Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Roger Ryan Rothhaar"'
Autor:
Hao Sun, Michael O. Frederick, Roger Ryan Rothhaar, Amy C. DeBaillie, Brian Morgan Watson, Carlos Mateos, Leonard L. Winneroski, Carlos Jaramillo, Talbi Kaoudi, Matthew Johnson, Pablo Garcia-Losada, Srinivas Gangula, Peter J. Lindsay-Scott, Steven James Green, Dustin J. Mergott, Dajiang Jing, Marvin M. Hansen, José Eugenio de Diego, Juan A. Rincón, Kevin D. Seibert, Lei Zhang, Jiuyuan Li
Publikováno v:
Organic Process Research & Development. 24:306-314
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] ...
Publikováno v:
Organic Process Research & Development. 18:410-416
A combination of mechanism-guided experimentation and kinetic modeling was used to develop a mild, selective, and robust hydroxide-promoted process for conversion of a nitrile to an amide using a substoichiometric amount of aqueous sodium hydroxide i
Autor:
Edward W. Conder, Roger Ryan Rothhaar, Mark A. LaPack, Jared W. Fennell, Timothy M. Braden, R. Brian Scherer, Jeffrey Czarnik, Jeffrey Thomas Vicenzi, Mark D. Argentine, Jeffrey G. Wei, John Arnold Werner, Robert T. Roginski, Schmid Christopher Randall, Steven E. Dunlap
Publikováno v:
Organic Process Research & Development. 13:131-143
The impact of several new technologies on the development of a manufacturing process for LY518674 is described. Extensive use of process analytical technology (PAT) throughout development, both at laboratory and pilot-plant scale, enabled data-rich e
Autor:
Qing Shi, Christopher W. Doecke, Emily Jane Canada, John M. Zgombick, Timothy Ivo Richardson, Paul L. Ornstein, Michael J. Martinelli, Hansen M. Hsiung, Matt R. Reinhard, Jennifer L. Buckmaster, Chaoyu Xie, Roger Ryan Rothhaar, Larry Wayne Hertel, Zhipei Wu, Steve L. Kuklish, Karin Briner, Jikesh Arvind Shah, Saba Husain, Thomas P. O’Brien, Nick Honigschmidt, Macklin Brian Arnold, Ryan Thomas Backer, Jeffrey T. Mullaney, Matthew J. Fisher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2341-2346
A series of benzylic piperazines (e.g., 4 and 5) attached to an 'address element', the dipeptide H-D-Tic-D-p-Cl-Phe-OH, 3 has been identified as ligands for the melanocortin subtype-4 receptor (MC4R). We describe herein the structure-activity relatio
Autor:
Paul L. Ornstein, John M. Zgombick, Karin Briner, Saba Husain, Ryan Thomas Backer, Hansen M. Hsiung, Jeffrey T. Mullaney, Matthew J. Fisher, Roger Ryan Rothhaar, Thomas P. O’Brian
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4459-4462
Substitution of the aryl sulfonamide moiety contained in MC4 agonist 1 with bicyclic heterocycles and aminotetralines produced compounds with MC4 activity. The heterocycles represent alternative privileged structures to that contained in 1. Compounds