v:
Stem Cell Reviews and Reports. 6:677-684
The NOTCH signaling pathway plays important roles in stem cell maintenance, cell-fate determination and differentiation during development. Following ligand binding, the cleaved NOTCH intracellular domain (NICD) interacts directly with the recombinan
Autor:
Roger Tremblay, Jagdeep K. Sandhu, Patricia Lanthier, Marianna Sikorska, Mahmud Bani-Yaghoub, Maria Ribecco-Lutkiewicz
Publikováno v:
Journal of Neuroscience Methods. 186:60-67
Neuro 2A (N2a) is a mouse neural crest-derived cell line that has been extensively used to study neuronal differentiation, axonal growth and signaling pathways. A convenient characteristic of these cells is their ability to differentiate into neurons
Autor:
Sandhya Gangaraju, Mossa Gardaneh, Jagdeep K. Sandhu, Rafal Iwasiow, Marianna Sikorska, Maria Ribecco-Lutkiewicz, Kazutoshi Kiuchi, Roger Tremblay, Patricia Lanthier
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 405-414 (2009)
In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astroc
Autor:
Marianna Sikorska, Robert Monette, Raluca Voicu, Christophe Py, Mahmud Bani-Yaghoub, Roger Tremblay, Geoff Mealing, Karim Faid
Publikováno v:
Biotechnology and Bioengineering. 92:336-345
Neural networks are formed by accurate connectivity of neurons and glial cells in the brain. These networks employ a three-dimensional bio-surface that both assigns precise coordinates to cells during development and facilitates their connectivity an
Autor:
Geoffrey A.R. Mealing, Marsha A. Black, James F. Whitfield, Jon P. Durkin, Roger Tremblay, Paul Morley
Publikováno v:
Journal of Neurochemistry. 66:989-995
The neuroprotective actions of remacemide and its anticonvulsant metabolite 1,2-diphenyl-2-propylamine monohydrochloride (desglycinylremacemide; DGR) a low-affinity NMDA receptor antagonist, were investigated using primary rat cortical neuronal cultu
Autor:
Paul Morley, Christine L. Murray, Nicole B. Laferriere, David L. Brown, Jon P. Durkin, Robert Monette, Roger Tremblay
Publikováno v:
Neurological Research. 21:524-528
The low-affinity use-dependent N-methyl-D-aspartate (NMDA) receptor antagonist AR-R15896AR is neuroprotective in primary rat cortical cultures exposed to toxic concentrations of NMDA and reduces the magnitude of NMDA-triggered increases in [Ca2+]i. H