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Evaluation of matrix microsampling methods for therapeutic drug candidate quantification in discovery-stage rodent pharmacokinetic studies

Autor: Christopher A. James, Ronya Primack, Kevin Salyers, Roger Pham, Marc W. Retter, Valerie Almon, James Meyer, Mylo Wagner, Marcus Soto, Manuel Ponce

Publikováno v: Bioanalysis. 6:2135-2146

Background: AMG 517 or 1-aminobenzotriazole were quantified by LC–MS/MS from low blood/plasma volumes for rat pharmacokinetic (PK) characterization in order to qualify manual/automated dried blood spot (DBS) sampling and plasma separation capillary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b32bfa59d443f36c460df5cbd6324c09
https://doi.org/10.4155/bio.14.184

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Nonclinical Pharmacokinetics, Disposition, and Drug-Drug Interaction Potential of a Novel d-Amino Acid Peptide Agonist of the Calcium-Sensing Receptor AMG 416 (Etelcalcetide)

Autor: Sarah Walter, Roger Pham, Savannah J Kerr, Joel D Esmay, Xiaochun Zhu, Michael E. Fitzsimmons, Raju Subramanian, Gary L Skiles, Marcus Soto, Steven W Louie, Sarah F Wilson, Katheryne Z Edson, Mylo Wagner

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 44(8)

AMG 416 (etelcalcetide) is a novel synthetic peptide agonist of the calcium-sensing receptor composed of a linear chain of seven d-amino acids (referred to as the d-amino acid backbone) with a d-cysteine linked to an l-cysteine via a disulfide bond.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a3b78a29845db4808ed23d3bc60ec7
https://pubmed.ncbi.nlm.nih.gov/26895981

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Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived β-secretase inhibitors

Autor: Yi Luo, Stephen J. Wood, Toni Williamson, Jianhua Zhang, Thomas Dineen, Dean Hickman, Matthew R. Kaller, Kui Chen, Safura Babu-Khan, Li Zhu, Stephen Hitchcock, Joel Esmay, Roger Pham, Martin Citron, Wenge Zhong, Matthew Weiss, Paul H. Wen

Publikováno v: The Journal of pharmacology and experimental therapeutics. 343(2)

Sequential proteolytic cleavage of the amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex produces the amyloid-β peptide (Aβ), which is believed to play a critical role in the pathology of Alzheime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93da5a83637501d06058ebd8d15a85ca
https://pubmed.ncbi.nlm.nih.gov/22911925

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Critical review of p38 MAP kinase inhibitors: a bioanalytical perspective

Autor: Philip Wong, Roger Pham, Faye Hsieh, Christopher A. James

Publikováno v: Bioanalysis. 4(1)

p38 MAP kinase is a key enzyme in the proinflammatory response and a large number of compounds have been studied as potential therapeutic drugs. This review summarizes the bioanalytical methods used for the analysis of p38 MAP kinase inhibitors, with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05ce7c6a5a1edf798dc216fc2378099
https://pubmed.ncbi.nlm.nih.gov/22191596

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Application of automated dried blood spot sampling and LC-MS/MS for pharmacokinetic studies of AMG 517 in rats

Autor: Stacy Fide, Craig Uyeda, Kirk Henne, Marcus Soto, Guifen Xu, Philip Wong, Christopher A. James, Roger Pham

Publikováno v: Bioanalysis. 3(20)

Background: The use of dried blood spot (DBS) sampling technique is of particular interest for drug discovery pharmacokinetic studies due to the small blood volume requirement. In addition, automated blood sampling is an attractive approach for rat p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfa9b4f05dc8c6f739eca7edc39b0c7
https://pubmed.ncbi.nlm.nih.gov/22011182

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O1‐03‐02: Application of a physiologically relevant mathematical model supporting the quantitative importance of the clearance of brain Aβ peptide to CSF in the healthy normal rat

Autor: Dean Hickman, Stephen J. Wood, Paul H. Wen, Roger Pham, Claire Rattan, Li Zhu, Jan Zhang

Publikováno v: Alzheimer's & Dementia. 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::880c669def0ae4153465c2056b756fa1
https://doi.org/10.1016/j.jalz.2011.05.240

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Application of automated serial blood sampling and dried blood spot technique with liquid chromatography-tandem mass spectrometry for pharmacokinetic studies in mice

Autor: Roger Pham, Bernd A. Bruenner, Marcus Soto, Kevin Salyers, Carl Whitely, Philip Wong, Christopher A. James

Publikováno v: Journal of pharmaceutical and biomedical analysis. 56(3)

The goal of this work was to obtain full pharmacokinetic profiles from individual mice with the use of an automated blood sampling system and dried blood spot (DBS) technique. AMG 517, a potent and selective vanilloid receptor (VR1) antagonist, was d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a66f3e1037d6213c1abad0c2b8ca5033
https://pubmed.ncbi.nlm.nih.gov/21784595

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Increasing efficiency for dried blood spot analysis: prospects for automation and simplified sample analysis

Autor: Christopher A. James, Bernd A. Bruenner, Philip Wong, Roger Pham

Publikováno v: Bioanalysis. 2(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f80793732a563a8ed1450d9756220c3
https://pubmed.ncbi.nlm.nih.gov/21083483

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