Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Roger L Chang"'
Autor:
Ali Ebrahim, Eivind Almaas, Eugen Bauer, Aarash Bordbar, Anthony P Burgard, Roger L Chang, Andreas Dräger, Iman Famili, Adam M Feist, Ronan MT Fleming, Stephen S Fong, Vassily Hatzimanikatis, Markus J Herrgård, Allen Holder, Michael Hucka, Daniel Hyduke, Neema Jamshidi, Sang Yup Lee, Nicolas Le Novère, Joshua A Lerman, Nathan E Lewis, Ding Ma, Radhakrishnan Mahadevan, Costas Maranas, Harish Nagarajan, Ali Navid, Jens Nielsen, Lars K Nielsen, Juan Nogales, Alberto Noronha, Csaba Pal, Bernhard O Palsson, Jason A Papin, Kiran R Patil, Nathan D Price, Jennifer L Reed, Michael Saunders, Ryan S Senger, Nikolaus Sonnenschein, Yuekai Sun, Ines Thiele
Publikováno v:
Molecular Systems Biology, Vol 11, Iss 10, Pp n/a-n/a (2015)
Externí odkaz:
https://doaj.org/article/889764d4207842bb8d486cb49f32b9c4
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
Growth is a fundamental process of life. Growth requirements are well‐characterized experimentally for many microbes; however, we lack a unified model for cellular growth. Such a model must be predictive of events at the molecular scale and capable
Externí odkaz:
https://doaj.org/article/d2339f0bc6e74f0e9897c0a874ad4033
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 9, p e1000938 (2010)
Recent advances in structural bioinformatics have enabled the prediction of protein-drug off-targets based on their ligand binding sites. Concurrent developments in systems biology allow for prediction of the functional effects of system perturbation
Externí odkaz:
https://doaj.org/article/411025646d134aacb96038b54f586b96
Autor:
Mike T. Veling, Dan T. Nguyen, Nicole N. Thadani, Michela E. Oster, Nathan J. Rollins, Kelly P. Brock, Neville P. Bethel, Samuel Lim, David Baker, Jeffrey C. Way, Debora S. Marks, Roger L. Chang, Pamela A. Silver
Publikováno v:
ACS Synth Biol
Many organisms can survive extreme conditions and successfully recover to normal life. This extremotolerant behavior has been attributed in part to repetitive, amphipathic, and intrinsically disordered proteins that are upregulated in the protected s
Autor:
Tai L. Ng, Erika J. Olson, Tae Yeon Yoo, H. Sloane Weiss, Yukiye Koide, Peter D. Koch, Nathan J. Rollins, Pia Mach, Tobias Meisinger, Trenton Bricken, Timothy Z. Chang, Colin Molloy, Jérôme Zürcher, Roger L. Chang, Timothy J. Mitchison, John I. Glass, Debora S. Marks, Jeffrey C. Way, Pamela A. Silver
Publikováno v:
mSystems. 7(2)
Suppression of the host innate immune response is a critical aspect of viral replication. Upon infection, viruses may introduce one or more proteins that inhibit key immune pathways, such as the type I interferon pathway. However, the ability to pred
Autor:
Pamela A. Silver, Thadani Nn, Roger L. Chang, David Baker, Mike T. Veling, Jeffrey C. Way, Bethel Np, Oster Me, Nguyen Dt, Nathanael J. Rollins, Kelly P Brock, Debora S. Marks
Many organisms can survive extreme conditions and successfully recover to normal life. This extremotolerant behavior has been attributed in part to repetitive, amphipathic, and intrinsically disordered proteins that are upregulated in the protected s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17a46f0161144e3d2f717b097c45156b
https://doi.org/10.1101/2021.10.01.462432
https://doi.org/10.1101/2021.10.01.462432
Autor:
Shengyu Yang, Iosim S, Roger L. Chang, Christopher E. Mason, Cem Meydan, Kirill Grigorev, Najjar D, Christopher R. Chin, Mike T. Veling, Rahmatulloev S, Pamela A. Silver, Moszary C, Ebrahim Afshinnekoo, Restrepo U, Craig Westover, Colon R, Daniel Butler
SummarySpaceflight has been documented to produce detrimental effects to physiology and genomic stability, partly a result of Galactic Cosmic Radiation (GCR). In recent years, extensive research into extremotolerant organisms has begun to reveal how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afe6f66d37ac95a6c8efe34e371c664a
https://doi.org/10.1101/2020.11.10.373571
https://doi.org/10.1101/2020.11.10.373571
Autor:
Matthew C. Robinson, Yujia Alina Chan, Ruddy Wattiez, Sabine Matallana-Surget, Roger L. Chang, Joel W Sher, Adam Godzik, Julian A Stanley, Ashton R. Omdahl, Zhanwen Li
Oxidative stress alters cell viability, from microorganism irradiation sensitivity to human aging and neurodegeneration. Deleterious effects of protein carbonylation by reactive oxygen species (ROS) make understanding molecular properties determining
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7a20145a0473868815377171f89cae
Autor:
Joseph Koussa, Bushra Saeed Dohai, Hong Cai, Roger L. Chang, Amphun Chaiboonchoe, David R. Nelson, Lila Ghamsari, Patrick Ng, Haiyuan Yu, Jason A. Papin, Ashish Jaiswal, Kenan Jijakli, Basel Khraiwesh, S. Balaji, Xinping Yang, Kourosh Salehi-Ashtiani
Publikováno v:
Molecular BioSystems. 12:2394-2407
Metabolic networks, which are mathematical representations of organismal metabolism, are reconstructed to provide computational platforms to guide metabolic engineering experiments and explore fundamental questions on metabolism. Systems level analys
Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow
Autor:
Nathan E. Lewis, Bernhard O. Palsson, George M. Church, Evan Buckmiller, Jing Xia, Chen Yang, James T. Yurkovich, Donghyuk Kim, Hooman Hefzi, Roger L. Chang, Harris H. Wang, Elizabeth Brunk, Byung-Kwan Cho
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 43
Brunk, E, Chang, R L, Xia, J, Hefzi, H, Yurkovich, J T, Kim, D, Buckmiller, E, Wang, H H, Cho, B-K, Yang, C, Palsson, B O, Church, G M & Lewis, N E 2018, ' Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 43, pp. 11096-11101 . https://doi.org/10.1073/pnas.1811971115
Brunk, E, Chang, R L, Xia, J, Hefzi, H, Yurkovich, J T, Kim, D, Buckmiller, E, Wang, H H, Cho, B-K, Yang, C, Palsson, B O, Church, G M & Lewis, N E 2018, ' Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 43, pp. 11096-11101 . https://doi.org/10.1073/pnas.1811971115
Understanding the complex interactions of protein posttranslational modifications (PTMs) represents a major challenge in metabolic engineering, synthetic biology, and the biomedical sciences. Here, we present a workflow that integrates multiplex auto