Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Roger Negrete"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Opioid agonists are powerful drugs for managing pain. However, their central side effects are limiting their use and drugs with similar potency, but a lower risk profile are needed. (±)-N-(3-fluoro-1-phenethylpiperidine-4-yl)-N-phenylpropio
Externí odkaz:
https://doaj.org/article/330afafbfd49494f949d6c9ad8fad09b
Publikováno v:
Osteoarthritis and Cartilage. 28:475-485
Summary Objective To investigate sex effects on pain-related behaviors in the medial meniscal transection (MMT) knee osteoarthritis (OA) model. Methods Experiments were performed in male and female C57BL/6J mice (12/group/sex). MMT was induced by tra
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43693 (2012)
Carbon monoxide (CO) synthesized by heme oxygenase 1 (HO-1) exerts antinociceptive effects during inflammation but its role during neuropathic pain remains unknown. Our objective is to investigate the exact contribution of CO derived from HO-1 in the
Externí odkaz:
https://doaj.org/article/e05a302e22144b2e897dc5345b5d794c
Autor:
Marcus Weber, Dominika Labuz, Michael Kloner, Antonio Rodriguez-Gaztelumendi, Giovanna Del Vecchio, Christoph Stein, Roger Negrete, Viola Seitz, Halina Machelska, Julia Temp
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports
The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-d
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26688 (2011)
Cannabinoid 2 receptor (CB2R) agonists attenuate inflammatory pain but the precise mechanism implicated in these effects is not completely elucidated. We investigated if the peripheral nitric oxide-cGMP-protein kinase G (PKG)-ATP-sensitive K(+) (KATP
Externí odkaz:
https://doaj.org/article/20d8dc1e986d48c8a411b2c799cce3dd
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14321 (2010)
BACKGROUND: Nitric oxide generated by neuronal (NOS1), inducible (NOS2) or endothelial (NOS3) nitric oxide synthases contributes to pain processing, but the exact role of NOS1 and NOS2 in the maintenance of chronic peripheral neuropathic pain as well
Externí odkaz:
https://doaj.org/article/f5798182bc0b4cbda1d4afe0721ec3b2
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
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Joint pain is a major clinical problem mainly associated to osteoarthritis, and characterized by articular cartilage degradation resulting in a complex chronic pain state that includes nociceptive, emotional and cognitive manifestations. Memory impai
Autor:
Halina Machelska, Viola Seitz, Antonio Rodriguez-Gaztelumendi, Giovanna Del Vecchio, Christoph Stein, Marcus Weber, Michael Kloner, Roger Negrete, Dominika Labuz, Julia Temp
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-2 (2020)
Scientific Reports
Scientific Reports
The non-selective activation of central and peripheral opioid receptors is a major shortcoming of currently available opioids. Targeting peripheral opioid receptors is a promising strategy to preclude side effects. Recently, we showed that fentanyl-d
Autor:
Wiktor Bilecki, Agnieszka Wawrzczak-Bargiela, Ryszard Przewlocki, Leonor Gonçalves, Anthony H. Dickenson, Miriam Martínez-Navarro, Josep-Eladi Baños, Roger Negrete, Itzel Montserrat Lara-Mayorga, Rafael Maldonado
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
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Neuropathic pain is a complex disorder associated with emotional and cognitive deficits that may impair nociceptive manifestations. There is high inter-individual variability in the manifestations of human neuropathic pain, which largely depends on p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac83fd2fd4036b09bd4bf04bf085036
http://hdl.handle.net/10230/36362
http://hdl.handle.net/10230/36362
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
instname
BACKGROUND: Preclinical drug discovery for the treatment of chronic pain is at present challenged by the difficulty to study behaviours comparable to the complex human pain experience in animals. Several reports have demonstrated a frequent associati