Condensin ATPase motifs contribute differentially to the maintenance of chromosome morphology and genome stability.

Autor: Roger Palou, Thillaivillalan Dhanaraman, Rim Marrakchi, Mirela Pascariu, Mike Tyers, Damien D'Amours

Publikováno v: PLoS Biology, Vol 16, Iss 6, p e2003980 (2018)

Effective transfer of genetic information during cell division requires a major reorganization of chromosome structure. This process is triggered by condensin, a conserved pentameric ATPase essential for chromosome condensation. How condensin harness

Externí odkaz: https://doaj.org/article/2a622fb424ae4306bc2b89f863cb3170

Graph-Based Active Machine Learning Method for Diverse and Novel Antimicrobial Peptides Generation and Selection

Autor: Bonaventure F. P. Dossou, Dianbo Liu, Xu Ji, Moksh Jain, Almer M. van der Sloot, Roger Palou, Michael Tyers, Yoshua Bengio

As antibiotic-resistant bacterial strains are rapidly spreading worldwide, infections caused by these strains are emerging as a global crisis causing the death of millions of people every year. Antimicrobial Peptides (AMPs) are one of the candidates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ed7ed4b825e7fd73ad5cd3e1a9556b0

The microprotein Nrs1 rewires the G1/S transcriptional machinery during nitrogen limitation in budding yeast

Autor: Sylvain Tollis, Jaspal Singh, Roger Palou, Yogitha Thattikota, Ghada Ghazal, Jasmin Coulombe-Huntington, Xiaojing Tang, Susan Moore, Deborah Blake, Eric Bonneil, Catherine A. Royer, Pierre Thibault, Mike Tyers

Publikováno v: PLoS biology. 20(3)

Commitment to cell division at the end of G1 phase, termed Start in the budding yeast Saccharomyces cerevisiae, is strongly influenced by nutrient availability. To identify new dominant activators of Start that might operate under different nutrient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7e3454fb2f7303962ca76c1a404d18
https://pubmed.ncbi.nlm.nih.gov/35259158

G1 cyclin driven DNA replication

Autor: Gloria Palou, Asrar Malik, David G. Quintana, Ping Ren, Roger Palou, Fanli Zeng

Publikováno v: Cell Cycle. 14:3842-3850

The mitotic cell cycle is driven by Cyclin-Dependent Kinases (CDK). CDK activation requires the binding of activatory subunits termed cyclins. Different waves of cyclins are expressed during the cell cycle, enabling CDKs to trigger phase specific eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc334ed3f957365795ae655c6a36f4c
https://doi.org/10.1080/15384101.2015.1070995

A role for the spindle assembly checkpoint in the DNA damage response

Autor: Roger Palou, David G. Quintana, Gloria Palou

Publikováno v: Current Genetics
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Spontaneous DNA damage poses a continuous threat to genomic integrity. If unchecked, genotoxic insults result in genomic instability, a hallmark of cancer cells. In eukaryotic cells a DNA Damage Response (DDR) detects and responds to genotoxic stress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::073af7436f2787c11fcd70fdc9471081
https://pubmed.ncbi.nlm.nih.gov/27488803