Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Roger Parra"'
Publikováno v:
Laboratory Animal Research, Vol 40, Iss 1, Pp 1-9 (2024)
Abstract Background Immune profiling has become an important tool for identifying predictive, prognostic and response biomarkers for immune checkpoint inhibitors from tumor microenvironment (TME). We aimed to build a multiplex immunofluorescence (mIF
Externí odkaz:
https://doaj.org/article/3b17e624db3f456dafa76575f8f089af
Autor:
Gayatri Kumar, Renganayaki Krishna Pandurengan, Edwin Roger Parra, Kasthuri Kannan, Cara Haymaker
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Spatial modelling methods have gained prominence with developments in high throughput imaging platforms. Multiplex immunofluorescence (mIF) provides the scope to examine interactions between tumor and immune compartment at single cell resolution usin
Externí odkaz:
https://doaj.org/article/37021d317a1a430da88180de80092f3d
Autor:
Harsh Batra, Qingqing Ding, Renganayaki Pandurengan, Heladio Ibarguen, Neus Bota Rabassedas, Aysegul Sahin, Ignacio Wistuba, Edwin Roger Parra, Maria Gabriela Raso
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
As the second most common subtype of breast carcinoma, Invasive Lobular Carcinoma (ILC) microenvironment features have not been thoroughly explored. ILC has different histological subtypes and elucidating differences in their microenvironments could
Externí odkaz:
https://doaj.org/article/4c22d01179e347d7af41426ebeced3b5
Autor:
Jianhua Zhang, Hong Chen, Cara Haymaker, Elad Sharon, Razelle Kurzrock, Young Kwang Chae, Jiexin Zhang, Jack Lee, Jianjun Zhang, Ignacio Wistuba, Megan Othus, Sarah Fenton, Cristina Rodriguez, Adedayo Onitilo, Ahmad Mattour, Igor Rybkin, Christine McLeod, Helen Chen, Christopher Ryan, Melissa Plets, Charles Blanke, Gheath Al-Atrash, Rajyalakshmi Luthra, Hye Sung Kim, Dzifa Y Duose, Liam Il-Young Chung, Sandip P Patel, Yichen Lu, Edwin Roger Parra, Lorena Isabel Gomez Bolanos, Caddie Laberiano Fernandez, Luisa Solis Soto, Ganiraju Manyam, Gabby Lopez
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/07c970496cd1451ea6e94d54b2c67cd6
Immune cellular patterns of distribution affect outcomes of patients with non-small cell lung cancer
Autor:
Edwin Roger Parra, Jiexin Zhang, Mei Jiang, Auriole Tamegnon, Renganayaki Krishna Pandurengan, Carmen Behrens, Luisa Solis, Cara Haymaker, John Victor Heymach, Cesar Moran, Jack J. Lee, Don Gibbons, Ignacio Ivan Wistuba
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Studying the cellular geographic distribution in non-small cell lung cancer is essential to understand the roles of cell populations in this type of tumor. In this study, we characterize the spatial cellular distribution of immune cell popul
Externí odkaz:
https://doaj.org/article/37d883b1b0724befa4395d0a5874aeca
Autor:
Charles M. Bowen, Nan Deng, Laura Reyes-Uribe, Edwin Roger Parra, Pedro Rocha, Luisa M. Solis, Ignacio I. Wistuba, Valerie O. Sepeda, Lana Vornik, Marjorie Perloff, Eva Szabo, Asad Umar, Krishna M. Sinha, Powel H. Brown, Eduardo Vilar
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundRecent clinical trial data from Lynch Syndrome (LS) carriers demonstrated that naproxen administered for 6-months is a safe primary chemoprevention that promotes activation of different resident immune cell types without increasing lymphoid
Externí odkaz:
https://doaj.org/article/3d55b651927345eea41865d744b4c4c0
Autor:
Ming Chen, Runzhe Chen, Ying Jin, Jun Li, Xin Hu, Jiexin Zhang, Junya Fujimoto, Shawna M. Hubert, Carl M. Gay, Bo Zhu, Yanhua Tian, Nicholas McGranahan, Won-Chul Lee, Julie George, Xiao Hu, Yamei Chen, Meijuan Wu, Carmen Behrens, Chi-Wan Chow, Hoa H. N. Pham, Junya Fukuoka, Jia Wu, Edwin Roger Parra, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Chang-Jiun Wu, Lixia Diao, Qi Wang, Robert Cardnell, Jianhua Zhang, Jing Wang, Xiuning Le, Don L. Gibbons, John V. Heymach, J. Jack Lee, William N. William, Chao Cheng, Bonnie Glisson, Ignacio Wistuba, P. Andrew Futreal, Roman K. Thomas, Alexandre Reuben, Lauren A. Byers, Jianjun Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a col
Externí odkaz:
https://doaj.org/article/61c0fcf9baf94acab6feccd225cfafb0
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Externí odkaz:
https://doaj.org/article/72454fa0cb0640ebb1a0ff7cd06ab80c
Autor:
Hussein A. Abbas, Dapeng Hao, Katarzyna Tomczak, Praveen Barrodia, Jin Seon Im, Patrick K. Reville, Zoe Alaniz, Wei Wang, Ruiping Wang, Feng Wang, Gheath Al-Atrash, Koichi Takahashi, Jing Ning, Maomao Ding, Hannah C. Beird, Jairo T. Mathews, Latasha Little, Jianhua Zhang, Sreyashi Basu, Marina Konopleva, Mario L. Marques-Piubelli, Luisa M. Solis, Edwin Roger Parra, Wei Lu, Auriole Tamegnon, Guillermo Garcia-Manero, Michael R. Green, Padmanee Sharma, James P. Allison, Steven M. Kornblau, Kunal Rai, Linghua Wang, Naval Daver, Andrew Futreal
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The response rate of relapsed/refractory acute myeloid leukemia patients to PD-1 checkpoint blockade is low and unpredictable. Authors here show by single cell RNA sequencing, T cell receptor profiling and genomic analysis that the phenotypes and rep
Externí odkaz:
https://doaj.org/article/28224d44710d40fe8758d8643917f98e
Autor:
Frank Rojas, Sharia Hernandez, Rossana Lazcano, Caddie Laberiano-Fernandez, Edwin Roger Parra
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
A robust understanding of the tumor immune environment has important implications for cancer diagnosis, prognosis, research, and immunotherapy. Traditionally, immunohistochemistry (IHC) has been regarded as the standard method for detecting proteins
Externí odkaz:
https://doaj.org/article/1ba543477e424907aa889e535b7e9526