Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Roger MacKenzie"'
Autor:
Kasandra Bélanger, Umar Iqbal, Jamshid Tanha, Roger MacKenzie, Maria Moreno, Danica Stanimirovic
Publikováno v:
Antibodies, Vol 8, Iss 2, p 27 (2019)
Antibodies have become one of the most successful therapeutics for a number of oncology and inflammatory diseases. So far, central nervous system (CNS) indications have missed out on the antibody revolution, while they remain ‘hidden’ behind seve
Externí odkaz:
https://doaj.org/article/7b22f59c982c40d59c315b497fd6127f
Publikováno v:
Sensors, Vol 9, Iss 7, Pp 5351-5367 (2009)
Antibody engineering has allowed for the rapid generation of binding agents against virtually any antigen of interest, predominantly for therapeutic applications. Considerably less attention has been given to the development of diagnostic reagents an
Externí odkaz:
https://doaj.org/article/f7864cc4b59d49a6904efded8873cf12
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 7, Pp 1399-1405 (2006)
To obtain a panel of monoclonal antibodies (MAbs) to study the folding and conformation of the low density lipoprotein receptor (LDLr), we have generated hybridomas from LDLr-deficient mice that had been immunized with the extracellular domain of the
Externí odkaz:
https://doaj.org/article/7e144b8dcc4b4e2b86f77f0ee838df35
Autor:
Gabrielle Richard, Ashley J Meyers, Michael D McLean, Mehdi Arbabi-Ghahroudi, Roger MacKenzie, J Christopher Hall
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69495 (2013)
Small recombinant antibody fragments (e.g. scFvs and VHHs), which are highly tissue permeable, are being investigated for antivenom production as conventional antivenoms consisting of IgG or F(ab')2 antibody fragments do not effectively neutralize ve
Externí odkaz:
https://doaj.org/article/8cb147b012534ae4925d5a353a4eabbd
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55098 (2013)
Listeria monocytogenes serotype 4b is responsible for a high percentage of fatal cases of food-borne infection. In a previous study, we created 15 monoclonal antibodies (MAbs) against a ≈ 77 kDa antigen that is associated with the cell surface of l
Externí odkaz:
https://doaj.org/article/2bd1328e4e44450ab86d469a3c1f9fd5
Autor:
Ali Riazi, Philippa C R Strong, Russell Coleman, Wangxue Chen, Tomoko Hirama, Henk van Faassen, Matthew Henry, Susan M Logan, Christine M Szymanski, Roger Mackenzie, Mehdi Arbabi Ghahroudi
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83928 (2013)
Campylobacter jejuni is the leading cause of bacterial foodborne illness in the world, with symptoms ranging from acute diarrhea to severe neurological disorders. Contaminated poultry meat is a major source of C. jejuni infection, and therefore, stra
Externí odkaz:
https://doaj.org/article/12ad248f0170417794ff4b59f54cd3f8
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e28218 (2011)
The extreme pH and protease-rich environment of the upper gastrointestinal tract is a major obstacle facing orally-administered protein therapeutics, including antibodies. Through protein engineering, several Clostridium difficile toxin A-specific he
Externí odkaz:
https://doaj.org/article/b24e4679d3a64b85b9233518ddbe5e16
Autor:
Shakeeba Waseh, Pejman Hanifi-Moghaddam, Russell Coleman, Michael Masotti, Shannon Ryan, Mary Foss, Roger MacKenzie, Matthew Henry, Christine M Szymanski, Jamshid Tanha
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13904 (2010)
One of the major causes of morbidity and mortality in man and economically important animals is bacterial infections of the gastrointestinal (GI) tract. The emergence of difficult-to-treat infections, primarily caused by antibiotic resistant bacteria
Externí odkaz:
https://doaj.org/article/8dca2afd1c054f2ebbf5363e4a6819e1
Autor:
Seung-Hwan Lee, Michael J. Lowden, Dong-Hyeon Jo, Shannon Ryan, Greg Hussack, Henk van Faassen, Shalini Raphael, Kevin A. Henry, C. Roger MacKenzie
Publikováno v:
Molecular Pharmaceutics. 18:2375-2384
Multispecific antibodies that bridge immune effector and tumor cells have shown promising preclinical and clinical efficacies. Here, we isolated and characterized novel llama single-domain antibodies (sdAbs) against CD16. One sdAb, NRC-sdAb048, bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0ec42ea53adbcee4e44d145a475bb3
https://doi.org/10.1021/acs.molpharmaceut.1c00208
https://doi.org/10.1021/acs.molpharmaceut.1c00208
Autor:
Kevin A. Henry, Shalini Raphael, Henk van Faassen, Qingling Yang, Martin A Rossotti, Shannon Ryan, Susan Jiang, Eric Brunette, C. Roger MacKenzie, Traian Sulea, Arsalan S. Haqqani, Greg Hussack, Jamshid Tanha
Publikováno v:
The FASEB Journal. 34:8155-8171
Prolonged serum half-life is required for the efficacy of most protein therapeutics. One strategy for half-life extension is to exploit the long circulating half-life of serum albumin by incorporating a binding moiety that recognizes albumin. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18b062f15541be828a00df429717a65
https://doi.org/10.1096/fj.201903231r
https://doi.org/10.1096/fj.201903231r