Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Roger Sleigh"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The PIM1 serine/threonine protein kinase mediates growth factor and survival signalling, and cooperates potently with c-MYC during tumorigenesis. PIM1 is overexpressed in many human cancers and is a promising target for drug development. PIM
Externí odkaz:
https://doaj.org/article/e921f6e7df054849bf32d4abc8984c40
Autor:
Kristin Uth, Roger Sleigh
Publikováno v:
Biotechnology, Biotechnological Equipment
Many physiological processes occur in a rhythmic fashion, consistent with a 24-h cycle. The central timing of the day/night rhythm is set by a master clock, located in the suprachiasmatic nucleus (a tiny region in the hypothalamus), but peripheral cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6261a89b4f8592638b21841ca162c9
http://europepmc.org/articles/PMC4434034
http://europepmc.org/articles/PMC4434034
Autor:
Roger Sleigh, Kristin Uth
Publikováno v:
Biotechnology & Biotechnological Equipment. 28:379-386
The uneventful progression through the cell cycle is closely associated with the rhythm set by the circadian clock machinery, with the S-phase of the cell cycle typically occurring at night. Presence of unrepaired DNA damage may reset the phase of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db37d2e042fc242ed9e4ddd5224fe0c3
https://doi.org/10.1080/13102818.2014.925298
https://doi.org/10.1080/13102818.2014.925298
Publikováno v:
Virology
The HIV-1 Vpr protein is a virion-associated protein which has been shown to facilitate infection of nondividing macrophages and additionally to alter cell cycle and proliferation status of the infected host cell. HIV-1 Vpr also was recently shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617489f94369d49a2a6cb452f068042f
Publikováno v:
Scopus-Elsevier
Evasion of the checks and balances that govern the human cell division cycle lies at the heart of all proliferative diseases. Because of the astonishing variety of ways that cancer cells manage to achieve growth advantages over normally proliferating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52472a9a87d706474fb128407f8557c4
http://www.scopus.com/inward/record.url?eid=2-s2.0-11344264871&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-11344264871&partnerID=MN8TOARS
Autor:
GAMSA, MARK1
Publikováno v:
Journal of World History. Sep2011, Vol. 22 Issue 3, p553-575. 23p.
Autor:
Todd Gray
112 tax lists for Devon for the period from 1500 to 1650.Tax lists are a key means of understanding parish life in the 1500s and early 1600s. This collection of 112 records for towns and villages such as Crediton and Dartmouth is published here for t
Autor:
Jo Marchant
A Best Book of 2020 NPRA Best Book of 2020 The EconomistA Top Ten Best Science Book of 2020 Smithsonian A Best Science & Technology Book of 2020 Library JournalA Must-Read Book to Escape the Chaos of 2020 NewsweekStarred review Booklist Starred
Autor:
Jo Marchant
For most of human history, we have had a close relationship with the stars. Once they shaped our religious beliefs, power structures, scientific advances and even our biology. But over the last few centuries we have separated ourselves from the unive
Autor:
Graham Drucker
This is the biography of one of the Royal Navys legendary pilots. BF or Daddy as he was known, started his career at Dartmouth and then spent his early seagoing years in Hong Kong, Nagasaki and Hiroshima. His wartime experiences as a Fleet Air pilot