Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Roger M. Nitsch"'
Autor:
Dario Bachmann, Bettina von Rickenbach, Andreas Buchmann, Martin Hüllner, Isabelle Zuber, Sandro Studer, Antje Saake, Katrin Rauen, Esmeralda Gruber, Roger M. Nitsch, Christoph Hock, Valerie Treyer, Anton Gietl
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background White matter hyperintensities (WMHs) are often measured globally, but spatial patterns of WMHs could underlie different risk factors and neuropathological and clinical correlates. We investigated the spatial heterogeneity of WMHs
Externí odkaz:
https://doaj.org/article/9316f1cf723c4c199d401eb6f29905b8
Autor:
Fabian Wirth, Fabrice D. Heitz, Christine Seeger, Ioana Combaluzier, Karin Breu, Heather C. Denroche, Julien Thevenet, Melania Osto, Paolo Arosio, Julie Kerr-Conte, C. Bruce Verchere, François Pattou, Thomas A. Lutz, Marc Y. Donath, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract In patients with type 2 diabetes, pancreatic beta cells progressively degenerate and gradually lose their ability to produce insulin and regulate blood glucose. Beta cell dysfunction and loss is associated with an accumulation of aggregated
Externí odkaz:
https://doaj.org/article/68eb80d31bdf42208e648a12724a93bf
Autor:
Dario Bachmann, Andreas Buchmann, Sandro Studer, Antje Saake, Katrin Rauen, Isabelle Zuber, Esmeralda Gruber, Roger M. Nitsch, Christoph Hock, Anton Gietl, Valerie Treyer
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract This work aimed to investigate potential pathways linking age and imaging measures to early age- and pathology-related changes in cognition. We used [18F]-Flutemetamol (amyloid) and [18F]-Flortaucipir (tau) positron emission tomography (PET)
Externí odkaz:
https://doaj.org/article/4717f08dff1745039daa2b751a635298
Autor:
Dario Bachmann, Andreas Buchmann, Sandro Studer, Antje Saake, Katrin Rauen, Esmeralda Gruber, Roger M. Nitsch, Christoph Hock, Anton Gietl, Valerie Treyer
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 1, Pp n/a-n/a (2024)
Abstract INTRODUCTION Female sex is associated with increased [18F]‐flortaucipir signal, which may be affected by amyloid pathology, age, and off‐target binding in skull and meninges. METHODS In this cross‐sectional study comprising 52 females
Externí odkaz:
https://doaj.org/article/13d6b906f6e9404db35968971660f5b7
Autor:
Junhao Zhang, Valerie Treyer, Junfeng Sun, Chencheng Zhang, Anton Gietl, Christoph Hock, Daniel Razansky, Roger M. Nitsch, Ruiqing Ni
Publikováno v:
Brain Stimulation, Vol 16, Iss 2, Pp 653-656 (2023)
Externí odkaz:
https://doaj.org/article/68c128db0850487898bbaa1dd819a049
Autor:
Ruslan Rust, Rebecca Z. Weber, Melanie Generali, Debora Kehl, Chantal Bodenmann, Daniela Uhr, Debora Wanner, Kathrin J. Zürcher, Hirohide Saito, Simon P. Hoerstrup, Roger M. Nitsch, Christian Tackenberg
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Background Currently, there is no regenerative therapy for patients with neurological and neurodegenerative disorders. Cell-therapies have emerged as a potential treatment for numerous brain diseases. Despite recent advances in stem cell tec
Externí odkaz:
https://doaj.org/article/67087aa005524785a94160049b72e495
Autor:
Aubin Michalon, Andreas Hagenbuch, Christian Huy, Evita Varela, Benoit Combaluzier, Thibaud Damy, Ole B. Suhr, Maria J. Saraiva, Christoph Hock, Roger M. Nitsch, Jan Grimm
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Analyzing memory B cell repertoires of the healthy elderly enabled Michalon et al. to develop a recombinant human antibody selective for transthyretin amyloid. This antibody removes cardiac amyloid through recruitment of phagocytic immune cells.
Externí odkaz:
https://doaj.org/article/0bd15e092d1f47498ea907338e89a448
Autor:
Ruiqing Ni, Roger M. Nitsch
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
An early detection and intervention for dementia represent tremendous unmet clinical needs and priorities in society. A shared feature of neurodegenerative diseases causing dementia is the abnormal accumulation and spreading of pathological protein a
Externí odkaz:
https://doaj.org/article/a19509ed40ae45a68ef0728127113892
Autor:
Tunahan Kirabali, Serena Rigotti, Alessandro Siccoli, Filip Liebsch, Adeola Shobo, Christoph Hock, Roger M. Nitsch, Gerhard Multhaup, Luka Kulic
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract An impairment of amyloid β-peptide (Aβ) clearance is suggested to play a key role in the pathogenesis of sporadic Alzheimer’s disease (AD). Amyloid degradation is mediated by various mechanisms including fragmentation by enzymes like nep
Externí odkaz:
https://doaj.org/article/47910761693948dea8c5d3ea5f4deee8
Autor:
Andreas Weihofen, YuTing Liu, Joseph W. Arndt, Christian Huy, Chao Quan, Benjamin A. Smith, Jean-Luc Baeriswyl, Nicole Cavegn, Luzia Senn, Lihe Su, Galina Marsh, Pavan K. Auluck, Fabio Montrasio, Roger M. Nitsch, Warren D. Hirst, Jesse M. Cedarbaum, R. Blake Pepinsky, Jan Grimm, Paul H. Weinreb
Publikováno v:
Neurobiology of Disease, Vol 124, Iss , Pp 276-288 (2019)
Aggregation of α-synuclein (α-syn) is neuropathologically and genetically linked to Parkinson's disease (PD). Since stereotypic cell-to-cell spreading of α-syn pathology is believed to contribute to disease progression, immunotherapy with antibodi
Externí odkaz:
https://doaj.org/article/9c312d730f4444538aa0bb5f11e8cda5