Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Roger S. Goody"'
Autor:
Amrita Rai, Anurag K. Singh, Nathalie Bleimling, Guido Posern, Ingrid R. Vetter, Roger S. Goody
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Rep15 is an effector that interacts with the GTPase Rab15. Here, the authors show that Rep15 also interacts with Rab3 paralogs and Rab34, present crystal structures of Rep15:Rab complexes and find that Rep15 depletion in glioblastoma cells decreases
Externí odkaz:
https://doaj.org/article/bc3756c4bd714733bf975e62ee0d8c3f
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
EHBP1 is an adaptor protein that regulates vesicular trafficking and links endosomes to the actin cytoskeleton. Here, authors show that both termini of EHBP1 have membrane targeting potential and that in the absence of its binding partner Rab8, the b
Externí odkaz:
https://doaj.org/article/07b071be9df341b19ce4e9192524659d
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Simple reversible competitive inhibition of nucleotide binding of GTP to Ras family GTPases has long been recognized as an unlikely approach to manipulating the activity of such proteins for experimental or therapeutic purposes. This is due
Externí odkaz:
https://doaj.org/article/2905962a45d8475ebe1fcab659106648
Autor:
Guowei Yin, Tomas Lopes da Fonseca, Sibylle E. Eisbach, Ane Martín Anduaga, Carlo Breda, Maria L. Orcellet, Éva M. Szegő, Patricia Guerreiro, Diana F. Lázaro, Gerhard H. Braus, Claudio O. Fernandez, Christian Griesinger, Stefan Becker, Roger S. Goody, Aymelt Itzen, Flaviano Giorgini, Tiago F. Outeiro, Markus Zweckstetter
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 149-161 (2014)
Alpha-synuclein (αS) misfolding is associated with Parkinson's disease (PD) but little is known about the mechanisms underlying αS toxicity. Increasing evidence suggests that defects in membrane transport play an important role in neuronal dysfunct
Externí odkaz:
https://doaj.org/article/7480409adf064c3290f3436c07a5b54c
Autor:
Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S Goody, Matthias P Müller, Daniel Rauh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9fef2d901ca844d77790e3ee8bb9e4e
https://doi.org/10.7554/elife.82184.sa2
https://doi.org/10.7554/elife.82184.sa2
Autor:
Lisa Goebel, Tonia Kirschner, Sandra Koska, Amrita Rai, Petra Janning, Stefano Maffini, Helge Vatheuer, Paul Czodrowski, Roger S. Goody, Matthias P. Müller, Daniel Rauh
Mutations within Ras proteins represent major drivers in human cancer. In this study, we report the structure-based design, synthesis, as well as biochemical and cellular evaluation of nucleotide-based covalent inhibitors for KRasG13C, an important o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8059c0af079cd564489957a2783e2d4
https://doi.org/10.1101/2022.07.25.501348
https://doi.org/10.1101/2022.07.25.501348
Autor:
Mohammad Akbarzadeh, Jana Flegel, Sumersing Patil, Erchang Shang, Rishikesh Narayan, Marcel Buchholzer, Neda S. Kazemein Jasemi, Michael Grigalunas, Adrian Krzyzanowski, Daniel Abegg, Anton Shuster, Marco Potowski, Hacer Karatas, George Karageorgis, Niloufar Mosaddeghzadeh, Mia‐Lisa Zischinsky, Christian Merten, Christopher Golz, Lucas Brieger, Carsten Strohmann, Andrey P. Antonchick, Petra Janning, Alexander Adibekian, Roger S. Goody, Mohammad Reza Ahmadian, Slava Ziegler, Herbert Waldmann
Publikováno v:
Angewandte Chemie International Edition. 61
For the discovery of novel chemical matter generally endowed with bioactivity, strategies may be particularly efficient that combine previous insight about biological relevance, e.g., natural product (NP) structure, with methods that enable efficient
Autor:
Amrita Rai, Anastasia Oprisko, Jeremy Campos, Yangxue Fu, Timon Friese, Aymelt Itzen, Roger S Goody, Emerich Mihai Gazdag, Matthias P Müller
Publikováno v:
eLife, Vol 5 (2016)
In their active GTP-bound form, Rab proteins interact with proteins termed effector molecules. In this study, we have thoroughly characterized a Rab effector domain that is present in proteins of the Mical and EHBP families, both known to act in endo
Externí odkaz:
https://doaj.org/article/88f6649ae09b46f082bad04cae9c62a5
Autor:
Amrita Rai, Anurag K. Singh, Nathalie Bleimling, Guido Posern, Ingrid R. Vetter, Roger S. Goody
Publikováno v:
Nature communications. 13(1)
In their GTP-bound (active) form, Rab proteins interact with effector proteins that control downstream signaling. One such Rab15 effector is Rep15, which is known to have a role in receptor recycling from the endocytic recycling compartment but other
Autor:
Roger S. Goody
Publikováno v:
Quantitative Analysis of Biospecific Interactions ISBN: 9781315824994
GTP-binding proteins constitute a class of proteins which are involved in signal transduction and regulation of many processes in the cell. They are, in general, GTPases. The basis of their action is that they have different properties with respect t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635df50c43c8dd803c33a3bb64fe9f0e
https://doi.org/10.4324/9781315824994-8
https://doi.org/10.4324/9781315824994-8