Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Roger M. Wadsworth"'
Autor:
Junxi Wu, Gianluca Grassia, Helen Cambrook, Armando Ialenti, Neil MacRitchie, Jaclyn Carberry, Roger M. Wadsworth, Catherine Lawrence, Simon Kennedy, Pasquale Maffia
Publikováno v:
PeerJ, Vol 3, p e1192 (2015)
Objective. Emerging evidence suggests an important role for mast cells in vein graft failure. This study addressed the hypothesis that perivascular mast cells regulate in situ vascular inflammatory and proliferative responses and subsequent vein graf
Externí odkaz:
https://doaj.org/article/98c56c9518df49e3958466d9420532f6
Publikováno v:
Pharmacology & Therapeutics. 138:53-65
Mast cells are increasingly being recognized as effector cells in many cardiovascular conditions. Many mast-cell-derived products such as tryptase and chymase can, through their enzymic action, have detrimental effects on blood vessel structure while
Publikováno v:
Wu, J, Lawrence, C E, Wadsworth, R M & Kennedy, S 2017, ' Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. ', Vessel Plus . https://doi.org/10.20517/2574-1209.2017.15
Aim: Mast cells are versatile innate immune cells and are reported to promote vascular\ud inflammation and neointimal lesion formation, thereby contributing to the development of\ud vascular stenosis and atherosclerosis. However, it is not clear whet
Publikováno v:
BASE-Bielefeld Academic Search Engine
Drug-eluting stents have been successful in reducing in-stent restenosis but are not suitable for all lesion types and have been implicated in causing late stent thrombosis due to incomplete regeneration of the endothelial cell layer. In this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c09c64819729b4b6139e4629d3616dc
https://strathprints.strath.ac.uk/56716/1/McCormick_etal_PP2016_polymer_coated_cicaprost_eluting_stent_increases_neointima_formation.pdf
https://strathprints.strath.ac.uk/56716/1/McCormick_etal_PP2016_polymer_coated_cicaprost_eluting_stent_increases_neointima_formation.pdf
Resistance arteries have been implicated as major contributing factor in the sequela of disease conditions such as hypertension and diabetes and as such are a major focus of cardiovascular research. The paracrine influence of the intimal endothelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e23c792cf594249e4e27f4ee40fd2f
https://strathprints.strath.ac.uk/57628/1/Zainalabidin_etal_AB_2016_Adventitial_ablation_technique_that_permits_the_assessment_of_adventitial.pdf
https://strathprints.strath.ac.uk/57628/1/Zainalabidin_etal_AB_2016_Adventitial_ablation_technique_that_permits_the_assessment_of_adventitial.pdf
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 47:140-148
Hypoxic pulmonary hypertension is a worldwide public health problem. Statins attenuate hypoxic pulmonary hypertension in animal models, but the mechanism of action and applicability of these results to human treatment are not established. In hypoxic
Autor:
Jonathan Watt, Simon Kennedy, Keith G. Oldroyd, Marie-Ann Ewart, Roger M. Wadsworth, Fiona H. Greig
Publikováno v:
Thrombosis Research
Background The effect of reactive oxygen species (ROS) on platelet function in coronary heart disease (CHD) is complex and poorly defined. Platelet aggregation studies in healthy volunteers have demonstrated contrasting results when platelets are exp
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 80:578-584
The present study is an attempt to leverage therapeutic benefits of curcumin in pulmonary hypertension by encapsulating it in biodegradable poly(lactide-co-glycolic) acid nanoparticles. Pulmonary hypertension is induced in experimental animals by sub
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:584-588
There is separate evidence for peroxynitrite formation and hypoxia-induced cell proliferation in several models of hypoxic pulmonary hypertension. We therefore hypothesized that the stimulation of pulmonary artery smooth muscle cells (PASMCs) prolife
Publikováno v:
Journal of Biomedical Nanotechnology. 7:300-307
Cyclosporine (CsA) as an immunosuppressant has demonstrated immense potential in the field of organ transplantation and autoimmune disorders, despite the nephrotoxicity. The present investigation is an attempt to develop biodegradable nanoparticles e