Zobrazeno 1 - 10
of 470
pro vyhledávání: '"Roger L Williams"'
Autor:
Maren Heimhalt, Alex Berndt, Jane Wagstaff, Madhanagopal Anandapadamanaban, Olga Perisic, Sarah Maslen, Stephen McLaughlin, Conny Wing-Heng Yu, Glenn R Masson, Andreas Boland, Xiaodan Ni, Keitaro Yamashita, Garib N Murshudov, Mark Skehel, Stefan M Freund, Roger L Williams
Publikováno v:
eLife, Vol 10 (2021)
The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is associated with some cancers, we reconstituted mTORC1 with DEPTOR to understand its function. We find t
Externí odkaz:
https://doaj.org/article/f3e3156092d447fd9fa28ea08dad4816
Autor:
Yohei Ohashi, Shirley Tremel, Glenn Robert Masson, Lauren McGinney, Jerome Boulanger, Ksenia Rostislavleva, Christopher M Johnson, Izabella Niewczas, Jonathan Clark, Roger L Williams
Publikováno v:
eLife, Vol 9 (2020)
The lipid kinase VPS34 orchestrates diverse processes, including autophagy, endocytic sorting, phagocytosis, anabolic responses and cell division. VPS34 forms various complexes that help adapt it to specific pathways, with complexes I and II being th
Externí odkaz:
https://doaj.org/article/7d8937877eeb407298a9c962587ff946
Autor:
Heather P Harding, Adriana Ordonez, Felicity Allen, Leopold Parts, Alison J Inglis, Roger L Williams, David Ron
Publikováno v:
eLife, Vol 8 (2019)
The eukaryotic translation initiation factor 2α (eIF2α) kinase GCN2 is activated by amino acid starvation to elicit a rectifying physiological program known as the Integrated Stress Response (ISR). A role for uncharged tRNAs as activating ligands o
Externí odkaz:
https://doaj.org/article/a51ed5f0188c4cd88251aec3835f683c
Autor:
Romy Walser, John E Burke, Elena Gogvadze, Thomas Bohnacker, Xuxiao Zhang, Daniel Hess, Peter Küenzi, Michael Leitges, Emilio Hirsch, Roger L Williams, Muriel Laffargue, Matthias P Wymann
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001587 (2013)
All class I phosphoinositide 3-kinases (PI3Ks) associate tightly with regulatory subunits through interactions that have been thought to be constitutive. PI3Kγ is key to the regulation of immune cell responses activated by G protein-coupled receptor
Externí odkaz:
https://doaj.org/article/70630b19e2284767a532785dcfa64b7a
Autor:
Manoj K. Rathinaswamy, Meredith L. Jenkins, Benjamin R. Duewell, Xuxiao Zhang, Noah J. Harris, John T. Evans, Jordan T.B. Stariha, Udit Dalwadi, Kaelin D. Fleming, Harish Ranga-Prasad, Calvin K. Yip, Roger L. Williams, Scott D. Hansen, John E. Burke
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112172- (2023)
Summary: Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells and can form two distinct complexes (p110γ-p84 and p110γ-p101), which are differentially activated by G protein-coupled receptors (GPCRs) and Ras. Using a combination
Externí odkaz:
https://doaj.org/article/adaec01d7c824f20bc3e5572c80805c4
Autor:
Grace Q. Gong, Benoit Bilanges, Ben Allsop, Glenn R. Masson, Victoria Roberton, Trevor Askwith, Sally Oxenford, Ralitsa R. Madsen, Sarah E. Conduit, Dom Bellini, Martina Fitzek, Matt Collier, Osman Najam, Zhenhe He, Ben Wahab, Stephen H. McLaughlin, A. W. Edith Chan, Isabella Feierberg, Andrew Madin, Daniele Morelli, Amandeep Bhamra, Vanesa Vinciauskaite, Karen E. Anderson, Silvia Surinova, Nikos Pinotsis, Elena Lopez-Guadamillas, Matthew Wilcox, Alice Hooper, Chandni Patel, Maria A. Whitehead, Tom D. Bunney, Len R. Stephens, Phillip T. Hawkins, Matilda Katan, Derek M. Yellon, Sean M. Davidson, David M. Smith, James B. Phillips, Richard Angell, Roger L. Williams, Bart Vanhaesebroeck
Publikováno v:
Nature. 618:159-168
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 2, Pp 229-241 (2019)
VPS34 phosphorylates phosphatidylinositol to produce PtdIns3P and is the progenitor of the phosphoinositide 3-kinase (PI3K) family. VPS34 has a simpler domain organization than class I PI3Ks, which belies the complexity of its quaternary organization
Externí odkaz:
https://doaj.org/article/48fbe0ce81f941fb90b0a269938ec657
Autor:
Wen-Ting Lo, Hassane Belabed, Murat Kücükdisli, Juliane Metag, Yvette Roske, Polina Prokofeva, Yohei Ohashi, André Horatscheck, Davide Cirillo, Michael Krauss, Christopher Schmied, Martin Neuenschwander, Jens Peter von Kries, Guillaume Médard, Bernhard Kuster, Olga Perisic, Roger L. Williams, Oliver Daumke, Bernard Payrastre, Sonia Severin, Marc Nazaré, Volker Haucke
Phosphatidylinositol 3-kinase type 2α (PI3KC2α) and related class II PI3K isoforms are of increasing biomedical interest because of their crucial roles in endocytic membrane dynamics, cell division and signaling, angiogenesis, and platelet morpholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7e2f007efebfff9a9b182e223cbec7b
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
http://edoc.mdc-berlin.de/22106/7/22106suppl.zip
Autor:
Manoj K Rathinaswamy, Meredith L Jenkins, Xuxiao Zhang, Jordan TB Stariha, Harish Ranga-Prasad, Udit Dalwadi, Kaelin D. Fleming, Calvin K Yip, Roger L Williams, John E Burke
Class IB phosphoinositide 3-kinase (PI3Kγ) is activated in immune cells by diverse stimuli and can form two distinct complexes, with the p110γ catalytic subunit binding to either p101 or p84 regulatory subunits. These two complexes are differential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7de2ee64dffcb8ade04f312779359b32
https://doi.org/10.1101/2022.07.29.502076
https://doi.org/10.1101/2022.07.29.502076
Publikováno v:
Autophagy. 17:823-825
Phosphatidylinositol-3-phosphate (PtdIns3P) is essential for generating autophagosomes and regulating endocytic trafficking. Recently, we have shown that the activities of human PIK3C3/VPS34-containing complexes I and II, which synthesize PtdIns3P, a