Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Roger Leger"'
Autor:
David Dodds, Jeffrey L. Bose, Ming-De Deng, Gilles R. Dubé, Trudy H. Grossman, Alaina Kaiser, Kashmira Kulkarni, Roger Leger, Sara Mootien-Boyd, Azim Munivar, Julia Oh, Matthew Pestrak, Komal Rajpura, Alexander P. Tikhonov, Traci Turecek, Travis Whitfill
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Using live microbes as therapeutic candidates is a strategy that has gained traction across multiple therapeutic areas. In the skin, commensal microorganisms play a crucial role in maintaining skin barrier function, homeostasis, and cutaneou
Externí odkaz:
https://doaj.org/article/ba1d4abd99a34cf9a5fdc6d24226e084
Autor:
Jeffrey L. Bose, Sara Mootien-Boyd, Alaina Kaiser, Matthew Pestrak, Ming-De Dong, Roger Leger, Trudy H. Grossman, Traci Turecek, Travis Whitfill, Azim Munivar, Gilles R. Dubé, Kashmira Kulkarni, Julia Oh, Alexander P. Tikhonov, Komal Rajpura, David R. Dodds
Publikováno v:
mSphere
mSphere, Vol 5, Iss 3 (2020)
mSphere, Vol 5, Iss 3, p e00360-20 (2020)
mSphere, Vol 5, Iss 3 (2020)
mSphere, Vol 5, Iss 3, p e00360-20 (2020)
The skin microbiome is rich in opportunities for novel therapeutics for skin diseases, and synthetic biology offers the advantage of providing novel functionality or therapeutic benefit to live biotherapeutic products. The development of novel bacter
Autor:
Véronique Paradis, Martin Robitaille, Pieter van Wyk, Dominique P. Bridon, Karen Thibaudeau, Omar Quraishi, Jean-Paul Castaigne, Roger Leger, Xicai Huang, Chantal Soucy, Nathalie Bousquet-Gagnon
Publikováno v:
Bioconjugate Chemistry. 16:1000-1008
A series of human insulin maleimido derivatives with short and long linkers was synthesized by exploiting the variations in the pK(a) values and environment of the three amino groups present in the protein. The syntheses were accomplished in organic
Autor:
Corinne Benquet, Roger Leger, Dominique P. Bridon, Xicai Huang, Pieter van Wyk, Omar Quraishi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:841-845
Three peptide fragments of the kringle 5 region of plasminogen and their respective N- and C-terminus maleimido derivatives conjugated to Cys34 of human serum albumin were evaluated in vitro using a human umbilical vein endothelial cell (HUVEC) migra
Autor:
Yakira Landaverry, Nicole Williams, Suzanne Chamberland, Thomas E. Renau, Vrushali Tembe, Deidre Madsen, Roger Leger, Rose Yen, Keith Huie, Michael N. Dudley, Jason Z. Zhang, David A. Griffith, Renee Litman, William J. Watkins
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4241-4244
Following the optimization of diamine-containing efflux pump inhibitors with respect to in vitro potentiation activity, in vivo stability and acute toxicity, we addressed the question of how to control the pharmacokinetic properties of the series. Up
Autor:
Yoshida Kenichi, Shigeru Hosono, William J. Watkins, Haruko Kawato, Yoshihiro Yokomizo, Kiyoshi Nakayama, Kumi Yoshida, Toshiharu Ohta, Kazuki Hoshino, Roger Leger, Masami Ohtsuka, Ving J. Lee, Jason Z. Zhang, Yohei Ishida, Thomas E. Renau, Hiroko Ishida
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:4201-4204
The identification of a series of compounds that specifically inhibit efflux by the MexAB-OprM pump system in Pseudomonas aeruginosa is described. Synthesis and in vitro structure-activity relationships (SARs) are outlined. Early leads lacked activit
Autor:
Pieter van Wyk, Jean-Paul Castaigne, Roger Leger, Omar Quraishi, Martin Robitaille, Corinne Benquet, Julie Carette, Elizabeth Denholm, Dominique P. Bridon, Nathalie Bousquet-Gagnon, Isabelle Pellerin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3571-3575
Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, recept
Autor:
Hiroko Ishida, Will Watkins, Ving J. Lee, Richard Fronko, May Lee, Tom Renau, Jorge Galazzo, Mark S. Warren, Roger Leger, Olga Lomovskaya, Kazuki Hoshino, Suzanne Chamberland, Deidre Cho, Scott J. Hecker, Angela Lee, Johanne Blais
Publikováno v:
Antimicrobial Agents and Chemotherapy. 45:105-116
Whole-cell assays were implemented to search for efflux pump inhibitors (EPIs) of the three multidrug resistance efflux pumps (MexAB-OprM, MexCD-OprJ, MexEF-OprN) that contribute to fluoroquinolone resistance in clinical isolates of Pseudomonas aerug
Autor:
Roger Leger, Olga Lomovskaya, Miles She, Rose Yen, Eric M. Flamme, Suzanne Chamberland, Joan Sangalang, Carla L. Gannon, Thomas E. Renau, Ving J. Lee
Publikováno v:
ChemInform. 33
Several classes of peptidomimetics of the efflux pump inhibitor D-ornithine-D-homophenylalanine-3-aminoquinoline (MC-02,595) have been prepared and evaluated for their ability to potentiate the activity of the fluoroquinolone levofloxacin in Pseudomo
Publikováno v:
Carbohydrate Research. 228:145-155
Application of the Keck C -allylation of organic halides to 2-bromo-2-deoxy- d -arabinolactone resulted in the formation of mixtures of 2- C -allyl lactones. The stereochemical preferences observed were dictated by the nature of vicinal and remotely