Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Roger S, Chung"'
Autor:
Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitati
Externí odkaz:
https://doaj.org/article/4c4d2aa5f2d24e1cbc0429058653faa3
Autor:
Audrey M. G. Ragagnin, Vinod Sundaramoorthy, Fabiha Farzana, Shashi Gautam, Sayanthooran Saravanabavan, Zeinab Takalloo, Prachi Mehta, Dzung Do-Ha, Sonam Parakh, Sina Shadfar, Julie Hunter, Marta Vidal, Cyril J. Jagaraj, Mariana Brocardo, Anna Konopka, Shu Yang, Stephanie L. Rayner, Kelly L. Williams, Ian P. Blair, Roger S. Chung, Albert Lee, Lezanne Ooi, Julie D. Atkin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative condition that is part of the same disease spectrum as frontotemporal dementia (FTD). Mutations in the CCNF gene, encoding cyclin F, are present in both sporadi
Externí odkaz:
https://doaj.org/article/1f9777d0e41944dcbe2282cfb312d1fe
Autor:
Andrés Vidal-Itriago, Rowan A. W. Radford, Jason A. Aramideh, Cindy Maurel, Natalie M. Scherer, Emily K. Don, Albert Lee, Roger S. Chung, Manuel B. Graeber, Marco Morsch
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia are mononuclear phagocytes of mesodermal origin that migrate to the central nervous system (CNS) during the early stages of embryonic development. After colonizing the CNS, they proliferate and remain able to self-renew throughout life, mai
Externí odkaz:
https://doaj.org/article/6c34917349694477bf1a9b965618603b
Autor:
Maxinne Watchon, Luan Luu, Katherine J. Robinson, Kristy C. Yuan, Alana De Luca, Hannah J. Suddull, Madelaine C. Tym, Gilles J. Guillemin, Nicholas J. Cole, Garth A. Nicholson, Roger S. Chung, Albert Lee, Angela S. Laird
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-16 (2021)
Abstract Machado-Joseph disease (MJD, also known as spinocerebellar ataxia type 3) is a fatal neurodegenerative disease that impairs control and coordination of movement. Here we tested whether treatment with the histone deacetylase inhibitor sodium
Externí odkaz:
https://doaj.org/article/c4c31cfe9850482096f4f4f803675be2
Publikováno v:
Neurobiology of Disease, Vol 166, Iss , Pp 105653- (2022)
Investigations into the pathogenetic mechanisms underlying amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have provided significant insight into the disease. At the cellular level, ALS and FTD are classified as proteinopathies,
Externí odkaz:
https://doaj.org/article/2308bff4aca04d7ab283a63ee4159659
Autor:
Flora Cheng, Alana De Luca, Alison L. Hogan, Stephanie L. Rayner, Jennilee M. Davidson, Maxinne Watchon, Claire H. Stevens, Sonia Sanz Muñoz, Lezanne Ooi, Justin J. Yerbury, Emily K. Don, Jennifer A. Fifita, Maria D. Villalva, Hannah Suddull, Tyler R. Chapman, Thomas J. Hedl, Adam K. Walker, Shu Yang, Marco Morsch, Bingyang Shi, Ian P. Blair, Angela S. Laird, Roger S. Chung, Albert Lee
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The past decade has seen a rapid acceleration in the discovery of new genetic causes of ALS, with more than 20 putative ALS-causing genes now cited. These genes encode proteins that cover a diverse range of molecular functions, including free radical
Externí odkaz:
https://doaj.org/article/6d9d5478214e4a43b5c90d1b2ff9a16b
Autor:
Isabel Formella, Adam J. Svahn, Rowan A.W. Radford, Emily K. Don, Nicholas J. Cole, Alison Hogan, Albert Lee, Roger S. Chung, Marco Morsch
Publikováno v:
Redox Biology, Vol 19, Iss , Pp 226-234 (2018)
Generation of reactive oxygen species (ROS) has been shown to be important for many physiological processes, ranging from cell differentiation to apoptosis. With the development of the genetically encoded photosensitiser KillerRed (KR) it is now poss
Externí odkaz:
https://doaj.org/article/2d3e49ebf54b48fcaaf107a249f8872b
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-9 (2018)
Abstract Background The extracellular environment plays an important role in supporting the regeneration of axons after injury. Metallothionein-II (MTII) is a metal-binding protein known for its neuroprotective effect by directly stimulating the grow
Externí odkaz:
https://doaj.org/article/74b242c919bf4abebee6940f87312dad
Autor:
Jennilee M. Davidson, Sharlynn S. L. Wu, Stephanie L. Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M. Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L. Williams, Marco Morsch, Ian P. Blair, Antonio Di Ieva, Shu Yang, Roger S. Chung, Albert Lee
Publikováno v:
Molecular Neurobiology.
Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the cyclin F-E3 ligase complex SCFcyclinF known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e297e94dcdb8abb7f6625ed5a35097
https://doi.org/10.1007/s12035-023-03355-2
https://doi.org/10.1007/s12035-023-03355-2
Autor:
Natalie E Farrawell, Monique Bax, Luke McAlary, Jessie McKenna, Simon Maksour, Dzung Do-Ha, Stephanie L Rayner, Ian P Blair, Roger S Chung, Justin J Yerbury, Lezanne Ooi, Darren N Saunders
Publikováno v:
Human Molecular Genetics.
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are fatal neurodegenerative disorders that share pathological features, including the aberrant accumulation of ubiquitinated protein inclusions within motor neurons. Previously, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::250022409eefdc6a3a11d8a4478977ba
https://doi.org/10.1093/hmg/ddad063
https://doi.org/10.1093/hmg/ddad063