Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Roger L. Nation"'
Autor:
Kade D. Roberts, Yan Zhu, Mohammad A. K. Azad, Mei-Ling Han, Jiping Wang, Lynn Wang, Heidi H. Yu, Andrew S. Horne, Jo-Anne Pinson, David Rudd, Nicolas H. Voelcker, Nitin A. Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J. Hecker, Philip E. Thompson, Roger L. Nation, Michael N. Dudley, David C. Griffith, Tony Velkov, Jian Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Polymyxins are often the last therapeutic option for multidrug-resistant (MDR) bacteria, but have suboptimal safety and efficacy. Here the authors report the discovery and development of a synthetic lipopeptide with an improved safety and efficacy ag
Externí odkaz:
https://doaj.org/article/0e3e6c3ab9774848b67a0f077533e996
Autor:
Patrick O. Hanafin, Roger L. Nation, Marc H. Scheetz, Alexandre P. Zavascki, Ana M. Sandri, Andrea L. Kwa, Benjamin P. Z. Cherng, Christine J. Kubin, Michael T. Yin, Jiping Wang, Jian Li, Keith S. Kaye, Gauri G. Rao
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 12, Pp 1525-1537 (2021)
Abstract Polymyxin B (PMB) has reemerged as a last‐line therapy for infections caused by multidrug‐resistant gram‐negative pathogens, but dosing is challenging because of its narrow therapeutic window and pharmacokinetic (PK) variability. Popul
Externí odkaz:
https://doaj.org/article/90ef046582c94502abeab347f50b51a1
Autor:
Jessica R. Tait, Hajira Bilal, Tae Hwan Kim, Abigail Oh, Anton Y. Peleg, John D. Boyce, Antonio Oliver, Phillip J. Bergen, Roger L. Nation, Cornelia B. Landersdorfer
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 26, Iss , Pp 55-63 (2021)
ABSTRACT: Objectives: Hypermutable Pseudomonas aeruginosa strains are a major challenge in cystic fibrosis. We investigated bacterial killing and resistance emergence for approved ceftazidime and tobramycin regimens, alone and in combination. Methods
Externí odkaz:
https://doaj.org/article/688e02d5fd9f4402b936069261b1b994
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Within a few years after the first successful clinical use of penicillin, investigations were conducted in animal infection models to explore a range of factors that were considered likely to influence the antibacterial response to the drug. Those st
Externí odkaz:
https://doaj.org/article/03ac342ee4e246c3954b8a7d396a88b6
Autor:
Agnes Loo Yee Cheah, Allen C. Cheng, Denis Spelman, Roger L. Nation, David C. M. Kong, Emma S. McBryde
Publikováno v:
BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Clinical studies and mathematical simulation suggest that active surveillance with contact isolation is associated with reduced vancomycin-resistant enterococci (VRE) prevalence compared to passive surveillance. Models using pre-
Externí odkaz:
https://doaj.org/article/733f784de29e40fc812cfdb203d1cc2d
Autor:
Jessica R. Tait, Hajira Bilal, Kate E. Rogers, Yinzhi Lang, Tae-Hwan Kim, Jieqiang Zhou, Steven C. Wallis, Jürgen B. Bulitta, Carl M. J. Kirkpatrick, David L. Paterson, Jeffrey Lipman, Phillip J. Bergen, Jason A. Roberts, Roger L. Nation, Cornelia B. Landersdorfer
Publikováno v:
Antibiotics, Vol 11, Iss 1, p 101 (2022)
We evaluated piperacillin-tazobactam and tobramycin regimens against Pseudomonas aeruginosa isolates from critically ill patients. Static-concentration time-kill studies (SCTK) assessed piperacillin-tazobactam and tobramycin monotherapies and combina
Externí odkaz:
https://doaj.org/article/2c239a05246f49388e27fd8db173a442
Autor:
Vanessa E. Rees, Jürgen B. Bulitta, Antonio Oliver, Roger L. Nation, Cornelia B. Landersdorfer
Publikováno v:
Pharmaceutics, Vol 11, Iss 9, p 470 (2019)
Hypermutable Pseudomonas aeruginosa strains have a greatly increased mutation rate and are prevalent in chronic respiratory infections. Initially, we systematically evaluated the time-course of total and resistant populations of hypermutable (PAO∆m
Externí odkaz:
https://doaj.org/article/e80409e6f8fd44ce8c699e2d79aca13f
Autor:
Zackery P. Bulman, Liang Chen, Thomas J. Walsh, Michael J. Satlin, Yuli Qian, Jürgen B. Bulitta, Charles A. Peloquin, Patricia N. Holden, Roger L. Nation, Jian Li, Barry N. Kreiswirth, Brian T. Tsuji
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The rapid increase of carbapenem resistance in Gram-negative bacteria has resurrected the importance of the polymyxin antibiotics. The recent discovery of plasmid-mediated polymyxin resistance (mcr-1) in carbapenem-resistant Enterobacteriace
Externí odkaz:
https://doaj.org/article/109d08cddec34fa99f3d35936c35c8dc
Publikováno v:
Antibiotics, Vol 8, Iss 1, p 24 (2019)
Polymyxins are valuable antimicrobials for the management of multidrug-resistant Gram-negative bacteria; however, nephrotoxicity associated with these drugs is a very common side effect that occurs during treatment. This article briefly reviews nephr
Externí odkaz:
https://doaj.org/article/86f0591494c840a39741e74ada6dab59
Autor:
Jinxin Zhao, Soon-Ee Cheah, Kade D. Roberts, Roger L. Nation, Philip E. Thompson, Tony Velkov, Zongjun Du, Matthew D. Johnson, Jian Li
Publikováno v:
mSphere, Vol 1, Iss 4 (2016)
ABSTRACT Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line therapy. In this study, we investigated the antimicrobial activity of a novel polymyxin, FADDI-019, against Staph
Externí odkaz:
https://doaj.org/article/bd826626e4e648538e291caaefb4a34a