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of 3
pro vyhledávání: '"Roger Schilling"'
Autor:
Heidi Rath Hope, Deborah Heuvelman, Kevin Duffin, Christine Smith, Jeffery Zablocki, Roger Schilling, Shridhar Hegde, Len Lee, Bryan Witherbee, Mark Baganoff, Can Bruce, Alan R. Tall, Elaine Krul, Kevin Glenn, Daniel T. Connolly
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 10, Pp 1604-1614 (2000)
SC-71952, a substituted analog of dithiobisnicotinic acid dimethyl ester, was identified as a potent inhibitor of cholesteryl ester transfer protein (CETP). When tested in an in vitro assay, the concentration of SC-71952 required for half-maximal inh
Externí odkaz:
https://doaj.org/article/cc5033ac3088478fbe63f90dab676d71
Autor:
Digamber Rane, Jennifer E. Golden, Richa Arya, Zachary Maben, Roger Schilling, Irini Evnouchidou, Akbar Ali, Tina T Nguyen, Marc Hickey, Samantha Bender, Efstratios Stratikos, Lawrence J. Stern, W. Frank An, Shailesh Metkar
Publikováno v:
J Med Chem
ERAP1 is an endoplasmic reticulum-resident zinc aminopeptidase that plays an important role in the immune system by trimming peptides for loading onto major histocompatibility complex (MHC-I) proteins. Here we report discovery of the first inhibitors
Autor:
John E. Dominy, Michelle Palmer, Mark P. Jedrychowski, Amy K. Rines, Joao Paulo Camporez, Jaemin Lee, Theodore M. Kamenecka, Marc Hickey, Hua Lin, Stuart L. Schreiber, Clint D.J. Tavares, Pere Puigserver, Melissa Bennion, Roger Schilling, Umut Ozcan, Joshua A. Bittker, Gerald I. Shulman, Rachel J. Perry, Kfir Sharabi, Steve P. Gygi, Partha P. Nag, José Carlos Rodríguez Pérez, Patrick R. Griffin
Publikováno v:
Cell. 169:148-160.e15
Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeti