Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Roger Patient"'
Autor:
Florian Bonkhofer, Rossella Rispoli, Philip Pinheiro, Monika Krecsmarik, Janina Schneider-Swales, Ingrid Ho Ching Tsang, Marella de Bruijn, Rui Monteiro, Tessa Peterkin, Roger Patient
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
HSCs emerge from haemogenic endothelium (HE) in the dorsal aorta but whether these tissues share a common lineage is unclear. Here, the authors use a zebrafish runx1 reporter to show that HE maintains an arterial gene expression profile in the absenc
Externí odkaz:
https://doaj.org/article/7daa7a5352524efcafc9c49f85909b86
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
How vegfa expression is transcriptionally regulated in vivo is unclear. Here, the authors demonstrate that the ETS transcription factor Etv6 acts as a repressor and an activator of two direct regulators of vegfa expression (foxo3 and klf4, respective
Externí odkaz:
https://doaj.org/article/ab8a78cea7274decb08b67fe512c423d
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 8, p e1006077 (2018)
The precise anatomical location of gene expression is an essential component of the study of gene function. For most model organisms this task is usually undertaken via visual inspection of gene expression images by interested researchers. Computatio
Externí odkaz:
https://doaj.org/article/51987c80ce4d4b14b5ba87f841520f4a
Publikováno v:
Biology Open, Vol 7, Iss 4 (2018)
Advances in genome engineering have resulted in the generation of numerous zebrafish mutant lines. A commonly used method to assess gene expression in the mutants is in situ hybridisation (ISH). Because the embryos can be distinguished by genotype af
Externí odkaz:
https://doaj.org/article/e92fcad6d8474171b10a1c80e2a5d356
Autor:
Kamel El Omari, Sarah J. Hoosdally, Kapil Tuladhar, Dimple Karia, Elisa Hall-Ponselé, Olga Platonova, Paresh Vyas, Roger Patient, Catherine Porcher, Erika J. Mancini
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 135-147 (2013)
Cell fate is governed by combinatorial actions of transcriptional regulators assembling into multiprotein complexes. However, the molecular details of how these complexes form are poorly understood. One such complex, which contains the basic-helix-lo
Externí odkaz:
https://doaj.org/article/180f59b26b2445988e1c27f96bd5d220
Autor:
Wenchao Gu, Rui Monteiro, Jie Zuo, Filipa Costa Simões, Andrea Martella, Charlotte Andrieu-Soler, Frank Grosveld, Tatjana Sauka-Spengler, Roger Patient
Publikováno v:
PLoS Biology, Vol 13, Iss 2, p e1002051 (2015)
As some of the most widely utilised intercellular signalling molecules, transforming growth factor β (TGFβ) superfamily members play critical roles in normal development and become disrupted in human disease. Establishing appropriate levels of TGF
Externí odkaz:
https://doaj.org/article/483dce2f3669423c8666a31f6fac061f
Publikováno v:
Open Biology, Vol 5, Iss 8 (2015)
Vertebrate NCoR-family co-repressors play central roles in the timing of embryo and stem cell differentiation by repressing the activity of a range of transcription factors. They interact with nuclear receptors using short linear motifs (SLiMs) terme
Externí odkaz:
https://doaj.org/article/0810c417bcfe45748aa1e9f30d3d40ea
Autor:
Hannah K Long, David Sims, Andreas Heger, Neil P Blackledge, Claudia Kutter, Megan L Wright, Frank Grützner, Duncan T Odom, Roger Patient, Chris P Ponting, Robert J Klose
Publikováno v:
eLife, Vol 2 (2013)
Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. In cold-blooded vertebrates, computational CGI predictions
Externí odkaz:
https://doaj.org/article/8f9b32865ca8491b8fcd154f9776e701
Autor:
Lucy J Patterson, Roger Patient
Publikováno v:
PLoS Biology, Vol 4, Iss 1, p e24 (2006)
Externí odkaz:
https://doaj.org/article/83ab670ce1ce401487e9eaa25bea64df
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2475
Unlike humans, the zebrafish can repair and regenerate its heart following injury. Understanding the molecular and physiological mechanisms of heart regeneration is critical in developing pro-regenerative strategies for clinical application. The card