Onset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers

Autor: Roger M. Lane, Taher Darreh-Shori, Candice Junge, Dan Li, Qingqing Yang, Amanda L. Edwards, Danielle L. Graham, Katrina Moore, Catherine J. Mummery

Publikováno v: BMC Neurology, Vol 24, Iss 1, Pp 1-16 (2024)

Abstract Background The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers. Methods Patients aged 50–74 years with cerebrospinal flu

Externí odkaz: https://doaj.org/article/730fc122897643a1aee9109ee499d3ab

Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

Autor: Catherine J. Mummery, Anne Börjesson-Hanson, Daniel J. Blackburn, Everard G. B. Vijverberg, Peter Paul De Deyn, Simon Ducharme, Michael Jonsson, Anja Schneider, Juha O. Rinne, Albert C. Ludolph, Ralf Bodenschatz, Holly Kordasiewicz, Eric E. Swayze, Bethany Fitzsimmons, Laurence Mignon, Katrina M. Moore, Chris Yun, Tiffany Baumann, Dan Li, Daniel A. Norris, Rebecca Crean, Danielle L. Graham, Ellen Huang, Elena Ratti, C. Frank Bennett, Candice Junge, Roger M. Lane

Publikováno v: Nature medicine 29(6), 1437-1447 (2023). doi:10.1038/s41591-023-02326-3
Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
Nature Medicine. Nature Publishing Group
Nature Medicine, 29, 1437-1447. Nature Publishing Group

Tau plays a key role in Alzheimer’s disease (AD) pathophysiology, and accumulating evidence suggests that lowering tau may reduce this pathology. We sought to inhibit MAPT expression with a tau-targeting antisense oligonucleotide (MAPTRx) and reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4826e86379fe0686cd40f5d60108ba
https://doi.org/10.1038/s41591-023-02326-3

List of contributors

Autor: Nicholas Ah Mew, Wado Akamatsu, Hasan Orhan Akman, Afnan AlHakeem, Koji Aoyama, Rafael Artuch, Michael Beck, C. Frank Bennett, Gerard T. Berry, D. Montgomery Bissell, Brenda Canine, C. Thomas Caskey, Widler Casy, Patrick F. Chinnery, David T. Chuang, Emily K. Cook, Rody P. Cox, Philip L. De Jager, Didem Demirbas, Robert J. Desnick, Salvatore DiMauro, Florian S. Eichler, Bernice Elger, Valentina Emmanuele, Patricia Evans, Brent L. Fogel, Àngels García-Cazorla, Cinzia Gellera, Sailaja Golla, Kimberly Goodspeed, Sidney M. Gospe, Steven J. Gray, Andrea L. Gropman, Yian Gu, Renzo Guerrini, Teresa M. Gunn, Una Hadziahmetovic, Darrah Haffner, R.J. Hagerman, Tamar Harel, Elizabeth Head, Rita Horvath, Yasushi Hosoi, Ying-Chen Claire Hou, Jane Hsiao, Hiroyuki Ishiura, Clifford R. Jack, Vikram Jakkamsetti, William G. Johnson†, Fabrice Jotterand, John P. Kane, Olga Khorkova, Chisato Kinoshita, Sanne E. Klompe, Lisa M. Koehl, Michael C. Kruer, Walter A. Kukull, Roger M. Lane, Joseph H. Lee, M.J. Leigh, Qinglan Ling, James R. Lupski, Paola Luzi, Qian Ma, Gustavo H.B. Maegawa, Mary J. Malloy, Seth S. Margolis, Isaac Marin-Valencia, James A. Mastrianni, Dena Matalon, Reuben Matalon, Kimberlee Michals Matalon Rd, Jennifer M. Mathews, Richard Mayeux, Jennifer McCurdy, Meira R. Meltzer, John H. Menkes†, Justin Miron, Jun Mitsui, Hiroaki Miyajima, Lisa M. Monteggia, Mary Ann Morris, Hugo W. Moser†, Melissa E. Murray, Toshio Nakaki, Nathalie Nilsson, Ichizo Nishino, Sandra M.H. Nordlie, Robert L. Nussbaum, William L. Nyhan, Hideyuki Okano, Sergio Padilla-Lopez, Elena Parrini, Juan M. Pascual, Gregory M. Pastores, Shailendra B. Patel, Marc C. Patterson, Izabella A. Pena, Cynthia Picard, Judes Poirier, Jennifer E. Posey, Gerald V. Raymond, William Renthal, David S. Rosenblatt, Francis Rossignol, Gerald Salen, Konrad Sandhoff, Raphael Schiffmann, Detlev Schindler, Frederick A. Schmitt, Susanne A. Schneider, Eric A. Schon, Edward H. Schuchman, Margretta Reed Seashore, Frances C. Shaffo, Michael Shevell, Sarah E. Sinnett, Myriam Srour, Samuel H. Sternberg, Kazuma Sugie, Kristen L. Szabla, Franco Taroni, Marina Tedeschi Dauar, Shoji Tsuji, Wendy R. Uhlmann, Clara van Karnebeek, Kathryn L. Van Pelt, Prashanthi Vemuri, Charles P. Venditti, Claes Wahlestedt, Bruce Wang, David Watkins, David A. Wenger, Charles A. Williams, Golder N. Wilson, Barry Wolf, R. Max Wynn, Hung-Chun Yu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57d33606a0dd70f9459d3237b2c69dcb
https://doi.org/10.1016/b978-0-12-813955-4.00079-9

A safety, tolerability and biomarker update from an ongoing open-label extension study of RG6042 in adults with early manifest Huntington’s disease

Autor: V. Schlegel, Roger M. Lane, G. Hooper, L. Boak, A. Nicotra, Blair R. Leavitt, J. Chevure, Anne Smith, R. Doody, Sarah J. Tabrizi, Edward J. Wild, P. Sanwald Ducray, F. Bennett, Scott Schobel

Publikováno v: Journal of the Neurological Sciences. 405:26-27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a123d609dd2fc7a23d2545be8424a7e
https://doi.org/10.1016/j.jns.2019.10.260

Safety, pharmacokinetic, and positron emission tomography evaluation of serotonin and dopamine transporter occupancy following multiple-dose administration of the triple monoamine reuptake inhibitor BMS-820836

Autor: Roger M. Lane, Matthew Cahir, David Burt, Zubin Bhagwagar, Robert Risinger, Sanjay Keswani, Gunnar Antoni, Feng Luo, Lieuwe Appel, Ming Zheng, Wendy Hayes

Publikováno v: Psychopharmacology. 232(3)

BMS-820836 is a novel antidepressant that selectively inhibits the reuptake of serotonin, norepinephrine, and dopamine.This Phase I study assessed safety, tolerability, and pharmacokinetics of multiple daily doses of BMS-820836 in healthy subjects. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a84fdea99e46d0a62e342b8d6c8aed
https://pubmed.ncbi.nlm.nih.gov/25116481