Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Roger M. Loria"'
Autor:
Roger M Loria
Publikováno v:
Journal of Antivirals & Antiretrovirals.
Autor:
Roger M. Loria
Publikováno v:
Advances in Neuroimmune Biology. 5:33-42
Androstene steroids up-regulate immunity to increase host resistance against lethal infection by viruses, bacteria, and parasites. They also repair injury after lethal radiation exposure by mediating a rapid recovery of hematopoietic precursor cells.
Publikováno v:
Advances in Neuroimmune Biology. 5:99-107
Carriers of the tapeworm Taenia solium are the main risk factor in the transmission of both human neurocysticercosis and porcine cysticercosis. One quarter of the world’s human population is exposed to intestinal helminthic parasites; consequently,
Autor:
Martin R. Graf, Roger M. Loria
Publikováno v:
Annals of the New York Academy of Sciences. 1262:127-133
Δ5-androstene-3β,17α-diol (17α-AED) mediates oncophagy of human myeloid, glioma, and breast tumor cells by apoptotic- and autophagic-programmed cell death pathways, whereas the 17β-epimer does not. In hematologically derived myeloid tumor cells,
Autor:
Laura Thompson, Mathew Beckman, David R. Gibb, Francisco Tamariz, Peter Guida, Daniel Contaifer, Roger M. Loria
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 26:453-459
Space exploration is associated with exposure to 1-3 Gy solar particle radiation and galactic cosmic radiation that could increase cancer rates. Effective nontoxic countermeasures to high linear energy transfer (LET) radiation exposure are highly des
Autor:
V. Ramana Feeser, Roger M. Loria
Publikováno v:
Journal of Neuroimmunology. 237:4-12
TBI is a complex disease process caused by a cascade of systemic events. Attention is now turning to drugs that act on multiple pathways to enhance survival and functional outcomes. Progesterone has been found to be beneficial in several animal speci
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 42:2019-2029
In this study, we identified a mechanism by which the neuro-steroid, 5-androstene 3β,17α diol (17α-AED) induces autophagy in human malignant glioma cells and transformed fibroblasts. 17α-AED treatment induced endoplasmic reticulum (ER) stress, id
Publikováno v:
Chemical Biology & Drug Design. 74:625-629
Androstene steroids are metabolites of dehydroepiandrosterone and exist as androstene-diols or -triols in alpha- and beta-epimeric forms based upon the placement of the hydroxyl groups relative to the plane of the Delta(5)cycloperhydrophenanthrene ri
Publikováno v:
Wound Repair and Regeneration. 17:758-761
It is well recognized that stress of any nature will cause a delay in the wound healing response. This delayed healing response appears closely associated with immune regulators. In this study, CD-1 mice were injected with a long acting form of methy
Autor:
Rao R. Ivatury, Kristin E. Paccione, Andreea C. Marcu, Kevin R. Ward, R. Wayne Barbee, Robert F. Diegelmann, Roger M. Loria
Publikováno v:
Journal of Trauma: Injury, Infection & Critical Care. 63:662-669
Background: Traumatic shock activates the hypothalamic-pituitary-adrenal axis (HPA) to mediate a cascade of defensive mechanisms that often include overwhelming inflammatory response and immunosuppression, which may lead to multiple organ failure. An