Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Roger Oria"'
1
Akademický článek
A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer
Autor: Connor Stashko, Mary-Kate Hayward, Jason J. Northey, Neil Pearson, Alastair J. Ironside, Johnathon N. Lakins, Roger Oria, Marie-Anne Goyette, Lakyn Mayo, Hege G. Russnes, E. Shelley Hwang, Matthew L. Kutys, Kornelia Polyak, Valerie M. Weaver
Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Intratumor heterogeneity associates with poor patient outcome. Stromal stiffening also accompanies cancer. Whether cancers demonstrate stiffness heterogeneity, and if this is linked to tumor cell heterogeneity remains unclear. We developed a
Externí odkaz: https://doaj.org/article/8eef1f697e6d46898510e81e54f4c1d8
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2
Akademický článek
Finite Element Analysis of Electrically Excited Quartz Tuning Fork Devices
Autor: Manel Puig-Vidal, Manuel Carmona, Laura González, Luis Botaya, Jorge Otero, Roger Oria
Publikováno v: Sensors, Vol 13, Iss 6, Pp 7156-7169 (2013)
Quartz Tuning Fork (QTF)-based Scanning Probe Microscopy (SPM) is an important field of research. A suitable model for the QTF is important to obtain quantitative measurements with these devices. Analytical models have the limitation of being based o
Externí odkaz: https://doaj.org/article/4fc6f25170084a67bbe37c8a4fdba4ba
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4
A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
Autor: Elena Garreta, Patricia Prado, Megan L. Stanifer, Vanessa Monteil, Andrés Marco, Asier Ullate-Agote, Daniel Moya-Rull, Amaia Vilas-Zornoza, Carolina Tarantino, Juan Pablo Romero, Gustav Jonsson, Roger Oria, Alexandra Leopoldi, Astrid Hagelkruys, Maria Gallo, Federico González, Pere Domingo-Pedrol, Aleix Gavaldà, Carmen Hurtado del Pozo, Omar Hasan Ali, Pedro Ventura-Aguiar, Josep María Campistol, Felipe Prosper, Ali Mirazimi, Steeve Boulant, Josef M. Penninger, Nuria Montserrat
Publikováno v: CELL METABOLISM
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
Cell Metab.
It is not well understood why diabetic individuals are more prone to develop severe COVID-19. To this, we here established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development. Upon SARS-CoV-2 infection, diab
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::851d0dbb5ac5f6528236567977b01eff
https://doi.org/10.1016/j.cmet.2022.04.009
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6
Cell Migration: Deconstructing the Matrix
Autor: Roger Oria, Alberto Elosegui-Artola
Publikováno v: Curr Biol
Integrin-ligand interaction mediates the adhesion and migration of many metazoan cells. Here, we report a unique mode of cell migration elicited by the lability of integrin ligands. We found that stationary cells spontaneously turn migratory on subst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2e46e1f153b91697884ce9aef5f375
https://pubmed.ncbi.nlm.nih.gov/32916117
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7
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
Autor: Carolina Tarantino, Dobryna Zalvidea, Pere Roca-Cusachs, Juan Carlos Izpisua Belmonte, Nuria Montserrat, Josep M. Campistol, Lucia Fanlo, Elena Garreta, Elisa Martí, Luca Cozzuto, Aleix Gavaldà-Navarro, Roger Oria, Patrícia Rezende do Prado, Xavier Trepat, Carmen Hurtado del Pozo
Publikováno v: Nature Materials
Dipòsit Digital de la UB
Universidad de Barcelona
Nat Mater
Digital.CSIC. Repositorio Institucional del CSIC
instname
The generation of organoids is one of the biggest scientific advances in regenerative medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were exposed to a three-dimensional microenvironment, and by applying defined rena
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7ab1e49a93f65f57cfa2e8664b1b17
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8
Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity
Autor: Cheng Zhu, Yunfeng Chen, Xavier Trepat, Alberto Elosegui-Artola, Pere Roca-Cusachs, Roger Oria, Carlos Pérez-González, Anita Joanna Kosmalska, Natalia Castro
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Cell function depends on tissue rigidity, which cells probe by applying and transmitting forces to their extracellular matrix, and then transducing them into biochemical signals. Here we show that in response to matrix rigidity and density, force tra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4027b4a91da1f568974c5ac41e0f875
https://doi.org/10.1038/ncb3336
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9
Force loading explains spatial sensing of ligands by cells
Autor: Cristian Moreno-Pulido, Jorge Escribano, José Manuel García-Aznar, Roger Oria, Pietro Delcanale, Xavier Trepat, Ilia Platzman, Daniel Navajas, Elisabetta Ada Cavalcanti-Adam, Juan J. Uriarte, Alberto Elosegui-Artola, Tina Wiegand, Lorenzo Albertazzi, Pere Roca-Cusachs
Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Nature
Nature, 552(7684), 219-224. Nature Publishing Group
Cells can sense the density and distribution of extracellular matrix (ECM) molecules by means of individual integrin proteins and larger, integrin-containing adhesion complexes within the cell membrane. This spatial sensing drives cellular activity i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d872242670b2e957143f09ff59f95a1d
https://pubmed.ncbi.nlm.nih.gov/29211717
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10
Determination of the static spring constant of electrically-driven quartz tuning forks with two freely oscillating prongs
Autor: Laura M. Gonzalez, Manel Puig-Vidal, Luis Botaya, Roger Oria, Jorge Otero
Publikováno v: Nanotechnology. 26(5)
Quartz tuning forks have become popular in nanotechnology applications, especially as sensors for scanning probe microscopy. The sensor's spring constant and the oscillation amplitude are required parameters to evaluate the tip-sample forces; however
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5846a963aa54d649915e3670a5819a60
https://pubmed.ncbi.nlm.nih.gov/25573912
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