Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Roger Rush"'
Publikováno v:
Metabolites, Vol 2, Iss 3, Pp 596-613 (2012)
STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD). New clinical data in this article on the m
Externí odkaz:
https://doaj.org/article/0ea99961978841f1905a8d77cf6536eb
Autor:
Senthilkumar S. Karuppagounder, Hu Wang, Terence Kelly, Roger Rush, Richard Nguyen, Shivani Bisen, Yoko Yamashita, Nicholas Sloan, Brianna Dang, Alexander Sigmon, Hyeun Woo Lee, Shirley Marino Lee, Leslie Watkins, Erica Kim, Saurav Brahmachari, Manoj Kumar, Milton H. Werner, Ted M. Dawson, Valina L. Dawson
Publikováno v:
Science Translational Medicine. 15
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease of the central nervous system, with an estimated 5,000,000 cases worldwide. PD pathology is characterized by the accumulation of misfolded α-synuclein, which is though
Publikováno v:
Journal of Hepatology. 73:S864
Autor:
Roger Rush, Charlie Bu, Steven Smith, Gasparac Rahela, Marita Larsson Cohen, Kusum Sachdev Gupta, Hassan Rashidzadeh, Adel Moussa, Xin-Ru Pan-Zhou, Steven S. Good, Benjamin Alexander Mayes, Sanjeev Bhadresa
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 41:567-574
IDX184 is a phosphoramidate prodrug of 2′-methylguanosine-5′-monophosphate, developed to treat patients infected with hepatitis C virus. A mass balance study of radiolabeled IDX184 and pharmacokinetic studies of IDX184 in portal vein-cannulated m
Autor:
Anjali Kumar, Amy McDonough, Roger B. Clark, Lyn Libertine, Greg LaRosa, Roger Rush, Daniel Elbaum, Diana Lamppu
Publikováno v:
Journal of Medicinal Chemistry. 57:3966-3983
Herein we report the design, synthesis, and structure-activity relationships for a new class of α7 nicotinic acetylcholine receptor (nAChR) modulators based on the 2-((pyridin-3-yloxy)methyl)piperazine scaffold. The oxazolo[4,5-b]pyridine, (R)-18, a
Publikováno v:
Metabolites; Volume 2; Issue 3; Pages: 596-613
Metabolites, Vol 2, Iss 3, Pp 596-613 (2012)
Metabolites
Metabolites, Vol 2, Iss 3, Pp 596-613 (2012)
Metabolites
STX209 is an exploratory drug comprising the single, active R-enantiomer of baclofen which is in later stage clinical trials for the treatment of fragile x syndrome (FXS) and autism spectrum disorders (ASD). New clinical data in this article on the m
Autor:
Marita Larsson Cohen, Kusum Sachdev Gupta, Sanjeev Bhadresa, Steven Spencer Good, William Roger Rush, Hassan Rashidzadeh
Publikováno v:
Biologicalpharmaceutical bulletin. 38(3)
A conventional, rapid and high throughput method for tissue extraction and accurate and selective LC-MS/MS quantification of 2'-C-methylguanosine triphosphate (2'-MeGTP) in mouse liver was developed and qualified. Trichloroacetic acid (TCA) was used
Autor:
Peter C. Kind, Peter W. Vanderklish, Richard Paylor, Friso R. Postma, Mika Nakamoto Kinoshita, Mark F. Bear, Christopher Brynczka, Alexia M. Thomas, Lasani S. Wijetunge, Christina Henderson, Rebecca S. Hammond, Matthew Shumway, Stephen T. Warren, Roger Rush, Aileen M. Healy, Randall L. Carpenter
Publikováno v:
Sci Transl Med
Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism, results from the transcriptional silencing of FMR1 and loss of the mRNA translational repressor protein fragile X mental retardation protein (FMRP). Pati
Autor:
Donald F. Stec, Alice L. Rodriguez, Ryan D. Morrison, Anna L. Blobaum, Roger Rush, Daryl F. Venable, Katrina A. Brewer, Andrew S. Felts, Thomas M. Bridges, P. Jeffrey Conn, Kyle A. Emmitte, Craig W. Lindsley, Melany M. Corlew, Colleen M. Niswender, Tammy S. Santomango, Frank W. Byers, J. Scott Daniels, Raymundo Sanchez-Ponce, Carrie K. Jones, Brittney S. Bates, Jason Manka
Negative allosteric modulation (NAM) of metabotropic glutamate receptor subtype 5 (mGlu5) represents a therapeutic strategy for the treatment of childhood developmental disorders, such as fragile X syndrome and autism. VU0409106 emerged as a lead com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed0389e68c022ccf3e9d93be7fbdaf65
https://europepmc.org/articles/PMC3422546/
https://europepmc.org/articles/PMC3422546/
Publikováno v:
ACS chemical neuroscience. 2(8)
Intellectual disability (ID; mental retardation) is considered an immutable condition. Current medical practices are aimed at relieving symptoms and not at altering the underlying cognitive deficits. Scientific advancements from the past decade have