Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Roger L, Papke"'
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106736- (2023)
We discuss models for the activation and desensitization of α7 nicotinic acetylcholine receptors (nAChRs) and the effects of efficacious type II positive allosteric modulators (PAMs) that destabilize α7 desensitized states. Type II PAMs such as PNU
Externí odkaz:
https://doaj.org/article/ff84c7fc09c649549e6b17ec2d68b6df
Autor:
Katrin Richter, Roger L. Papke, Clare Stokes, Danika C. Roy, Eduardo S. Espinosa, Philipp M. K. Wolf, Andreas Hecker, Juliane Liese, Vijay K. Singh, Winfried Padberg, Klaus-Dieter Schlüter, Marius Rohde, J. Michael McIntosh, Barbara J. Morley, Nicole A. Horenstein, Veronika Grau, Alain R. Simard
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Activation of nicotinic acetylcholine receptors (nAChRs) expressed by innate immune cells can attenuate pro-inflammatory responses. Silent nAChR agonists, which down-modulate inflammation but have little or no ionotropic activity, are of outstanding
Externí odkaz:
https://doaj.org/article/1f0c695d5b094b88ab15c35a1caca9c0
Autor:
Roger L. Papke, Clare Stokes
Publikováno v:
Molecular Pharmacology. 103:63-76
The development of highly efficacious positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChR) has proven useful in defining the ligand dependence of the conformational dynamics of α7 receptors. No such effective modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10f7a529354c93e03d5d7af95bc4fbd
https://doi.org/10.1124/molpharm.122.000591
https://doi.org/10.1124/molpharm.122.000591
Autor:
Clare Stokes, Gisela Andrea Camacho-Hernandez, Ganesh A. Thakur, Xiaoxuan Wu, Palmer Taylor, Roger L. Papke
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:157-171
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a706249227ce59ef8def5b10404d631a
https://doi.org/10.1124/jpet.122.001354
https://doi.org/10.1124/jpet.122.001354
Publikováno v:
Molecules, Vol 26, Iss 18, p 5643 (2021)
The α7 nicotinic acetylcholine receptor (nAChR) is an important target given its role in cognitive function as well as in the cholinergic anti-inflammatory pathway, where ligands that are effective at stabilizing desensitized states of the receptor
Externí odkaz:
https://doaj.org/article/840b1cbdcc7540c3a3df8e05a6ffb8ca
Autor:
Alican Gulsevin, Roger L. Papke, Clare Stokes, Hue N. T. Tran, Aihua H. Jin, Irina Vetter, Jens Meiler
Publikováno v:
Toxins, Vol 13, Iss 8, p 555 (2021)
α-conotoxins are 13–19 amino acid toxin peptides that bind various nicotinic acetylcholine receptor (nAChR) subtypes. α-conotoxin Mr1.7c (MrIC) is a 17 amino acid peptide that targets α7 nAChR. Although MrIC has no activating effect on α7 nAChR
Externí odkaz:
https://doaj.org/article/59b9fd8bde3d41f1acc5a78ea6fe96a6
Autor:
Clare Stokes, Jose A. Pino, D. Walker Hagan, Gonzalo E. Torres, Edward A. Phelps, Nicole A. Horenstein, Roger L. Papke
Publikováno v:
Addiction Biology. 27
The use of areca nuts (areca) in the form of betel quids constitutes the fourth most common addiction in the world, associated with high risk for oral disease and cancer. Areca is a complex natural product, making it difficult to identify specific co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f337902be44ca6e0a3459615a38e4dd1
https://doi.org/10.1111/adb.13223
https://doi.org/10.1111/adb.13223
Publikováno v:
eLS. :946-957
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba2a06af96819a1e553a68aa1a8c11b3
https://doi.org/10.1002/9780470015902.a0029237
https://doi.org/10.1002/9780470015902.a0029237
Autor:
Douglas R. Miller, Roger L. Papke, Sumanta Garai, Lucas Cantwell, Ganesh A. Thakur, Clare Stokes, Habibeh Khoshbouei
Publikováno v:
Mol Pharmacol
The currents of α7 nicotinic acetylcholine receptors activated by acetylcholine (ACh) are brief. The channel has high permeability to calcium relative to monovalent cations and shows inward rectification. It has been previously noted that in the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409573b825d875e596306d5174d676dc
https://doi.org/10.1124/molpharm.120.000012
https://doi.org/10.1124/molpharm.120.000012
Autor:
Sumanta Garai, Roger L. Papke, Clare Stokes, Khalil A. Abboud, Nicole A. Horenstein, Arthur D. Zimmerman, Ganesh A. Thakur
Publikováno v:
Molecular Pharmacology. 98:292-302
Many synthetic compounds to which we attribute specific activities are produced as racemic mixtures of stereoisomers, and it may be that all the desired activity comes from a single enantiomer. We have previously shown this to be the case with the α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::917339f3dcf82aad421d14745ea756ad
https://doi.org/10.1124/mol.120.119958
https://doi.org/10.1124/mol.120.119958